VX 702

Biological activity

Product Name: VX 702
CAS No.: 745833-23-2
Chemical Name: VX 702
Synonyms: VX 702;CS-1840;VX702;VX-702;VX-702 ，S6005;VX 702 USP/EP/BP;(479543-46-9) vx 702;VX-702, 10 mM in DMSO;VX-702,VX702,VX 702,Inhibitor,p38 MAPK,inhibit,Autophagy;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
CBNumber: CB02484952
Molecular Formula: C19H12F4N4O2
Formula Weight: 404.32
MOL File: 745833-23-2.mol

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VX 702 Property

Boiling point:: 555.2±60.0 °C(Predicted)
Density: 1.503
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
pka: 10.65±0.50(Predicted)
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 745833-23-2

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2493
Product name: VX-702
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $84.66
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2493
Product name: VX-702
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $314
Updated: 2025/07/31

TCI Chemical

Product number: V0147
Product name: VX-702
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $147
Updated: 2025/07/31

TCI Chemical

Product number: V0147
Product name: VX-702
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $439
Updated: 2025/07/31

Cayman Chemical

Product number: 13108
Product name: VX-702
Purity: ≥95%
Packaging: 5mg
Price: $25
Updated: 2024/03/01

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VX 702 Chemical Properties,Usage,Production

Biological activity

VX-702 is a highly selective p38α MAPK inhibitor, 14-fold more potent against p38α than against p38β. Phase 2.

Description

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (K_d = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC₅₀ values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.

Uses

VX-702 is a p38 mitogen-activated protein kinase (MAPK) inhibitor. VX-702 had no effect on platelet aggregation induced by any of the p38 MAPK agonists. VX-702 has potential use in the treatment of inflammation, rheumatoid arthritis and cardiovascular diseases.

Uses

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]

Definition

ChEBI: 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide is a phenylpyridine.

in vivo

The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally^[2].
VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score^[3].

storage

+4°C

References

[1] DAVID M. GOLDSTEIN*. Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders[J]. Journal of Medicinal Chemistry, 2009, 53 6: 2345-2353. DOI:10.1021/jm9012906
[2] ATHAN KULIOPULOS Lidija C Ramon Mohanlal. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation.[J]. Thrombosis and haemostasis, 2004, 92 6: 1387-1393. DOI:10.1160/th04-03-0187
[3] NEMANJA DAMJANOV George T S G Robert S Kauffman. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies†[J]. Arthritis & Rheumatology, 2009, 60 5: 1232-1241. DOI:10.1002/art.24485
[4] DING C. Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.[J]. Current opinion in investigational drugs, 2006, 7 11: 1020-1025.
[5] ANDREY SKRIPCHENKO. An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion.[J]. PLoS ONE, 2013: e70732. DOI:10.1371/journal.pone.0070732

VX 702 Preparation Products And Raw materials

Raw materials

Preparation Products

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VX 702 Suppliers

Canada 1 China 112 Germany 1 India 3 Japan 1 United Kingdom 3 United States 21 Global 142

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
Advantage: 58

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

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View Lastest Price from VX 702 manufacturers

Weijer International Trade (Hebei) Co., Ltd

Product: VX 702 745833-23-2
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 50000kg/Month
Release date: 2023-03-17

Career Henan Chemical Co

Product: VX 702 745833-23-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-20

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6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide

VX 702

6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702

VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide

VX702;VX-702

2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide

(479543-46-9) vx 702

CS-1840

3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-

VX 702 USP/EP/BP

VX-702,VX702,VX 702,Inhibitor,p38 MAPK,inhibit,Autophagy

VX-702, 10 mM in DMSO

VX-702 ，S6005

745833-23-2

Inhibitors

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators