ChemicalBook > CAS DataBase List > N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

Product Name
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
CAS No.
916603-07-1
Chemical Name
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
Synonyms
CZC-8004;CZC 00008004;DianilinopyriMidine_01;Dianilinopyrimidine_01(CZC8004);N-(4-broMophenyl)-N-(naphthalen-2-yl);N-(4-broMophenyl)-N-(naphthalen-2-yl) naphthalen-1-aMine;Target-5 (Kinase Probe Tool, APM-1)/Dianilinopyrimidine_01;N2-(4-(aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-...;N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine;N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-pyrimidinediamine
CBNumber
CB11565156
Molecular Formula
C17H16FN5
Formula Weight
309.34
MOL File
916603-07-1.mol
More
Less

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine Property

Boiling point:
514.1±60.0 °C(Predicted)
Density 
1.332
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming)
pka
9.14±0.10(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
16718
Product name
CZC-8004
Purity
≥98%
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
16718
Product name
CZC-8004
Purity
≥98%
Packaging
1mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
16718
Product name
CZC-8004
Purity
≥98%
Packaging
5mg
Price
$396
Updated
2024/03/01
Cayman Chemical
Product number
16718
Product name
CZC-8004
Purity
≥98%
Packaging
10mg
Price
$632
Updated
2024/03/01
TRC
Product number
A617370
Product name
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
Packaging
10mg
Price
$500
Updated
2021/12/16
More
Less

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine Chemical Properties,Usage,Production

Description

CZC-8004 (916603-07-1) is a pan-specific kinase inhibitor. May be coupled to sepharose via its amino-side chain for affinity chromatography applications1.

Uses

A novel enzyme-interacting compounds using immobilized broad-spectrum ligands

Uses

CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.

Definition

ChEBI: CZC8004 is an aminopyrimidine and an organofluorine compound. It has a role as a protein kinase inhibitor.

References

1) Klutchko?et al. (1998),?2-Substituted aminopyrido[2,3-d]pyrilidin-7(8H)-ones, structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity; J. Med. Chem.,?41?3276

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine Suppliers

Canada 1 China 56 India 1 United Kingdom 2 United States 14 Global 74
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
More
Less

View Lastest Price from N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine manufacturers

Career Henan Chemical Co
Product
CZC8004 916603-07-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-02-05

916603-07-1, N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamineRelated Search:

AG 490 CYCLOPAMINE (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Geldanamycin Sulfanilic acid p-Toluidine

  • DianilinopyriMidine_01
  • CZC 00008004
  • N-(4-broMophenyl)-N-(naphthalen-2-yl)
  • N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-pyrimidinediamine
  • N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
  • N-(4-broMophenyl)-N-(naphthalen-2-yl) naphthalen-1-aMine
  • CZC-8004
  • Target-5 (Kinase Probe Tool, APM-1)/Dianilinopyrimidine_01
  • 2,4-Pyrimidinediamine, N2-[4-(aminomethyl)phenyl]-5-fluoro-N4-phenyl-
  • N2-(4-(aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-...
  • CZC 8004,HER1,Vascular endothelial growth factor receptor,ErbB-1,Epidermal growth factor receptor,CZC-8004,CZC8004,aminopyrimidine,Inhibitor,tyrosine kinases,CZC 00008004,EGFR,CZC00008004,inhibit,VEGFR
  • Dianilinopyrimidine_01(CZC8004)
  • 2-n-[4-(aminomethyl)phenyl]-5-fluoro-4-n-phenylpyrimidine-2,4-diamine
  • 916603-07-1
  • C17H16FN5
  • Chemical Amines
  • Amines
  • Aromatics
  • Heterocycles