ChemicalBook > CAS DataBase List > 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL

1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL

Product Name
1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
CAS No.
75144-12-6
Chemical Name
1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
Synonyms
Antitrypanosomal agent 1;1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one;1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL;1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride;1-Propanone1-(34-dichlorophenyl)-3-(dimethylamino)-hydrochloride;1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride;Antitrypanosomal agent-1,Antitrypanosomal agent 1,T.brucei,trypanothione,inhibit,glutathione,Antitrypanosomal agent1,Inhibitor,reductase,Parasite,anti-trypanosomal
CBNumber
CB11519588
Molecular Formula
C11H14Cl3NO
Formula Weight
282.59
MOL File
75144-12-6.mol
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1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Property

Melting point:
186 - 188°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White
Water Solubility 
Water: 10 mg/mL (35.39 mM)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D435873
Product name
1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanoneHydrochloride
Packaging
50mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-0045380
Product name
Antitrypanosomalagent1
Packaging
1g
Price
$85
Updated
2021/12/16
AK Scientific
Product number
1400AL
Product name
1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanoneHCl
Packaging
1g
Price
$151
Updated
2021/12/16
ChemScene
Product number
CS-0045380
Product name
Antitrypanosomalagent1
Packaging
5g
Price
$276
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0063405
Product name
1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$713.1
Updated
2021/12/16
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1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Chemical Properties,Usage,Production

Biological Activity

Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity.

in vitro

Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20.

target

IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)
EC50: 1 μM ( T. brucei )

1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Suppliers

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75144-12-6, 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCLRelated Search:

1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE 3',4'-DICHLOROPROPIOPHENONE 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL

  • 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
  • 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride
  • 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride
  • Antitrypanosomal agent 1
  • 1-Propanone1-(34-dichlorophenyl)-3-(dimethylamino)-hydrochloride
  • 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one
  • Antitrypanosomal agent-1,Antitrypanosomal agent 1,T.brucei,trypanothione,inhibit,glutathione,Antitrypanosomal agent1,Inhibitor,reductase,Parasite,anti-trypanosomal
  • 75144-12-6