1-BENZOFURAN-5-AMINE
- Product Name
- 1-BENZOFURAN-5-AMINE
- CAS No.
- 58546-89-7
- Chemical Name
- 1-BENZOFURAN-5-AMINE
- Synonyms
- Benzofuran-5-aMine;5-BenzofuranaMine;5-amino Benzofuran;1-BENZOFURAN-5-AMINE;5-Aminobenzo[b]furan;5-Amino-1-benzofuran;Vilazodone Impurity 11;5-Aminobenzo[b]furan97%;5-Aminobenzo[b]furan 97%;5-Amino-1-benzofuran 97%
- CBNumber
- CB2697312
- Molecular Formula
- C8H7NO
- Formula Weight
- 133.15
- MOL File
- 58546-89-7.mol
1-BENZOFURAN-5-AMINE Property
- Boiling point:
- 259.8±13.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.87±0.10(Predicted)
- form
- liquid
- color
- Orange
- InChI
- InChI=1S/C8H7NO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5H,9H2
- InChIKey
- GMOLCSICTCPZCU-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(N)C=C2C=C1
Safety
- Hazard Note
- Harmful
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B203625
- Product name
- 5-Benzofuranamine
- Packaging
- 100mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- OR9276
- Product name
- 5-Aminobenzo[b]furan
- Purity
- 97%
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 4H30-1-V3
- Product name
- 5-Aminobenzo[b]furan
- Purity
- 97%
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- OR9276
- Product name
- 5-Aminobenzo[b]furan
- Purity
- 97%
- Packaging
- 1g
- Price
- $177
- Updated
- 2021/12/16
- Product number
- 4H30-1-V3
- Product name
- 5-Aminobenzo[b]furan
- Purity
- 97%
- Packaging
- 1g
- Price
- $196
- Updated
- 2021/12/16
1-BENZOFURAN-5-AMINE Chemical Properties,Usage,Production
Uses
5-Benzofuranamine acts as a reagent in the synthesis of substituted pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Definition
ChEBI: 1-Benzofuran-5-amine is a member of benzofurans.
Synthesis
18761-31-4
7439-89-6
58546-89-7
Step 1. 5-Nitrobenzofuran (Compound 104, 1.89 g, 11.63 mmol), iron powder (6.5 g, 116 mmol), 36.5% hydrochloric acid (1 mL), ethanol (30 mL), and water (6 mL) were mixed, stirred, and heated to 100 °C, and the reaction was maintained for 3 hours. After completion of the reaction, the precipitate was filtered and washed with ethanol. The filtrates were combined and the solvent was removed by evaporation to give a residue. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed sequentially with aqueous sodium bicarbonate (20 mL x 2) and brine (20 mL x 1), dried over magnesium sulfate, filtered and the solvent was evaporated to afford 1-benzofuran-5-amine (Compound 105) as a brown solid (0.8 g, 51% yield).LC-MS: 134 [M + 1]+; 1H NMR ( DMSO-d6): δ 4.8 (s, 2H), 6.57 (m, 1H), 6.67 (m, 1H), 6.69 (m, 1H), 7.21 (d, J = 9.3 Hz, 1H), 7.74 (d, J = 2.4 Hz, 1H).
References
[1] Patent: US2009/76044, 2009, A1. Location in patent: Page/Page column 25
1-BENZOFURAN-5-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-BENZOFURAN-5-AMINE Suppliers
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