VX 702

ChemicalBook > CAS DataBase List > VX 702

Biological activity

Product Name: VX 702
CAS No.: 745833-23-2
Chemical Name: VX 702
Synonyms: VX 702;CS-1840;VX702;VX-702;VX 702 USP/EP/BP;(479543-46-9) vx 702;VX-702,VX702,VX 702,Inhibitor,p38 MAPK,inhibit,Autophagy;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702
CBNumber: CB02484952
Molecular Formula: C19H12F4N4O2
Formula Weight: 404.32
MOL File: 745833-23-2.mol

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VX 702 Property

Boiling point:: 555.2±60.0 °C(Predicted)
Density: 1.503
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
pka: 10.65±0.50(Predicted)
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 745833-23-2

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: V0147
Product name: VX-702
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $142
Updated: 2024/03/01

TCI Chemical

Product number: V0147
Product name: VX-702
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $425
Updated: 2024/03/01

Cayman Chemical

Product number: 13108
Product name: VX-702
Purity: ≥95%
Packaging: 5mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 13108
Product name: VX-702
Purity: ≥95%
Packaging: 10mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 13108
Product name: VX-702
Purity: ≥95%
Packaging: 25mg
Price: $107
Updated: 2024/03/01

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VX 702 Chemical Properties,Usage,Production

Biological activity

VX-702 is a highly selective p38α MAPK inhibitor, 14-fold more potent against p38α than against p38β. Phase 2.

Description

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (K_d = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC₅₀ values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.

Uses

VX-702 is a p38 mitogen-activated protein kinase (MAPK) inhibitor. VX-702 had no effect on platelet aggregation induced by any of the p38 MAPK agonists. VX-702 has potential use in the treatment of inflammation, rheumatoid arthritis and cardiovascular diseases.

Uses

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]

Definition

ChEBI: 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide is a phenylpyridine.

storage

+4°C

References

1) Goldstein?et al.?(2010),?Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders; J. Med. Chem.,?53?2345 2) Kuliopulos?et al.?(2004),?Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation; Thromb. Haemostasis,?92?1387 3) Damianov?et al.?(2009),?Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies; Arthrit. Rheumat.,?60?1232 4) Ding?et al. (2006),?Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome; Curr. Opin. Investig. Drugs,?7?1020 5) Scripchenko?et al.?(2013),?An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion; PLoS One,?8(8)e?70732

VX 702 Preparation Products And Raw materials

Raw materials

Preparation Products

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VX 702 Suppliers

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View Lastest Price from VX 702 manufacturers

Weijer International Trade (Hebei) Co., Ltd

Product: VX 702 745833-23-2
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 50000kg/Month
Release date: 2023-03-17

Career Henan Chemical Co

Product: VX 702 745833-23-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-20

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6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide

VX 702

6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702

VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide

VX702;VX-702

2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide

(479543-46-9) vx 702

CS-1840

3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-

VX 702 USP/EP/BP

VX-702,VX702,VX 702,Inhibitor,p38 MAPK,inhibit,Autophagy

745833-23-2

Inhibitors

Aromatics

Heterocycles

Intermediates & Fine Chemicals

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Protein Kinase Inhibitors and Activators