5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- Product Name
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- CAS No.
- 253870-02-9
- Chemical Name
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- Synonyms
- 5-Formyl-2,4-dimethylpyrrole-3-carboxylic acid;5-Formyl-2;-2,4-dimethyL;Sunitinib Impurity 27;Sunitinib interMediate;5-ForMyl-2,4-diMethyl-1H-;4-dimethyl-1H-pyrrole-3-carboxylic acid;5-Formyl-2-4-dimethylpyrole-2-carboxylic Acid;3,5-DIMETHYL-2-FORMYLPYRROLE-4-CARBOXYLIC ACID;5-Formyl-2,4-dimethyl-3-pyrrolecarboxylic Acid
- CBNumber
- CB1156124
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 253870-02-9.mol
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Property
- Melting point:
- 283°C(lit.)
- Boiling point:
- 374.9±42.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 5.56±0.50(Predicted)
- form
- Solid
- color
- Beige
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C8H9NO3/c1-4-6(3-10)9-5(2)7(4)8(11)12/h3,9H,1-2H3,(H,11,12)
- InChIKey
- YCIHQDVIAISDPS-UHFFFAOYSA-N
- SMILES
- N1C(C=O)=C(C)C(C(O)=O)=C1C
- CAS DataBase Reference
- 253870-02-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0939
- Product name
- 5-Formyl-2,4-dimethyl-3-pyrrolecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- F0939
- Product name
- 5-Formyl-2,4-dimethyl-3-pyrrolecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- F700253
- Product name
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylicAcid
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 074154
- Product name
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 10g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- L072
- Product name
- 2,4-Dimethyl-5-formylpyrrole-3-carboxylicacid
- Packaging
- 25g
- Price
- $193
- Updated
- 2021/12/16
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Chemical Properties,Usage,Production
Description
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is an important organic intermediate to synthetize substituted pyrrole products.
Uses
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid is useful for the synthesis of 5-Bromo-7-azaindolin-2-one derivatives which possesses in vitro activity against selected cancer cell lines.
Uses
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is a yellow crystalline substance, mainly used as pharmaceutical intermediates.
Application
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid can be used to prepare a drug carrier (cRGD-PEG-N＝CH-R6-Por (cPRP) triblock copolymer) for achieving highly efficient synergistic combined chemotherapy-photodynamic cancer therapy.
Synthesis
2199-59-9
253870-02-9
Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (19.4 g, 100 mmol) was used as a raw material and dissolved in a solvent mixture of methanol (100 mL) and water (400 mL). A 5N KOH solution (200 mL) was slowly added under stirring conditions. The reaction mixture was heated to reflux and stirred continuously for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with 5N HCl solution to 3. Subsequently, the precipitate was collected by filtration and washed with distilled water. Finally, the resulting solid was dried under vacuum to afford the target product 2,4-dimethyl-5-formyl-1H-pyrrole-3-carboxylic acid (15.5 g, 94% yield) as a yellow-brown solid.
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 248 - 262
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 139 - 146
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3062 - 3065
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 14, p. 2782 - 2787
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 7, p. 1116 - 1119
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid manufacturers
- Product
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 253870-02-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-10
- Product
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 253870-02-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2021-11-20
- Product
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 253870-02-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29