description Safety and Side Effects
ChemicalBook > CAS DataBase List > S-Adenosyl-L-methionine

S-Adenosyl-L-methionine

description Safety and Side Effects
Product Name
S-Adenosyl-L-methionine
CAS No.
29908-03-0
Chemical Name
S-Adenosyl-L-methionine
Synonyms
SAM;ADEMETIONINE;SAM-E;SAM-B;p-Toluenesulfonate salt;Ademetionin;adenosylmethionine;S-Adenosyl-L-methionine USP/EP/BP;Ademetionine(b);methioninyladenylate
CBNumber
CB1384167
Molecular Formula
C15H22N6O5S
Formula Weight
398.44
MOL File
29908-03-0.mol
More
Less

S-Adenosyl-L-methionine Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly, Sonicated), Water (Slightly)
form 
Solid
color 
White to Yellow
Stability:
Very Hygroscopic
InChIKey
MEFKEPWMEQBLKI-WGIZDKKNNA-N
SMILES
O[C@@H]1[C@@H]([C@@H](C[S+](C)CC[C@H](N)C(=O)[O-])O[C@H]1N1C=NC2C(=NC=NC1=2)N)O |&1:1,2,3,9,15,r|
CAS DataBase Reference
29908-03-0(CAS DataBase Reference)
More
Less

Safety

Risk Statements 
49-23-34
Safety Statements 
53-23-36/37/39-45
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
295324
Product name
S-Adenosyl-L-methionine
Packaging
25mg
Price
$213
Updated
2021/12/16
Activate Scientific
Product number
AS33422
Product name
S-Adenosyl-L-methionine HCl
Purity
98+% ee
Packaging
1g
Price
$281
Updated
2021/12/16
ChemScene
Product number
CS-2851
Product name
S-Adenosyl-L-methionine
Purity
≥98.0%
Packaging
100mg
Price
$450
Updated
2021/12/16
Biosynth Carbosynth
Product number
NA16291
Product name
S-Adenosyl-L-methionine
Packaging
50mg
Price
$210
Updated
2021/12/16
Ambeed
Product number
A132774
Product name
(2S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate
Purity
98+%
Packaging
1g
Price
$20
Updated
2021/12/16
More
Less

S-Adenosyl-L-methionine Chemical Properties,Usage,Production

description

S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. SAMe is sold in the United States as a dietary supplement.
S-Adenosyl-L-methionine was discovered in the early 1950s. It’s made in the body from methionine, an amino acid found in foods. It has been found to regulate key functions in living cells.
Abnormal levels of S-Adenosyl-L-methionine in the body have been reported in liver diseases and depression. This prompted researchers to investigate whether S-Adenosyl-L-methionine might be helpful in treating these conditions. The idea that S-Adenosyl-L-methionine might be helpful for osteoarthritis came from studies of S-Adenosyl-L-methionine for depression. Some of the participants in the depression studies who also had osteoarthritis said their joint symptoms improved when they took S-Adenosyl-L-methionine.

Safety and Side Effects

Information on the long-term safety of S-Adenosyl-L-methionine is limited because the participants in most studies took it only for short periods of time. However, in one study of alcohol-related liver disease, participants took S-Adenosyl-L-methionine for 2 years; in that study, no serious side effects were reported.
People with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not take SAMe for their depressive symptoms except under the supervision of a health care provider because SAMe may worsen symptoms of mania.
Although S-Adenosyl-L-methionine has been used to treat cholestasis during pregnancy, its safety during pregnancy has not been established.
SAMe may decrease the effects of levodopa (L-dopa), a drug used to treat Parkinson’s disease. It’s also possible that SAMe might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort.
There’s a theoretical concern about the use of SAMe by people who are immunocompromised (such as those who are HIV-positive). Immunocompromised people are at risk for Pneumocystis carinii infection, and SAMe enhances the growth of this microorganism.
Side effects of SAMe are uncommon, and when they do occur they are usually minor problems such as nausea or digestive upsets.

Originator

Donamet ,Ravizza

Occurrence

SAM-e is found in all living cells and is a precursor in some amino acids.

Uses

white powder LOD 0.2%

Definition

ChEBI: S-adenosyl-L-methioninate is a sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group. It has a role as a human metabolite. It is functionally related to a L-methioninate. It is a conjugate base of a S-adenosyl-L-methionine.

