ChemicalBook > CAS DataBase List > Lumacaftor (VX-809)

Lumacaftor (VX-809)

Product Name
Lumacaftor (VX-809)
CAS No.
936727-05-8
Chemical Name
Lumacaftor (VX-809)
Synonyms
Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;VRT 826809;3-(6-{[1-(2;VX809;VX-809;VX 809, >=98%
CBNumber
CB32489655
Molecular Formula
C24H18F2N2O5
Formula Weight
452.41
MOL File
936727-05-8.mol
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Lumacaftor (VX-809) Property

Melting point:
200-205oC
Boiling point:
653.0±55.0 °C(Predicted)
Density 
1.51
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
3.95±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22196
Product name
VX-809
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
22196
Product name
VX-809
Purity
≥98%
Packaging
5mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
22196
Product name
VX-809
Purity
≥98%
Packaging
10mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
22196
Product name
VX-809
Purity
≥98%
Packaging
25mg
Price
$573
Updated
2024/03/01
Usbiological
Product number
273822
Product name
VX-809
Packaging
50mg
Price
$389
Updated
2021/12/16
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Lumacaftor (VX-809) Chemical Properties,Usage,Production

Uses

VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.

Biological Activity

vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several

target

CFTR

Lumacaftor (VX-809) Preparation Products And Raw materials

Raw materials

Preparation Products

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Lumacaftor (VX-809) Suppliers

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View Lastest Price from Lumacaftor (VX-809) manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Lumacaftor (VX-809) 936727-05-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99.91%
Supply Ability
200000
Release date
2024-04-22
Henan Fengda Chemical Co., Ltd
Product
Lumacaftor (VX-809) 936727-05-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lumacaftor (VX-809) 936727-05-8
Price
US $0.00/g/Bag
Min. Order
1g
Purity
98.0%~102.0%
Supply Ability
10kg/month
Release date
2021-06-03

936727-05-8, Lumacaftor (VX-809)Related Search:

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  • 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid
  • VX-809
  • 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid
  • Lumacaftor
  • 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid
  • VRT 826809
  • CS-719
  • Lumacaftor(vx-809,vx809)
  • 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)be
  • VX 809, >=98%
  • VX-809 (LUMACAFTOR);VX 809
  • 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid
  • 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl
  • VX-809 + IVACAFTOR
  • VX-809 (LuMacaftor)
  • 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor
  • VX809;VX-809
  • 3-(6-{[1-(2
  • Lumacaftor VX809
  • VX-809, Lumacaftor, VRT 826809
  • Benzoic acid, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]-
  • 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropaneca...
  • 3-{6-[1-(2,2-difluoro-1,3-dioxaindan-5-yl)cycloprop aneamido]-3-methylpyridin-2-yl}benzoic acid
  • 3-(6-(1-(2,2-Difluorobenzod1,3dioxol-5-yl)cyclopropane-carboxcarboxamido)-3-methylpyridin-2-yl)-benzoic acid
  • 936727-05-8
  • Inhibitors
  • VX-809