4-Isobutyl-2-pyrrolidinone
- Product Name
- 4-Isobutyl-2-pyrrolidinone
- CAS No.
- 61312-87-6
- Chemical Name
- 4-Isobutyl-2-pyrrolidinone
- Synonyms
- Pregabalin Lactam;4-isobutylpyrrolidin-2-one;Pregaballin Lactam;4-(2-Methylpropyl)-;Pregabalin USP RC A;Pregabalin USP RC C;Pregabalin impurity D;Pregabalin IMpurity IV;(RS)-Pregabalin Lactam);4-isobutyl-2-pyrrolidone
- CBNumber
- CB11565237
- Molecular Formula
- C8H15NO
- Formula Weight
- 141.21
- MOL File
- 61312-87-6.mol
4-Isobutyl-2-pyrrolidinone Property
- Boiling point:
- 269.1±9.0 °C(Predicted)
- Density
- 0.927±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 16.66±0.40(Predicted)
- color
- Colourless to Light Yellow Oil
- Major Application
- pharmaceutical
- InChI
- 1S/C8H15NO/c1-6(2)3-7-4-8(10)9-5-7/h6-7H,3-5H2,1-2H3,(H,9,10)
- InChIKey
- GUGXRXLTTHFKHC-UHFFFAOYSA-N
- SMILES
- N1CC(CC1=O)CC(C)C
- CAS DataBase Reference
- 61312-87-6
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933790002
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I786500
- Product name
- 4-Isobutyl-2-pyrrolidinone(pregabalinlactamimpurity)
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- I786500
- Product name
- 4-Isobutyl-2-pyrrolidinone(pregabalinlactamimpurity)
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- II24661
- Product name
- 4-Isobutyl-2-pyrrolidinone
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- II24661
- Product name
- 4-Isobutyl-2-pyrrolidinone
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- II24661
- Product name
- 4-Isobutyl-2-pyrrolidinone
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
4-Isobutyl-2-pyrrolidinone Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Oil
Uses
Impurity in commercial preparation of Pregabalin.
Uses
Pregabalin (P704800)
Uses
Pregabalin intermediate
Synthesis
To 600 mL of methanol, 50.00 g of nitro compound (01), 18.04 g of NiCl2-6H2O was added; the solution was cooled down to 0??C-5??C and 18.2 g of sodium borohydride was added. After addition, the temperature was raised to 40??C-45??C and stirred for 12 hours. Then the mixture was cooled down to room temperature, drops of aqueous hydrochloric acid solution, adjust the pH = 2-3. The reaction solution was concentrated under reduced pressure until the system was free of obvious methanol (gas chromatography detection), ethyl acetate was added for extraction, washed with water, and the organic layer was dried and concentrated to obtain the lactam compound (02) Isobutyl-2-pyrrolidinone, a light yellow oily substance of 31.20 g, yield 96.0%, purity 99.10%.
4-Isobutyl-2-pyrrolidinone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Isobutyl-2-pyrrolidinone manufacturers
- Product
- 4-Isobutyl-2-pyrrolidinone 61312-87-6
- Price
- US $660.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1T
- Release date
- 2020-07-06
- Product
- 4-Isobutyl-2-pyrrolidinone 61312-87-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-14