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H-LYS-D-PRO-THR-OH

Product Name
H-LYS-D-PRO-THR-OH
CAS No.
117027-34-6
Chemical Name
H-LYS-D-PRO-THR-OH
Synonyms
LYS-D-PRO-THR;L-LYS-D-PRO-L-THR;H-LYS-D-PRO-THR-OH;interleukin1beta(193-195;INTERLEUKIN 1B ANTAGONIST;L-LYSYL-D-PROLYL-L-THREONINE;L-Threonine, L-lysyl-D-prolyl-;(D-PRO194)-IL-1B (193-195) (HUMAN);(D-Pro194)-IL-1β (193-195) (human);(D-PRO194)-IL-1BETA (193-195) (HUMAN)
CBNumber
CB1159125
Molecular Formula
C15H28N4O5
Formula Weight
344.41
MOL File
117027-34-6.mol
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H-LYS-D-PRO-THR-OH Property

storage temp. 
−20°C
solubility 
H2O: 10 mg/mL, clear, colorless
form 
Solid
color 
White to off-white
Sequence
Lys-{d-Pro}-Thr
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
AAA0005596
Product name
L-LYSYL-D-PROLYL-L-THREONINE
Purity
95.00%
Packaging
5MG
Price
$499.77
Updated
2021/12/16
AHH
Product number
MT-16474
Product name
L-LYSYL-D-Prolyl-L-Threonine
Purity
98%
Packaging
0.1g
Price
$370
Updated
2021/12/16
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H-LYS-D-PRO-THR-OH Chemical Properties,Usage,Production

Uses

Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].

in vivo

Lys-D-Pro-Thr (10 mg/kg; IP; for 4 days) inhibits the protective effect of fMLP (HY-P0224) and that of MMK-1 (HY-P1117) against Etoposide (HY-13629)-induced alopecia[1].

Animal Model:11-d-old rats[1]
Dosage:10 mg/kg
Administration:IP; for 4 days
Result:Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.

IC 50

IL-1

References

[1] Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202. DOI:10.1271/bbb.60656
[2] Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11. DOI:10.1016/0143-4179(91)90067-s

H-LYS-D-PRO-THR-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-LYS-D-PRO-THR-OH Suppliers

China 49 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 6 Global 60
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
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86-21-61263399
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ymbetter@glbiochem.com
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China
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9981
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
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China
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42934
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
Email
shchemsky@sina.com
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China
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15402
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60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
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sales@amadischem.com
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China
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131957
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Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
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sales@njleonbiotech.com
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China
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5501
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Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
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China
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9979
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Chengdu Youngshe Chemical Co., Ltd.
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+86-17380623303
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028-62328193
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Caroline@youngshechem.com
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China
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Hubei widely chemical technology Co., Ltd.
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027-83778895 18602735115
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027-51119224
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18602735115@163.com
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China
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2005
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Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
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China
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7408
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58
Sichuan Jisheng Biopharmaceutical Co.,Ltd.
Tel
+86-0833-2598983 +86-18086877136
Fax
+86-833-2598903
Email
Nyx-peptide@jsjpharm.cn
Country
China
ProdList
308
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117027-34-6, H-LYS-D-PRO-THR-OHRelated Search:

H-D-ALA-ALA-OH GLYCYL-L-THREONINE (R)-PYRROLIDINE-2-CARBALDEHYDE H-ALA-D-ALA-ALA-OH (R)-(+)-2-AMINOMETHYL-1-ETHYLPYRROLIDINE 2,2-DIMETHYL-2,3-DIHYDRO-1-BENZOFURAN-7-CARBALDEHYDE D-Prolinamide H-LYS-D-PRO-THR-OH AC-THR-OH

  • (D-PRO194)-IL-1B (193-195) (HUMAN)
  • (D-PRO194)-IL-1BETA (193-195) (HUMAN)
  • (D-PRO194)-INTERLEUKIN-1B (193-195) (HUMAN)
  • (D-PRO194)-INTERLEUKIN-1BETA (193-195) (HUMAN)
  • H-LYS-D-PRO-THR-OH
  • INTERLEUKIN 1B ANTAGONIST
  • LYS-D-PRO-THR
  • L-LYSYL-D-PROLYL-L-THREONINE
  • L-LYS-D-PRO-L-THR
  • interleukin1beta(193-195
  • (D-Pro194)-Interleukin-1b (193-195) (huMan), LDPT
  • (D-Pro194)-Interleukin-1β (193-195) (human)
  • 2-[[[1-(2,6-diamino-1-oxohexyl)-2-pyrrolidinyl]-oxomethyl]amino]-3-hydroxybutanoic acid
  • L-Threonine, L-lysyl-D-prolyl-
  • (D-Pro194)-IL-1β (193-195) (human)
  • (2S,3R)-2-((R)-1-((S)-2,6-Diaminohexanoyl)pyrrolidine-2-carboxamido)-3-hydroxybutanoic acid
  • 117027-34-6