VILAZODONE
Description References- Product Name
- VILAZODONE
- CAS No.
- 163521-12-8
- Chemical Name
- VILAZODONE
- Synonyms
- CS-108;AK-Con;All Clear;Vilozodone;VILAZODONE;EMD 515259;Clear Eyes;Velazolone;Vilazodonei;Vilazodone-d6
- CBNumber
- CB31011682
- Molecular Formula
- C26H27N5O2
- Formula Weight
- 441.52
- MOL File
- 163521-12-8.mol
VILAZODONE Property
- Melting point:
- 203-205°C
- Boiling point:
- 745.1±60.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly)), Methanol (Slightly)
- pka
- 15.98±0.30(Predicted)
- form
- Solid
- color
- Pale Yellow to Beige
- Stability:
- Very Hygroscopic
- InChI
- InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
- InChIKey
- SGEGOXDYSFKCPT-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(N3CCN(CCCCC4C5=C(NC=4)C=CC(C#N)=C5)CC3)C=C2C=C1C(N)=O
- CAS DataBase Reference
- 163521-12-8
Safety
- Hazardous Substances Data
- 163521-12-8(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- V265000
- Product name
- Vilazodone
- Packaging
- 250mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- CS-0550
- Product name
- Vilazodone
- Purity
- 99.91%
- Packaging
- 50mg
- Price
- $396
- Updated
- 2021/12/16
- Product number
- D34392
- Product name
- Vilazodone-d8HCl
- Packaging
- 1mg
- Price
- $675
- Updated
- 2021/12/16
- Product number
- 094760
- Product name
- 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $681
- Updated
- 2021/12/16
- Product number
- API0008118
- Product name
- VILAZODONE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $697.2
- Updated
- 2021/12/16
VILAZODONE Chemical Properties,Usage,Production
Description
Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo.
References
https://www.drugbank.ca/drugs/DB06684
https://en.wikipedia.org/wiki/Vilazodone
http://www.rxlist.com/viibryd-drug/indications-dosage.htm
Description
In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC50=0.2 nM) with high affinity for 5-HT1A receptors (IC50=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.
Chemical Properties
Light Yellow Solid
Originator
Merck KGaA (Germany)
Uses
It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
Uses
Labelled analogue of Vilazodone
Uses
An inhibitor of ST and activator of SR-1A
Definition
ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.
brand name
Viibryd
Mechanism of action
The mechanism of action of Vilazodone antidepressant is to enhance the release of serotonin from the serotonergic pathway in the brain by inhibiting the serotonin transporter (similar to a selective serotonin reuptake inhibitor (SSRI)) while stimulating the serotonin-1a receptor through partial agonism. Its agonistic effects are similar to those of the anxiolytic drug buspirone.
Side effects
The most common side effects of Vilazodone administered orally include: diarrhoea, dizziness, headache, dry mouth, nausea, vomiting, and sleep disturbances. These symptoms are mild and may disappear within a few days or weeks. Other serious side effects that may occur include: bleeding, hyponatraemia (low levels of sodium in the blood, manifested by dizziness, light-headedness, difficulty concentrating and fainting), mania, seizures (loss of consciousness, twitching of limbs), closed-angle glaucoma (sudden eye pain or loss of vision) and allergic reactions. Seek medical attention if any of these serious adverse symptoms occur.
VILAZODONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from VILAZODONE manufacturers
- Product
- Vilazodone Impurity 163521-12-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98
- Supply Ability
- 10000000
- Release date
- 2025-02-21
- Product
- VILAZODONE 163521-12-8
- Price
- US $1.00/kg
- Min. Order
- 0.1kg
- Purity
- 99
- Supply Ability
- 20
- Release date
- 2024-08-01
- Product
- Vilazodone 163521-12-8
- Price
- US $48.00-40.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2tons
- Release date
- 2021-06-17