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(R)-N-BOC-2-methylproline

Product Name
(R)-N-BOC-2-methylproline
CAS No.
166170-15-6
Chemical Name
(R)-N-BOC-2-methylproline
Synonyms
(R)-1-(tert-Butoxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid;EOS-61195;Boc-α-Me-D-Pro-OH;Boc-a-Me-D-Pro-OH;Boc-alpha-Me-D-Pro-OH;1-Boc-2-Methyl-D-proline;N-Boc-2-methyl-D-proline;(R)-N-BOC-2-methylproline;(R)-N-BOC-Α-METHYLPROLINE;(R)-N-Boc-a-Methylproline
CBNumber
CB11563617
Molecular Formula
C11H19NO4
Formula Weight
229.27
MOL File
166170-15-6.mol
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(R)-N-BOC-2-methylproline Property

Melting point:
127-129℃
Boiling point:
337.8±35.0 °C(Predicted)
Density 
1.160
storage temp. 
2-8°C
pka
4.20±0.20(Predicted)
Appearance
Off-white to brown Solid
InChI
InChI=1S/C11H19NO4/c1-10(2,3)16-9(15)12-7-5-6-11(12,4)8(13)14/h5-7H2,1-4H3,(H,13,14)/t11-/m1/s1
InChIKey
YQXRKJHVAUKXRN-LLVKDONJSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@]1(C)C(O)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T135698
Product name
(R)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicAcid
Packaging
50mg
Price
$60
Updated
2021/12/16
ChemPep
Product number
181676
Product name
Boc-α-Me-D-Pro-OH
Packaging
1g
Price
$726
Updated
2021/12/16
Activate Scientific
Product number
AS55360-2R
Product name
(R)-1-(Boc)-2-Methylpyrrolidine-2-carboxylic acid
Purity
97+% ee
Packaging
100g
Price
$746
Updated
2021/12/16
ChemPep
Product number
181676
Product name
Boc-α-Me-D-Pro-OH
Packaging
5g
Price
$1778
Updated
2021/12/16
Activate Scientific
Product number
AS55360-2R
Product name
(R)-1-(Boc)-2-Methylpyrrolidine-2-carboxylic acid
Purity
97+% ee
Packaging
1g
Price
$34
Updated
2021/12/16
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(R)-N-BOC-2-methylproline Chemical Properties,Usage,Production

Synthesis

912445-03-5

166170-15-6

General procedure for the synthesis of (R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid from the compound (CAS: 912445-03-5): Step 74D: Synthesis of (R)-2-methylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester A 5% palladium-carbon catalyst (2.56 g) was added to the pressure reactor and the reactor was purged with nitrogen. The Example 74C product (α60wt% isopropyl acetate solution, 83.1 g) and denatured ethanol (335 g) were then added. The reactor was pressurized with hydrogen (40 psig) and the hydrogenolysis reaction was carried out while controlling the reaction temperature to not exceed 40°C. Upon completion of the reaction, the catalyst was removed by filtration to give a product with a measured yield of 97% and an enantiomeric excess (ee) of 93.9%. Post-treatment step: the solvent was removed by distillation under vacuum and solvent replacement was carried out with isopropyl acetate (240 g). This was followed by the addition of heptane (200 g) for further replacement, then additional heptane (500 g) was added and the mixture was heated to reflux until all solids were completely dissolved. After cooling the solution to 20°C, the solid product was collected by filtration, washed with heptane (80 g) and dried to give 54.8 g of Example 74D product in 88% yield. Product characterization: 1H NMR (400 MHz, CDCl3, rotary isomer mixture) δ ppm 1.42 (s) and 1.47 (s), (9H); 1.52 (s) and 1.61 (s) (2H); 1.73-2.05 (m, 3H); 2.19-2.38 (m) and 2.46-2.67 (m) (1H); 3.26- 3.71 (m, 2H).

References

[1] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 29-30

(R)-N-BOC-2-methylproline Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-BOC-2-methylproline Suppliers

China 114 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 8 Global 126
IRIS Biotech GmbH
Tel
--
Fax
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Country
Germany
ProdList
4426
Advantage
68
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View Lastest Price from (R)-N-BOC-2-methylproline manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(R)-N-BOC-2-methylproline 166170-15-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Henan Fengda Chemical Co., Ltd
Product
(R)-N-BOC-2-methylproline 166170-15-6
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Career Henan Chemical Co
Product
(R)-N-BOC-2-methylproline 166170-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-07-03

166170-15-6, (R)-N-BOC-2-methylprolineRelated Search:

(2R)-1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid (R)-1-(Benzyloxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid (R)-1-(tert-butoxycarbonyl)-2-(hydroxymethyl)pyrrolidine-2-carboxylic acid α-Me-D-Phe(3-NO<sub>2<sub>)-OH·H<sub>2<sub>O (S)-2-Methylproline α-Me-Phe(2-NO<sub>2<sub>)-OH·H<sub>2<sub>O α-Me-Phe(3-NO<sub>2<sub>)-OH·H<sub>2<sub>O α-Me-Phe(4-Ph)-OH·H<sub>2<sub>O N-BOC-ALPHA-METHYL-L-PROLINE α-Me-D-Phe(2-NO<sub>2<sub>)-OH·H<sub>2<sub>O H-ALPHA-ME-D-PRO-OH Nε-acryloyl-L-lysin 2-Methyl-L-proline Methyl ester hydrochloride L-PHE(4-COCH3) dimethylleucine L-Leucine, N,N-dimethyl- (+/-)-1-AMINOCYCLOPENTANE-CIS-1,2-DICARBOXYLIC ACID CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester

  • (R)-N-BOC-2-methylproline
  • 1-(tert-butoxycarbonyl)-2-methyl-D-proline(SALTDATA: FREE)
  • 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) ester, (2R)-
  • (2R)-2-Methyl-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
  • 1-Boc-2-Methyl-D-proline
  • (R)-1-Boc-2-Methyl-proline
  • (R)-N-BOC-Α-METHYLPROLINE
  • Boc-α-Me-D-Pro-OH
  • (R)-1-(tert-Butoxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid
  • (2R)-1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-2-carboxylic acid
  • Boc-alpha-Me-D-Pro-OH
  • (R)-N-BOC-alpha-METHYLPROLINE
  • (2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
  • EOS-61195
  • (Tert-Butoxy)Carbonyl Alpha-Methyl-D-Pro-OH
  • Boc-a-Me-D-Pro-OH
  • N-Boc-2-methyl-D-proline
  • (2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrroli
  • (R)-N-Boc-a-Methylproline
  • 1-(tert-butoxycarbonyl)-2-methyl-D-proline
  • 166170-15-6
  • α-Methyl Amino Acids