Description References
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Micafungin

Description References
Product Name
Micafungin
CAS No.
235114-32-6
Chemical Name
Micafungin
Synonyms
Micfungin;MICAFUNGIN;Micafungin Na;Micafungin-d11;Micafungin (Acid);PubChem ID: 477468;PubChem ID: 3081921;PubChem ID: 11804463;PubChem ID: 78357831;Micafungin USP/EP/BP
CBNumber
CB71471028
Molecular Formula
C56H71N9O23S
Formula Weight
1270.28
MOL File
235114-32-6.mol
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Micafungin Property

Melting point:
>198oC (dec.)
Density 
1.62±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Very Slightly, Heated)
pka
-4.46±0.18(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
456203
Product name
Micafungin
Packaging
5mg
Price
$319
Updated
2021/12/16
TRC
Product number
M342345
Product name
Micafungin
Packaging
250mg
Price
$365
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006238
Product name
MICAFUNGIN
Purity
95.00%
Packaging
5MG
Price
$498.73
Updated
2021/12/16
AvaChem
Product number
2670
Product name
Micafungin
Packaging
1g
Price
$1250
Updated
2021/12/16
AvaChem
Product number
2670
Product name
Micafungin
Packaging
250mg
Price
$475
Updated
2021/12/16
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Micafungin Chemical Properties,Usage,Production

Description

Micafungin (trade name Mycamine) is a kind of echinocandin antifungal drug. Its mechanism of action is through inhibiting the synthesis of beta-1, 3-glucan, which is an essential component of fungal cell walls, but not presented in mammalian cells. It works through inhibiting the beta-1,3-D glucan synthase. It can be used for the treatment of candidemia, acute disseminated candidiasis, candida peritonitis, abscesses and esophageal candidiasis. It is fungicidal against some candida, but fungistatic against Apergillus. It is also used in combinations with many other drugs such as the HIV protease inhibitor ritonavir as well as the transplant medications cyclosporine and tacrolimus.

References

https://www.drugbank.ca/drugs/DB01141
https://en.wikipedia.org/wiki/Micafungin

Description

Micafungin, the second member of the echinocandin class of antifungal agents was launched in Japan for the parenteral treatment of various fungal infections caused by Aspergillus and Candida spp. such as fungaemia and respiratory and gastrointestinal mycoses. This water-soluble semisynthetic cyclic lipopeptide is synthesized by acylation with (5-(4- pentyloxyphenyl)isoxazol-3-yl)benzoate of the cyclic peptide nucleus (FR-179642).obtained by enzymatic cleavage of the naturally occurring echinocandin FR-901379, derived from the fungus Coleophoma empedri Micafungin acts by inhibiting the synthesis of 1,3-beta-glucan, an essential polysaccharide of the cell wall of many pathogenic fungi. Micafungin has a marked fungicidal effect on almost all species of Candida, including fluconazole-resistant spp. C. albicans, C. glabrata, C. Krusei, C. parapsilosis and C. tropicalis and a fungistatic effect on a range of Aspergillus species including A. flaws, A. fumigates and A. terreus. Like caspofungin, micafungin is inactive against Cryptococcus neoformans, and the emerging pathogen Trichosporon cutaneum and Fusarium solani. Micafungin has proved highly effective in mouse models of Cancfidiasis and Aspergillus infections (including those using an amphotericin B- and itraconazole-resistant isolate of A. fumigatus). In phase I studies, micafungin had linear pharmacokinetics with an elimination half-life ranging from 11.7 to 15.2 h after injection and was well tolerated.

Originator

Fujisawa (Japan)

Uses

Micafungin is an antifungal drug that inhibits the production of β-1,3-glucan, an essential component of fungal cell walls.

Uses

An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.

Uses

Micafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1999 from Fujisawa in Japan. Unlike other marketed semi-synthetic derivatives in this class, micafungin is not derived from echinocandin but rather from FR901379 which contains a phenolic sulphate to enhance aqueous solubility, a serious limitation in the class. Micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively referenced in the literature with over 700 citations.

