VX 702
Biological activity- Product Name
- VX 702
- CAS No.
- 745833-23-2
- Chemical Name
- VX 702
- Synonyms
- VX 702;CS-1840;VX702;VX-702;VX 702 USP/EP/BP;(479543-46-9) vx 702;VX-702,VX702,VX 702,Inhibitor,p38 MAPK,inhibit,Autophagy;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702
- CBNumber
- CB02484952
- Molecular Formula
- C19H12F4N4O2
- Formula Weight
- 404.32
- MOL File
- 745833-23-2.mol
VX 702 Property
- Boiling point:
- 555.2±60.0 °C(Predicted)
- Density
- 1.503
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
- pka
- 10.65±0.50(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 745833-23-2
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- V0147
- Product name
- VX-702
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- V0147
- Product name
- VX-702
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $425
- Updated
- 2024/03/01
- Product number
- 13108
- Product name
- VX-702
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 13108
- Product name
- VX-702
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 13108
- Product name
- VX-702
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $107
- Updated
- 2024/03/01
VX 702 Chemical Properties,Usage,Production
Biological activity
VX-702 is a highly selective p38α MAPK inhibitor, 14-fold more potent against p38α than against p38β. Phase 2.
Description
VX-
Uses
VX-702 is a p38 mitogen-activated protein kinase (MAPK) inhibitor. VX-702 had no effect on platelet aggregation induced by any of the p38 MAPK agonists. VX-702 has potential use in the treatment of inflammation, rheumatoid arthritis and cardiovascular diseases.
Uses
VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]
Definition
ChEBI: 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide is a phenylpyridine.
storage
+4°C
References
1) Goldstein?et al.?(2010),?Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders; J. Med. Chem.,?53?2345 2) Kuliopulos?et al.?(2004),?Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation; Thromb. Haemostasis,?92?1387 3) Damianov?et al.?(2009),?Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies; Arthrit. Rheumat.,?60?1232 4) Ding?et al. (2006),?Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome; Curr. Opin. Investig. Drugs,?7?1020 5) Scripchenko?et al.?(2013),?An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion; PLoS One,?8(8)e?70732
VX 702 Preparation Products And Raw materials
Raw materials
Preparation Products
VX 702 Suppliers
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View Lastest Price from VX 702 manufacturers
- Product
- VX 702 745833-23-2
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 50000kg/Month
- Release date
- 2023-03-17
- Product
- VX 702 745833-23-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-20