Caspofungin acetate
- Product Name
- Caspofungin acetate
- CAS No.
- 179463-17-3
- Chemical Name
- Caspofungin acetate
- Synonyms
- Cancidas;Caspofungin Diacetate;(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate;Mk0991;Mk 0991;L 743872;L-743872;L 743873;L 743,872;L-743,872
- CBNumber
- CB51120146
- Molecular Formula
- C54H92N10O17
- Formula Weight
- 1153.38
- MOL File
- 179463-17-3.mol
Caspofungin acetate Property
- Melting point:
- >105°C (dec.)
- storage temp.
- -20°C
- solubility
- H2O: soluble15mg/mL (clear solution)
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 15mg/mL (clear solution)
- InChIKey
- OGUJBRYAAJYXQP-LLXMLGLCSA-N
Safety
- WGK Germany
- 3
- RTECS
- TP8046500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0425
- Product name
- Caspofungin diacetate
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $115
- Updated
- 2025/07/31
- Product number
- SML0425
- Product name
- Caspofungin diacetate
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $464
- Updated
- 2025/07/31
- Product number
- 15923
- Product name
- Caspofungin (acetate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15923
- Product name
- Caspofungin (acetate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 15923
- Product name
- Caspofungin (acetate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
Caspofungin acetate Chemical Properties,Usage,Production
Description
Caspofungin is the first in a new class of antifungal agents named echinocandin to be launched in the US for the parenteral treatment of invasive aspergillosis in patients refractory to, or intolerant of other antifungal therapies such as amphotericin-B1 lipid formulation of amphotericin-B and/or itraconazole. Caspofungin is a water soluble, stable, aza-substituted semisynthetic derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. Since fungi and humans are both eukaryotes, new antifungal agents must focus on fungus-specific targets in order to minimize potential toxicity in the human host. In this respect, the lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin has activity in vitro and in vivo against a range of Candida species (including azole and amphotericin B resistant Candida) and also against Aspergillus, an important pathogen which is not susceptible to fluconazole. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species. Cryptococcus is not susceptible to caspofungin. Caspofungin has a half-life in human beings around 10 hours. Unlike the azoles, caspofungin does not inhibit cytochrome P450. The drug has been given intravenously with loading dose of 70 rag, followed by 50 mg daily to be effective in invasive aspergillosis refractory to prior antifungal therapy. Most of the side effects were mild and comprised fever, thrombophlebitis, headache, nausea, rash and flushing.
Description
Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-
Chemical Properties
White Solid
Originator
Merck & Co (US)
Uses
Calcium antagonist, coronary vasodilator, anti-inflammatory, analgesic
Uses
Caspofungin acetate is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.
Uses
Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.
Definition
ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.
brand name
Cancidas (Merck).
Biochem/physiol Actions
Caspofungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthase, which is required for cell wall synthesis, thereby disturbing the integrity of the fungal cell wall.
Veterinary Drugs and Treatments
Caspofungin has potential for treating invasive aspergillosis or disseminated candidal infections in companion animals although little, if any, information on its use in dogs or cats is available.
References
[1] VALéRIE LETSCHER-BRU Raoul H. Caspofungin: the first representative of a new antifungal class.[J]. Journal of Antimicrobial Chemotherapy, 2003, 51 3: 513-521. DOI: 10.1093/jac/dkg117
[2] M A PFALLER. In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolates.[J]. Antimicrobial Agents and Chemotherapy, 2003, 47 3: 1068-1071. DOI: 10.1128/aac.47.3.1068-1071.2003
[3] S. PEREA. In Vitro Interaction of Caspofungin Acetate with Voriconazole against Clinical Isolates of Aspergillus spp[J]. Antimicrobial Agents and Chemotherapy, 2002, 46 1: 3039-3041. DOI: 10.1128/aac.46.9.3039-3041.2002
[4] H. LEATHER J W. Caspofungin[J]. Drugs, 2012, 61 1: 1130-1131. DOI: 10.2165/00003495-200161080-00009
[5] G K ABRUZZO. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.[J]. Antimicrobial Agents and Chemotherapy, 1997, 41 11: 2333-2338. DOI: 10.1128/aac.41.11.2333
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View Lastest Price from Caspofungin acetate manufacturers
- Product
- Caspofungin acetate 179463-17-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-21
- Product
- Caspofungin acetate 179463-17-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- Caspofungin acetate 179463-17-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24