Lumacaftor (VX-809)
- Product Name
- Lumacaftor (VX-809)
- CAS No.
- 936727-05-8
- Chemical Name
- Lumacaftor (VX-809)
- Synonyms
- Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;VRT 826809;3-(6-{[1-(2;VX809;VX-809;VX 809, >=98%
- CBNumber
- CB32489655
- Molecular Formula
- C24H18F2N2O5
- Formula Weight
- 452.41
- MOL File
- 936727-05-8.mol
Lumacaftor (VX-809) Property
- Melting point:
- 200-205oC
- Boiling point:
- 653.0±55.0 °C(Predicted)
- Density
- 1.51
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.95±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22196
- Product name
- VX-809
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 22196
- Product name
- VX-809
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 22196
- Product name
- VX-809
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- 22196
- Product name
- VX-809
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $573
- Updated
- 2024/03/01
- Product number
- 273822
- Product name
- VX-809
- Packaging
- 50mg
- Price
- $389
- Updated
- 2021/12/16
Lumacaftor (VX-809) Chemical Properties,Usage,Production
Uses
VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.
Biological Activity
vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several
target
CFTR
Lumacaftor (VX-809) Preparation Products And Raw materials
Raw materials
Preparation Products
Lumacaftor (VX-809) Suppliers
View Lastest Price from Lumacaftor (VX-809) manufacturers
- Product
- Lumacaftor (VX-809) 936727-05-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.91%
- Supply Ability
- 200000
- Release date
- 2024-04-22
- Product
- Lumacaftor (VX-809) 936727-05-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- Lumacaftor (VX-809) 936727-05-8
- Price
- US $0.00/g/Bag
- Min. Order
- 1g
- Purity
- 98.0%~102.0%
- Supply Ability
- 10kg/month
- Release date
- 2021-06-03