Xylazine Hydrochloride Property

Melting point:

150-164?C (dec.)

storage temp. 

2-8°C

solubility 

≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O

form 

Solid

color 

White to Almost white

Water Solubility 

Soluble in water

Merck 

14,10080

BRN 

6448471

InChI

InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H

InChIKey

QYEFBJRXKKSABU-UHFFFAOYSA-N

SMILES

N(C1SCCCN=1)C1C(=CC=CC=1C)C.Cl

CAS DataBase Reference

23076-35-9(CAS DataBase Reference)

Safety

Hazard Codes 

T

Risk Statements 

25-36/37/38

Safety Statements 

26-36/37/39-45

RIDADR 

2811

WGK Germany 

-

RTECS 

XJ0776350

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29349990

Toxicity

dog,LD50,intramuscular,47mg/kg (47mg/kg),Clinical Toxicology. Vol. 15, Pg. 281, 1979.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Xylazine Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Xylazine Hydrochloride is an alpha-2 agonist with sedative, analgesic, and muscle relaxant properties. It is approved for use in dogs,cats,horses,deer,and elk. This agent causes vomiting in a large percentage of cats and in some dogs. Xylazine is antagonized by yohimbine. It produces effective analgesia in horses and is often used for treating the pain associated with colic and for sedation for minor procedures.It is also used in combination with ketamine for short-term feld procedures in horses,such as castration and suturing of extensive wounds，because this combination usually produces 15 to 20 minutes of recumbency. Extralabel use of xylazine for cesarean sections in cattle and other surgical procedures is common. Xylazine Hydrochloride is used in cats and dogs as a tranquilizer and in combination with other injectable agents for surgical procedures.

Definition

ChEBI: Xylazine hydrochloride is the hydrochloride salt of xylazine. It is used as a sedative, analgesic, and muscle relaxant in veterinary medicine. It has a role as an alpha-adrenergic agonist, an analgesic, an emetic, a muscle relaxant and a sedative. It contains a xylazine(1+).

brand name

Rompun (Bayer Animal Health).

Biological Activity

Xylazine Hydrochloride is a strong agonist of α2-adrenoceptor [1].xylazine hcl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mm) [2]. in the analgesic testing, xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. in addition, xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the ic50 value of 18nm. furthermore, xylazine has displayed a potent specific [3h]-dihydromorphine binding inhibition with the ic50 value of 8μm in opiate receptor binding test [1].

Biochem/physiol Actions

Xylazine is used as a sedative in goats as it is safe, active and a cheap drug. It is a centrally acting drug, which exhibits muscle relaxant and analgesic properties.

Side effects

Respiratory depression, low blood pressure, slowed heart rate, hypothermia, pupil constriction and, sometimes, high blood sugar levels.
The pupil constriction and respiratory depression are particularly of concern, as these are very common and widely understood effects of an opioid overdose.
Severe, necrotic skin ulcerations are the most striking side effect of xylazine. Notably, while these skin ulcerations may appear at the site of injection, they may appear at a completely different site on the body altogether. Soft tissue infections are often associated with IV drug use of more conventional illicit substances such as opioids, but these are almost always located at the injection site.

Veterinary Drugs and Treatments

Xylazine Hydrochloride is approved for use in dogs, cats, horses, deer, and elk. It is indicated in dogs, cats, and horses to produce a state of sedation with a shorter period of analgesia, and as a preanesthetic before local or general anesthesia. Because of the emetic action of xylazine in cats, it is occasionally used to induce vomiting after ingesting toxins.

References

[1] s. browning, d.lawrence1, a.livingston & b.morris. interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] colić m1, cupić v, pavicić l, vucević d, varagić vm. xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. methods find exp clin pharmacol. 2000 sep;22(7):557-62.