Method of Administration
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Caspofungin

Method of Administration
Product Name
Caspofungin
CAS No.
162808-62-0
Chemical Name
Caspofungin
Synonyms
Caspofungine;Caspofungin (Base);m991;CS-1171;Aids058650;Aids-058650;CASPOFUNGIN;CASPORFUNGIN;Cancidas (tm);Caspofungin MK-0991
CBNumber
CB91073222
Molecular Formula
C52H88N10O15
Formula Weight
1093.31
MOL File
162808-62-0.mol
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Caspofungin Property

Boiling point:
1408.1±65.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
pka
9.86±0.26(Predicted)
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Safety

Hazardous Substances Data
162808-62-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0005684
Product name
CASPOFUNGIN
Purity
95.00%
Packaging
5MG
Price
$495.06
Updated
2021/12/16
Chemenu
Product number
CM197348
Product name
Caspofungine
Purity
97%
Packaging
1g
Price
$729
Updated
2021/12/16
Crysdot
Product number
CD11242993
Product name
Caspofungine
Purity
97%
Packaging
1g
Price
$735
Updated
2021/12/16
AvaChem
Product number
3117B
Product name
Caspofungin
Packaging
1g
Price
$1390
Updated
2021/12/16
AvaChem
Product number
3117B
Product name
Caspofungin
Packaging
5mg
Price
$45
Updated
2021/12/16
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Caspofungin Chemical Properties,Usage,Production

Method of Administration

After reconstitution and dilution, the solution should be administered by slow intravenous infusion over approximately 1 hour.  Both 70 mg and 50 mg vials are available.   Caspofungin should be given as a single daily infusion.

Uses

Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat Aspergillus and Candida infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a potential for resistance development to occur, however in vitro resistance development to Caspofungin by Aspergillus species has not been studied.

Definition

ChEBI: A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.

Antimicrobial activity

It is active against Aspergillus spp., Candida spp. and the cyst form of Pn. jirovecii.

Acquired resistance

This is rare, but resistant strains of C. albicans, C. glabrata and C. parapsilosis have been recovered from patients failing caspofungin treatment. These strains are typically cross-resistant to other echinocandins.

Pharmaceutical Applications

A semisynthetic lipopeptide derived from a fermentation product of Glarea lozoyensis. Formulated as the diacetate for intravenous infusion.

Mechanism of action

Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.

Pharmacokinetics

Cmax 70 mg 1-h infusion: c. 10 mg/L 1 h post infusion
Plasma half-life: 9–11 h
Volume of distribution: 0.15 L/kg
Plasma protein binding: 97%
Blood concentrations increase in proportion to dosage.
Distribution
The drug is widely distributed, the highest concentrations being found in the liver. Levels in the CSF are negligible.
Metabolism and excretion
It is slowly metabolized by the liver through non-enzymatic peptide hydrolysis and N-acetylation, and the two inactive metabolites are excreted in the feces and bile. No dosage adjustment is required in patients with renal impairment; however, a dose reduction to 35 mg following the 70 mg loading dose is recommended for patients with moderate hepatic impairment. Caspofungin is not cleared by hemodialysis.

Clinical Use

Candidemia and certain invasive forms of candidosis
Esophageal candidosis
Invasive aspergillosis unresponsive to other antifungal drugs
Empirical treatment of presumed fungal infections in febrile neutropenic patients

Side effects

Occasional histamine-mediated infusion-related reactions, injection site reactions and transient abnormalities of liver enzymes have been reported. Rare cases of significant hepatic dysfunction, hepatitis or worsening liver failure have also been described.

Drug interactions

Potentially hazardous interactions with other drugs
Ciclosporin: monitor liver enzymes as transient increases in ALT and AST have been reported with concomitant administration. Avoid coadministration if possible. Increases AUC of caspofungin by 35%.
Tacrolimus: reduces tacrolimus trough concentration by 26%.

Metabolism

Plasma concentrations of caspofungin decline in a polyphasic manner after intravenous infusion. The initial short α-phase occurs immediately post-infusion and is followed by a β-phase with a half-life of 9-11 hours; an additional longer γ-phase also occurs with a half-life of 40-50 hours. Plasma clearance is dependent on distribution rather than on biotransformation or excretion. Caspofungin undergoes spontaneous degradation to an open ring compound. There is further slow metabolism of caspofungin by hydrolysis and N-acetylation and excretion in faeces and urine

Caspofungin Preparation Products And Raw materials

Raw materials

Preparation Products

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Caspofungin Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
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View Lastest Price from Caspofungin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Caspofungin 162808-62-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-11-02
Hangzhou Hyper Chemicals Limited
Product
Caspofungin 162808-62-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500KG
Release date
2024-07-05
Shaanxi Dideu Medichem Co. Ltd
Product
Caspofungin 162808-62-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25

162808-62-0, CaspofunginRelated Search:


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