Definition

ChEBI: A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invas ve candidiasis, and of aspergillosis in patients who are intolerant of other therapy.

brand name

Mycamine(Astellas);Funguard.

Antimicrobial activity

It is active against Aspergillus spp., Candida spp. and the cyst form of Pn. jirovecii. Resistance has rarely been reported.

Pharmaceutical Applications

A semisynthetic lipopeptide derived from a fermentation product of Coleophoma empetri. Formulated as the monosodium salt for intravenous infusion.

Pharmacokinetics

Cmax 50 mg 1-h infusion: c. 5 mg/L 1 h post infusion
Plasma half-life: 11–15 h
Volume of distribution: 0.4 L/kg
Plasma protein binding: 99%
Blood concentrations increase in proportion to dosage. Unlike anidulafungin and caspofungin, a loading dose is not required.
Distribution
The drug is widely distributed, the highest concentrations being found in the liver. Levels in the CSF and urine are negligible.
Metabolism and excretion
It is metabolized by the liver and the three inactive metabolites are excreted in the feces (70%). Less than 1% of a dose is eliminated as unchanged drug in the urine. No dosage adjustment is required in patients with severe renal impairment or mild to moderate hepatic impairment. The effect of severe hepatic impairment on micafungin pharmacokinetics has not been studied. Micafungin is not cleared by hemodialysis.

Clinical Use

Candidemia and certain invasive forms of candidosis
Esophageal candidosis
Prophylaxis of Candida infections in hematopoietic stem cell transplant (HSCT) recipients

Side effects

Occasional histamine-mediated infusion-related reactions, injection site reactions and transient abnormalities of liver enzymes have been reported. Isolated cases of significant hepatic or renal dysfunction, hepatitis, or liver or renal failure have also been described.

Drug interactions

Potentially hazardous interactions with other drugs
Ciclosporin: possibly increases ciclosporin concentration.
Sirolimus: increases sirolimus concentration.

Metabolism

Metabolised in the liver by arylsulfatase to its catechol form and further metabolised to the methoxy form by catechol-O-methyltransferase. Some hydroxylation to micafungin via cytochrome P450 isoenzymes also occurs. Exposure to these metabolites is low and metabolites do not contribute to the overall efficacy of micafungin. After 28 days about 71% of a dose is recovered in the faeces and 12% in the urine.

Micafungin Preparation Products And Raw materials

Raw materials

Preparation Products

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Micafungin Suppliers

Cangzhou Weizhidamei Pharmaceutical Co., Ltd.
Tel
13426038769 13426038769
Fax
0317-5486999
Email
askmryu@163.com
Country
China
ProdList
59
Advantage
58
SHANG HAI WEI LING BIOTECHNOLOGY CO.,LTD
Tel
13917490980
Email
81939905@qq.com
Country
China
ProdList
315
Advantage
58
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4505
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17944
Advantage
56
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View Lastest Price from Micafungin manufacturers

Wuhan Biocar Pharmacy Co., Ltd.
Product
Micafungin 235114-32-6
Price
US $199.90-199.90/g
Min. Order
1g
Purity
99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
Supply Ability
1kg
Release date
2022-09-27
Shaanxi Haibo Biotechnology Co., Ltd
Product
Micafungin 235114-32-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-06
Hebei Guanlang Biotechnology Co,.LTD
Product
Micafungin 235114-32-6
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-06-16

235114-32-6, MicafunginRelated Search:


  • MICAFUNGIN
  • Micfungin
  • PubChem ID: 11804463
  • PubChem ID: 122130057
  • PubChem ID: 477468
  • PubChem ID: 78357831
  • PubChem ID: 3081921
  • Micafungin (Acid)
  • PneuMocandin A0,1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-
  • Micafungin-d11
  • Micafungin Na
  • Micafungin USP/EP/BP
  • Micafungin(free acid)
  • TIANFU-CHEM Micafungin
  • Pneumocandin A0,1-[(4R,5R)-4,
  • 2H11]-Micafungin Sodium salt
  • 235114-32-6
  • C56H71N9O23S
  • API
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Heterocycles
  • Antifungals
  • 235114-32-6