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Caspofungin acetate

Product Name
Caspofungin acetate
CAS No.
179463-17-3
Chemical Name
Caspofungin acetate
Synonyms
Cancidas;Caspofungin Diacetate;(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate;Mk0991;Mk 0991;L 743872;L-743872;L 743873;L 743,872;L-743,872
CBNumber
CB51120146
Molecular Formula
C54H92N10O17
Formula Weight
1153.38
MOL File
179463-17-3.mol
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Caspofungin acetate Property

Melting point:
>105°C (dec.)
storage temp. 
-20°C
solubility 
H2O: soluble15mg/mL (clear solution)
form 
powder
color 
white to beige
InChIKey
OGUJBRYAAJYXQP-LLXMLGLCSA-N
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Safety

WGK Germany 
3
RTECS 
TP8046500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0425
Product name
Caspofungin diacetate
Purity
≥97% (HPLC)
Packaging
5mg
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0425
Product name
Caspofungin diacetate
Purity
≥97% (HPLC)
Packaging
25mg
Price
$451
Updated
2024/03/01
Cayman Chemical
Product number
15923
Product name
Caspofungin (acetate)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15923
Product name
Caspofungin (acetate)
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
15923
Product name
Caspofungin (acetate)
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
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Caspofungin acetate Chemical Properties,Usage,Production

Description

Caspofungin is the first in a new class of antifungal agents named echinocandin to be launched in the US for the parenteral treatment of invasive aspergillosis in patients refractory to, or intolerant of other antifungal therapies such as amphotericin-B1 lipid formulation of amphotericin-B and/or itraconazole. Caspofungin is a water soluble, stable, aza-substituted semisynthetic derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. Since fungi and humans are both eukaryotes, new antifungal agents must focus on fungus-specific targets in order to minimize potential toxicity in the human host. In this respect, the lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin has activity in vitro and in vivo against a range of Candida species (including azole and amphotericin B resistant Candida) and also against Aspergillus, an important pathogen which is not susceptible to fluconazole. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species. Cryptococcus is not susceptible to caspofungin. Caspofungin has a half-life in human beings around 10 hours. Unlike the azoles, caspofungin does not inhibit cytochrome P450. The drug has been given intravenously with loading dose of 70 rag, followed by 50 mg daily to be effective in invasive aspergillosis refractory to prior antifungal therapy. Most of the side effects were mild and comprised fever, thrombophlebitis, headache, nausea, rash and flushing.

Description

Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall. It is effective against disseminated or invasive aspergillosis and candidiasis in mice. Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml. It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.

Chemical Properties

White Solid

Originator

Merck & Co (US)

Uses

Calcium antagonist, coronary vasodilator, anti-inflammatory, analgesic

Uses

Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

Uses

Caspofungin acetate is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.

brand name

Cancidas (Merck).

Biochem/physiol Actions

Caspofungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthase, which is required for cell wall synthesis, thereby disturbing the integrity of the fungal cell wall.

Veterinary Drugs and Treatments

Caspofungin has potential for treating invasive aspergillosis or disseminated candidal infections in companion animals although little, if any, information on its use in dogs or cats is available.

Caspofungin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Caspofungin acetate Suppliers

Canada 1 China 306 India 16 Israel 1 South Korea 1 United Kingdom 1 United States 20 Global 346
Hubei wei shi reagent group ltd., company
Tel
186-27096350 18627096350
Fax
027-59379337
Email
2853877630@qq.com
Country
China
ProdList
2666
Advantage
58
Shanghai Linka Biotechnology Co., Ltd.
Tel
15901858719
Fax
qq2126935757
Email
2126935757@qq.com
Country
China
ProdList
311
Advantage
55
BrightGene Bio-medical Technology Co., Ltd.
Tel
0512-0512-62551764 18013103761
Fax
0512-62551799
Email
sales01@bright-gene.com
Country
China
ProdList
61
Advantage
70
Shanghai Hanjing Chemicals Co., Ltd.
Tel
021-54285032 13641685631
Fax
+86 (21) 5443 7651
Email
gerry.shu@hanjingchemicals.com
Country
China
ProdList
76
Advantage
55
Taizhou Crene Biotechnology Co. Ltd.
Tel
0576-88813233 13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
2013
Advantage
58
Jiangsu raspberry International Trade Co., Ltd.
Tel
18507340638
Email
2335663646@qq.com
Country
China
ProdList
225
Advantage
58
Wuhan Dingxintong Pharmaceutical Co. , Ltd.
Tel
027-027-83984790 17720532645
Fax
027-83984790
Email
t17720532645@163.com
Country
China
ProdList
992
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
995
Advantage
59
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View Lastest Price from Caspofungin acetate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Caspofungin acetate 179463-17-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Shaanxi Haibo Biotechnology Co., Ltd
Product
Caspofungin Acetate 179463-17-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-04
Wuhan Boyuan Import & Export Co., LTD
Product
Caspofungin acetate 179463-17-3
Price
US $500.00/KG
Min. Order
10KG
Purity
99.50%
Supply Ability
1000kg
Release date
2023-02-16

179463-17-3, Caspofungin acetateRelated Search:

Acetic acid Tocopheryl acetate S-Adenosyl-L-methionine Sodium acetate trihydrate Sodium acetate Butyl acetate Potassium Acetate Ethyl acetate Glatiramer acetate Methyl acetate Caspofungin Vinyl acetate ACETATE Caspofungin acetate

  • Casp ungin Acetate
  • Caspofungin acetate
  • (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate
  • Cancidas
  • Caspofungin acetate [USAN:BAN:JAN]
  • Caspofungin Acetate (L 743872
  • Caspofungin Acetate for lnjection
  • Cancidas, ≥98%
  • Casporfungin Acetate
  • CF/KB(EUGMP,GMP)
  • L 743872;L 743873;MK 0991;MK-0991
  • L 743,872
  • L 743872
  • L-743,872
  • L-743872
  • Mk 0991
  • Mk0991
  • Pneumocandin B0, 1-((4R,5S)-5-((2-aminoethyl)amino)-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine)-5-((3R)-3-hydroxy-L-ornithine)-, diacetate (salt)
  • 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneuMocandin B0 Diacetate
  • 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneuMocandin B0 Diacetate
  • Caspofungin Diacetate
  • L 743873
  • Cancidas, L-743,872, MK-0991
  • Cancidas (Caspofungin Acetate)
  • Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)
  • (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1
  • Caspofungin acetate Cancidas
  • 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0
  • Caspofungin diacetate, >=98%
  • Caspofungin acetate USP/EP/BP
  • Caspofungin diacetate salt
  • Caspofungin acetate B0
  • pofungin Acetate
  • (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate
  • Caspofungin Acetate (MK0991)
  • (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrol
  • US-DMF No.: 034091 ASMF Approved
  • Bamifylline Impurity 2
  • Caspofungin Acetate (>90%)
  • Carpofungin acetate
  • Gaspofungin Acetate
  • (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide acetate
  • (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate
  • 179463-17-3
  • 179643-17-3
  • 79463-17-3
  • C56H96N10O19
  • C52H88N10O152C2H4O2
  • API
  • Amines
  • Heterocycles
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  • Intermediates & Fine Chemicals
  • Pharmaceuticals