Lumacaftor (VX-809)

Product Name: Lumacaftor (VX-809)
CAS No.: 936727-05-8
Chemical Name: Lumacaftor (VX-809)
Synonyms: Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;VRT 826809;3-(6-{[1-(2;VX809;VX-809;VX 809, >=98%
CBNumber: CB32489655
Molecular Formula: C24H18F2N2O5
Formula Weight: 452.41
MOL File: 936727-05-8.mol

More

Less

Lumacaftor (VX-809) Property

Melting point:: 200-205oC
Boiling point:: 653.0±55.0 °C(Predicted)
Density: 1.51
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.95±0.10(Predicted)
form: Solid
color: White to Off-White

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

Usbiological

Product number: 273822
Product name: VX-809
Packaging: 50mg
Price: $389
Updated: 2021/12/16

More

Less

Lumacaftor (VX-809) Chemical Properties,Usage,Production

Uses

VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.

Biological Activity

vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several

target

CFTR

Lumacaftor (VX-809) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Lumacaftor (VX-809) Suppliers

China 209 India 6 United States 16 Global 231

ShangHai Onsyn-Chemical Technology Co., Ltd.

Tel: 021-58359326 13124831025
Fax: +86-21-58359326
Email: angsihuaxue@126.com
Country: China
ProdList: 246
Advantage: 55

Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd

Tel: 0311-67591193 15030197620
Fax: QQ:2786999724
Email: sales02@dingminpharma.com
Country: China
ProdList: 299
Advantage: 58

China Shenyang Tyschem CO. ,LTD

Tel: 13889821340
Fax: 024-83607930
Email: tongyuansu@126.com
Country: China
ProdList: 126
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Shanghai Scientia Pharmaceutical Technology Co., Ltd.

Tel: 21-21-54301573 13917723525
Fax: (86)21-51861981
Email: sales@scientiapharm.com
Country: China
ProdList: 263
Advantage: 62

Suzhou Kaiyuan Minsheng Sci&Tech Corp. Ltd.

Tel: 0512-62889106
Fax: 0512-62889106
Email: business@minshengpharm.com
Country: China
ProdList: 110
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5700
Advantage: 66

More

Less

View Lastest Price from Lumacaftor (VX-809) manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.91%
Supply Ability: 200000
Release date: 2024-04-22

Henan Fengda Chemical Co., Ltd

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $0.00/g/Bag
Min. Order: 1g
Purity: 98.0%~102.0%
Supply Ability: 10kg/month
Release date: 2021-06-03

936727-05-8, Lumacaftor (VX-809)Related Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 1H-Pyrrole-2-carboxaMide, 4-[2-[(2-chloro-4-fluorophenyl)aMino]-5-Methyl-4-pyriMidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]- VX 702 Bortezomib Y27632 (hydrochloride) Dasatinib VX-770 VX-661 Ibrutinib

3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid

VX-809

3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid

Lumacaftor

3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid

VRT 826809

CS-719

Lumacaftor(vx-809,vx809)

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)be

VX 809, >=98%

VX-809 (LUMACAFTOR);VX 809

3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl

VX-809 + IVACAFTOR

VX-809 (LuMacaftor)

3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor

VX809;VX-809

3-(6-{[1-(2

Lumacaftor VX809

VX-809, Lumacaftor, VRT 826809

Benzoic acid, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]-

3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropaneca...

3-{6-[1-(2,2-difluoro-1,3-dioxaindan-5-yl)cycloprop aneamido]-3-methylpyridin-2-yl}benzoic acid

3-(6-(1-(2,2-Difluorobenzod1,3dioxol-5-yl)cyclopropane-carboxcarboxamido)-3-methylpyridin-2-yl)-benzoic acid

936727-05-8

Inhibitors

VX-809