ChemicalBook > CAS DataBase List > 1-BENZOFURAN-5-AMINE

1-BENZOFURAN-5-AMINE

Product Name
1-BENZOFURAN-5-AMINE
CAS No.
58546-89-7
Chemical Name
1-BENZOFURAN-5-AMINE
Synonyms
Benzofuran-5-aMine;5-BenzofuranaMine;5-amino Benzofuran;1-BENZOFURAN-5-AMINE;5-Aminobenzo[b]furan;5-Amino-1-benzofuran;Vilazodone Impurity 11;5-Aminobenzo[b]furan97%;5-Aminobenzo[b]furan 97%;5-Amino-1-benzofuran 97%
CBNumber
CB2697312
Molecular Formula
C8H7NO
Formula Weight
133.15
MOL File
58546-89-7.mol
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1-BENZOFURAN-5-AMINE Property

Boiling point:
259.8±13.0 °C(Predicted)
Density 
1.225±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.87±0.10(Predicted)
form 
liquid
color 
Orange
InChI
InChI=1S/C8H7NO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5H,9H2
InChIKey
GMOLCSICTCPZCU-UHFFFAOYSA-N
SMILES
O1C2=CC=C(N)C=C2C=C1
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Safety

Hazard Note 
Harmful
HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B203625
Product name
5-Benzofuranamine
Packaging
100mg
Price
$345
Updated
2021/12/16
Apolloscientific
Product number
OR9276
Product name
5-Aminobenzo[b]furan
Purity
97%
Packaging
5g
Price
$638
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0017719
Product name
1-BENZOFURAN-5-AMINE
Purity
95.00%
Packaging
250MG
Price
$679.37
Updated
2021/12/16
SynQuest Laboratories
Product number
4H30-1-V3
Product name
5-Aminobenzo[b]furan
Purity
97%
Packaging
5G
Price
$704
Updated
2021/12/16
AK Scientific
Product number
Y9550
Product name
1-Benzofuran-5-amine
Packaging
5g
Price
$813
Updated
2021/12/16
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1-BENZOFURAN-5-AMINE Chemical Properties,Usage,Production

Uses

5-Benzofuranamine acts as a reagent in the synthesis of substituted pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

Definition

ChEBI: 1-Benzofuran-5-amine is a member of benzofurans.

Synthesis

18761-31-4

7439-89-6

58546-89-7

Step 1. 5-Nitrobenzofuran (Compound 104, 1.89 g, 11.63 mmol), iron powder (6.5 g, 116 mmol), 36.5% hydrochloric acid (1 mL), ethanol (30 mL), and water (6 mL) were mixed, stirred, and heated to 100 °C, and the reaction was maintained for 3 hours. After completion of the reaction, the precipitate was filtered and washed with ethanol. The filtrates were combined and the solvent was removed by evaporation to give a residue. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed sequentially with aqueous sodium bicarbonate (20 mL x 2) and brine (20 mL x 1), dried over magnesium sulfate, filtered and the solvent was evaporated to afford 1-benzofuran-5-amine (Compound 105) as a brown solid (0.8 g, 51% yield).LC-MS: 134 [M + 1]+; 1H NMR ( DMSO-d6): δ 4.8 (s, 2H), 6.57 (m, 1H), 6.67 (m, 1H), 6.69 (m, 1H), 7.21 (d, J = 9.3 Hz, 1H), 7.74 (d, J = 2.4 Hz, 1H).

References

[1] Patent: US2009/76044, 2009, A1. Location in patent: Page/Page column 25

1-BENZOFURAN-5-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZOFURAN-5-AMINE Suppliers

Belgium 1 China 63 India 4 United Kingdom 2 United States 12 Global 82
Block Chemical Technology (Shanghai) Co., Ltd.
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021-20432219 13918097649
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QQ79021576
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li_jinfei@acblock-lab.com
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China
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Shanghai Sainty Biotechnology Co., Ltd.
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021-58957915 17721108391
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QQ: 907522080
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907522080@qq.com
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China
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996
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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China
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Hefei Shenghang Pharmaceutical Technology Co., Ltd.
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18326946292
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2816071490@QQ.COM
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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jkinfo@jkchemical.com
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Energy Chemical
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BOC Sciences
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T&W GROUP
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021-61551611 13296011611
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＋86 21-50676805
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contact@trustwe.com
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China
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Hangzhou Sage Chemical Co., Ltd.
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+86057186818502 13588463833
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Pls mail us for more information!
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info@sagechem.com
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China
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10266
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Thermo Fisher Scientific
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800-810-5118
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+86-10-84193589
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cnchemical@thermofisher.com
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China
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58546-89-7, 1-BENZOFURAN-5-AMINERelated Search:

VILAZODONE 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)- 3-(4-Chloro-1-hydroxybutyl)-1H-indole-5-carbonitrile ISO-PROPYLCHLOROBUTYRATE 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid Vilazodone Impurity 24 Vilazodone Impurity 30 Vilazodone Impurity 4 Vilazodone Impurity 21 Vilazodone Impurity 26 Vilazodone Impurity 13 Vilazodone Impurity 18 Vilazodone Impurity 34 Vilazodone Impurity 8 Vilazodone Impurity 25 Vilazodone Impurity 31 Vilazodone Impurity 5 Vilazodone Impurity 22

  • 5-Amino-1-benzofuran
  • 5-Amino-1-benzofuran 97%
  • 5-Aminobenzo[b]furan
  • 1-BENZOFURAN-5-AMINE
  • 5-Aminobenzo[b]furan 97%
  • 1-Benzofuran-5-amine, Benzo[b]furan-5-amine
  • Vilazodone Impurity 11
  • 5-amino Benzofuran
  • 5-BenzofuranaMine
  • Benzofuran-5-aMine
  • 5-Aminobenzo[b]furan97%
  • Vilazodone Impurity 11 (5-Amino Benzofuran)
  • Vilazidone amino benzofuron
  • 58546-89-7