Adenosine Deaminase
- Product Name
- Adenosine Deaminase
- CAS No.
- 9026-93-1
- Chemical Name
- Adenosine Deaminase
- Synonyms
- ADENOSINE DEAMINASE;C:C&B7;EC 3.5.4.4;ADENOSINE DEMINASE;deaminase,adenosine;EC 3.5.4.4 USP/EP/BP;Adenosine Deaminase ADA;Retinol Binding Protcin;Deoxyadenosine deaminase;AdenosinedeaMinaseTypeII
- CBNumber
- CB8351045
- Formula Weight
- 0
- MOL File
- Mol file
Adenosine Deaminase Property
- storage temp.
- 2-8°C
- solubility
- Buffered aqueous glycerol solution
- form
- solution (clear)
- color
- pale yellow
- biological source
- bovine spleen
- Water Solubility
- water: miscible
- Specific Activity
- 150-200units/mg protein
N-Bromosuccinimide Price
- Product number
- A5168
- Product name
- Adenosine Deaminase from bovine spleen
- Purity
- Type IX, ammonium sulfate suspension, 150-200?units/mg protein
- Packaging
- 250units
- Price
- $516
- Updated
- 2025/07/31
- Product number
- A5168
- Product name
- Adenosine Deaminase from bovine spleen
- Purity
- Type IX, ammonium sulfate suspension, 150-200?units/mg protein
- Packaging
- 1000units
- Price
- $1750
- Updated
- 2025/07/31
- Product number
- A5043
- Product name
- Adenosine Deaminase from bovine spleen
- Purity
- Type X, buffered aqueous glycerol solution, ≥130?units/mg protein
- Packaging
- 250units
- Price
- $513
- Updated
- 2025/07/31
- Product number
- A5043
- Product name
- Adenosine Deaminase from bovine spleen
- Purity
- Type X, buffered aqueous glycerol solution, ≥130?units/mg protein
- Packaging
- 1000units
- Price
- $1660
- Updated
- 2025/07/31
- Product number
- 169917
- Product name
- Adenosine Deaminase
- Packaging
- 50ug
- Price
- $589
- Updated
- 2021/12/16
Adenosine Deaminase Chemical Properties,Usage,Production
Description
Adenosine deaminase (ADA) is a purine catabolic enzyme ubiquitous in mammalian tissue which catalyzes deamination of both adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine respectively.
ADA is a class of nucleoside catabolic enzymes with significant links to the body's cellular immune system, comprising a group of thiol-containing hydrolases. ADA plays a pivotal role in purine nucleotide catabolism, catalysing the degradation of adenosine nucleosides into inosine nucleosides. These inosine nucleosides are subsequently phosphorylated by nucleoside phosphorylase into inosine, which is ultimately oxidised into the metabolic product uric acid.
ADA is widely distributed throughout the body, with the highest levels found in the thymus, spleen, and other lymphoid tissues. It is also present in the liver, kidneys, skeletal muscle, and lungs. In peripheral blood, lymphocytes and monocytes show the highest enzymatic activity. The activity in red blood cells and granulocytes is 40–70 times greater than that in serum, with T lymphocytes exhibiting higher activity than B lymphocytes.
Gel electrophoresis can distinguish between the ADA1, ADA2, and ADA2‑1 subtypes, whose phenotypes are controlled by the ADA1 and ADA2 alleles on chromosome 20. Typing can generally be performed using three-month-old blood spots. Among the Han Chinese population in China, ADA1 accounts for about 95% of cases, while among ethnic minorities it constitutes approximately 84%. The ability to distinguish individual ADA subtypes remains relatively limited.
Chemical Properties
White amorphous powder
Uses
Adenosine deaminase is useful in various molecular biology assays, such as glycerol release assays . Adenosine deaminase is a potential target for treatments of combined immunodeficiency disease.
Uses
Adenosine deaminase has been used to pre-treat primary Kupffer cells.
Biological Functions
Adenosine deaminase(EC 3.5.4.4), found in a wide variety of microorganisms, plants, invertebrates, and animals, plays a role in purine metabolism.
General Description
Molecular weight: 32.5-33 kDa
pI: 4.85
Biochem/physiol Actions
Adenosine deaminase is a purine catabolic enzyme which catalyzes the deamination of adenosine and 2′-deoxyadenosine with approximately equal specificity. It is ubiquitous in mammalian tissue, and deficiency in adenosine deaminase has been associated with severe combined immunodeficiency disease.
References
[1] KURATA N. [Adenosine deaminase].[J]. Nihon rinsho. Japanese journal of clinical medicine, 1995, 53 5: 1178-1183.
[2] N. SPENCER HARRY H D A HOPKINSON. Adenosine deaminase polymorphism in man[J]. Annals of Human Genetics, 1968, 32 1: 9-14. DOI:10.1111/j.1469-1809.1968.tb00044.x.
[3] D A CARSON J E S J Kaye. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).[J]. Proceedings of the National Academy of Sciences of the United States of America, 1977, 74 12: 5677-5681. DOI:10.1073/pnas.74.12.5677.
[4] QIU-LI LIANG. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A meta-analysis[J]. Respiratory medicine, 2008, 102 5: Pages 744-754. DOI:10.1016/j.rmed.2007.12.007.
[5] J. UNGERER. Serum adenosine deaminase: isoenzymes and diagnostic application.[J]. Clinical chemistry, 1992, 99 1: 1322-1326. DOI:10.1093/CLINCHEM/38.7.1322.
[6] LIQIAO HAN . Optimization of an enzyme-coupling method by spectrophotometer for serum adenosine deaminase: As a candidate reference method[J]. Analytical biochemistry, 2019, 587: Article 113462. DOI:10.1016/j.ab.2019.113462.
Adenosine Deaminase Preparation Products And Raw materials
Raw materials
Preparation Products
Adenosine Deaminase Suppliers
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View Lastest Price from Adenosine Deaminase manufacturers
- Product
- Adenosine Deaminase 9026-93-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.0%
- Supply Ability
- 1kg/month
- Release date
- 2021-08-25
- Product
- adenosine deaminase 9026-93-1
- Price
- US $68.50-62.70/KU
- Min. Order
- 10KU
- Purity
- ≥ 10U/mg
- Supply Ability
- 1000ku
- Release date
- 2020-11-04
- Product
- EC 3.5.4.4 9026-93-1
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23