Manufacturing Process

S-Adenosyl methionine (SAM) is produced is prepared by cultivating of Saccharomyces cerevisiae.
One loopful of each of the microorganism strains (IFO 2342, IFO 2343, IFO 2345, IFO 2346, IFO 2347) was inoculated in 10 ml of a heat-sterilized culture medium adjusted to pH 6.0 and composed of 5.0 g/dl of glucose, 0.5 g/dl of polypeptone, 0.4 g/dl of KH2PO4, 0.4 g/dl of K2HPO4, 0.02 g/dl of MgSO4·7H2O and 0.2 g/dl of yeast extract, and cultivated with shaking at 28°C for 24 h.
1 L of a culture medium adjusted to pH 6.0 and composed of 10.0 g/dl of sucrose, 1.0 g/dl of yeast extract, 0.4 g/dl of K2HPO4, 0.01 g/dl of MgSO4·7H2O, 1.5 g/dl of urea (separately sterilized), 0.75 g/dl of Lmethionine, 0.02 g/dl of CaCl2·2H2O, 0.25 mg/dl of ZnSO4·7H2O, 0.25 mg/dl of FeSO4·7H2O, 125.0 mg/dl of MnSO4·6H2O, 2.0 μg/dl of CuSO4·5H2O, 2.0 μg/dl of H3BO3, 0.2 μg/dl of CoCl2·6H2O and 1.0 μg/dl of KI was put in a 2- liter fermentor and sterilized. Then, 5 ml of the seed culture broth prepared as above was inoculated in the culture medium and cultivated at 28°C for 72 h with aeration and agitation.
After the cultivation, the microbial cells were collected by centrifugal separation, washed once with physiological saline, suspended in 100 ml of 1.5 N perchloric acid, and shaken at room temperature for 1 h. The suspension was then centrifuged to remove the microbial cells, and the resulting liquid was adjusted to pH 4.5 by adding potassium hydrogen carbonate. The resulting precipitate of potassium perchlorate was removed by centrifugal separation to give an extract containing SAM. The amount of SAM in the extract was determined, and the amount of SAM based on the dry cells.
The extract in an amount of 0.2 g as SAM was passed through a column filled with 50 ml of Amberlite IRC-50 (H+ form), a weakly acidic cation exchange resin, to cause adsorption of SAM. 0.005 N acetic acid was passed through the column to wash it until the absorbance at 260 nm of the eluate becames less than 0.1. Thus, impurities were removed. Then, 0.1 N sulfuric acid was passed through the column, and SAM was eluted until the absorbance at 260 nm of the eluate becames less than 0.05. The eluate was treated with Amberlite IRA 900 resin (OH- form) to adjust its pH to 3.0, and then lyophilized to obtain SAM sulfate. The SAM based may be produced from SAM sulfate by treatment with potassium hydrogen carbonate. The purity of SAM was measured by cellulose thin-layer chromatography, paper chromatography and high-performance liquid chromatography. The yield of SAM based on the dry cells: IFO 2343-12.1%; IFO 2346-18.8%; IFO 2347-16.7%.

Therapeutic Function

Metabolic, Antiinflammatory

benefits

S-Adenosyl-L-methionine (SAMe) plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals like serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce SAMe levels in your body. Several studies show that SAMe helps relieve the pain of osteoarthritis. Taking SAMe by mouth works, as well as ibuprofen and other similar drugs for reducing symptoms of osteoarthritis. Other studies suggest that SAMe may help treat depression.

S-Adenosyl-L-methionine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

S-Adenosyl-L-methionine Suppliers

Shanghai Ruili Spectrum Biotechnology Co., Ltd
Tel
021-64705760 18027310741
Email
1060496435@qq.com
Country
China
ProdList
4566
Advantage
58
Kono Chem Co.,Ltd
Tel
029-86107037-8009 13279399072
Fax
13279399072
Email
info@konochemical.com
Country
China
ProdList
732
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
495745175@qq.com
Country
China
ProdList
7981
Advantage
58
Xi'an Jianglin Biotechnology Co., Ltd
Tel
18292036798; 18292036798
Email
JLSW00@163.com
Country
China
ProdList
32
Advantage
58
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
More
Less

View Lastest Price from S-Adenosyl-L-methionine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
S-Adenosyl-L-methionine 29908-03-0
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
95%-105%
Supply Ability
100KGS
Release date
2021-07-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
S-Adenosyl-L-methionine 29908-03-0
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-04-23
Hebei Weibang Biotechnology Co., Ltd
Product
S-Adenosyl-L-methionine 29908-03-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

29908-03-0, S-Adenosyl-L-methionineRelated Search:


  • ADEMETIONINE
  • S-ADENOSYL-L-METHIONINE
  • SAM-E
  • adenosine,5’-((l-3-amino-3-carboxypropyl)methylsulfonio)-5’-deoxy-,hydroxide,
  • adenosylmethionine
  • methioninyladenylate
  • p-Toluenesulfonate salt
  • ADEMETHIOINEDISULFATETOSYLATE
  • (3-amino-3-carboxy-propyl)-[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl]-methyl-sulfanium
  • (3S)-5'-[(3-Amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine
  • SAM
  • S-(5'-desoxyadenosin-5'-y1) methionine
  • (5'-Adenosyl)[(S)-3-amino-3-carboxylatopropyl](methyl)sulfonium
  • 5'-[[(S)-3-Amino-3-carboxylatopropyl]methylsulfonio]-5'-deoxyadenosine
  • S-Adenosyl-L-methion
  • Ademetionin
  • SAM-B
  • S-adenosyl-L-methioninate
  • Ademetionine1,4-Butanedisulfonate for Injection
  • Ademetionine(b)
  • Ademetionine 1,4-Butanedisulfonate Impurity 10
  • S-Adenosyl-L-methionine USP/EP/BP
  • Pharmaceutical Chemical CAS?29908-03-0?Ademetionine
  • Butanedisulfonate Ademetionine Impurity 6
  • S-adenosyl-L-methionine(Ademetionine)
  • ADENOSYL-L-METHIONINE P-TOLUENESULFONATE, S-
  • S-Adenosyl-L-methionine(Isomeric mixture)
  • 29908-03-0
  • 29908-03-8
  • C15H24N6O5S
  • C15H23N6O5S
  • Nutritional Supplements
  • API