Lumacaftor (VX-809)

Product Name: Lumacaftor (VX-809)
CAS No.: 936727-05-8
Chemical Name: Lumacaftor (VX-809)
Synonyms: Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;Rumakato;VRT 826809;3-(6-{[1-(2;VX809;VX-809
CBNumber: CB32489655
Molecular Formula: C24H18F2N2O5
Formula Weight: 452.41
MOL File: 936727-05-8.mol

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Lumacaftor (VX-809) Property

Melting point:: 200-205oC
Boiling point:: 653.0±55.0 °C(Predicted)
Density: 1.51
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.95±0.10(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
InChIKey: UFSKUSARDNFIRC-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C5OC(F)(F)OC5=C4)CC3)=O)=CC=C2C)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

TRC

Product number: V900700
Product name: VX809
Packaging: 10mg
Price: $85
Updated: 2021/12/16

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Lumacaftor (VX-809) Chemical Properties,Usage,Production

Uses

VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.

Biological Activity

vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several

target

CFTR

Mode of action

CF is a hereditary condition caused by mutations in the CFTR gene, which provides instructions for producing an ion channel protein called CF transmembrane conductance regulator (CFTR). These mutations cause defects in the CFTR protein, which disrupts the normal salt-water transport across the cell membrane and produces thick, sticky mucus that may accumulate in different organs, including the lungs. One of the common mutations in the CFTR gene is the so-called F508del mutation, which results in a defective misfolded CFTR protein. The misfolded protein is degraded by the cell before it can reach the cell membrane. Even if some of the defective proteins reach the cell membrane, they are unable to open correctly and allow the passage of chloride ions. Lumacaftor and ivacaftor work together to restore the function of the CFTR protein at the cell membrane. Lumacaftor increases the stability of defective CFTR proteins, helping them reach the cell membrane and stay there longer. But because it does not address the problem with the opening of the channel, lumacaftor is generally used in combination with ivacaftor, which acts on the defective proteins, helping them to open more often so that the salt-water balance across the cell surface is restored.

Lumacaftor (VX-809) Preparation Products And Raw materials

Raw materials

Preparation Products

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Lumacaftor (VX-809) Suppliers

China 219 India 6 United States 16 Global 241

ShangHai Onsyn-Chemical Technology Co., Ltd.

Tel: 021-58359326 13124831025
Fax: +86-21-58359326
Email: angsihuaxue@126.com
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Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd

Tel: +86-0311-67591193 +86-15030197620
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Email: sales02@dingminpharma.com
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China Shenyang Tyschem CO. ,LTD

Tel: +86-024-83607930; 18640359690
Fax: 024-83607930
Email: sales@honghuchem.com
Country: China
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Shanghai Boyle Chemical Co., Ltd.

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Email: sales@boylechem.com
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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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Email: sales@BioChemBest.com
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Shanghai Scientia Pharmaceutical Technology Co., Ltd.

Tel: 21-21-54301573 13917723525
Fax: (86)21-51861981
Email: sales@scientiapharm.com
Country: China
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
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China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
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Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
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View Lastest Price from Lumacaftor (VX-809) manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $0.00/g/Bag
Min. Order: 1g
Purity: 98.0%~102.0%
Supply Ability: 10kg/month
Release date: 2021-06-03

Hebei Weibang Biotechnology Co., Ltd

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-27

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lumacaftor 936727-05-8
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-12

936727-05-8, Lumacaftor (VX-809)Related Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 1H-Pyrrole-2-carboxaMide, 4-[2-[(2-chloro-4-fluorophenyl)aMino]-5-Methyl-4-pyriMidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]- VX 702 Bortezomib Y27632 (hydrochloride) Dasatinib VX-770 VX-661 Ibrutinib

3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid

VX-809

3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid

Lumacaftor

3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid

VRT 826809

CS-719

Lumacaftor(vx-809,vx809)

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)be

VX 809, >=98%

VX-809 (LUMACAFTOR);VX 809

3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl

VX-809 + IVACAFTOR

VX-809 (LuMacaftor)

3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor

VX809;VX-809

3-(6-{[1-(2

Lumacaftor VX809

VX-809, Lumacaftor, VRT 826809

Benzoic acid, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]-

3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropaneca...

3-{6-[1-(2,2-difluoro-1,3-dioxaindan-5-yl)cycloprop aneamido]-3-methylpyridin-2-yl}benzoic acid

3-(6-(1-(2,2-Difluorobenzod1,3dioxol-5-yl)cyclopropane-carboxcarboxamido)-3-methylpyridin-2-yl)-benzoic acid

Lumacaftor in methanol

Rumakato

936727-05-8

Inhibitors

VX-809