ChemicalBook > CAS DataBase List > H-LYS-D-PRO-THR-OH

H-LYS-D-PRO-THR-OH

Product Name: H-LYS-D-PRO-THR-OH
CAS No.: 117027-34-6
Chemical Name: H-LYS-D-PRO-THR-OH
Synonyms: LYS-D-PRO-THR;L-LYS-D-PRO-L-THR;H-LYS-D-PRO-THR-OH;interleukin1beta(193-195;INTERLEUKIN 1B ANTAGONIST;L-LYSYL-D-PROLYL-L-THREONINE;L-Threonine, L-lysyl-D-prolyl-;(D-PRO194)-IL-1B (193-195) (HUMAN);(D-Pro194)-IL-1β (193-195) (human);(D-PRO194)-IL-1BETA (193-195) (HUMAN)
CBNumber: CB1159125
Molecular Formula: C15H28N4O5
Formula Weight: 344.41
MOL File: 117027-34-6.mol

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H-LYS-D-PRO-THR-OH Property

storage temp.: −20°C
solubility: H₂O: 10 mg/mL, clear, colorless
form: Solid
color: White to off-white
Sequence: Lys-{d-Pro}-Thr

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: AAA0005596
Product name: L-LYSYL-D-PROLYL-L-THREONINE
Purity: 95.00%
Packaging: 5MG
Price: $499.77
Updated: 2021/12/16

AHH

Product number: MT-16474
Product name: L-LYSYL-D-Prolyl-L-Threonine
Purity: 98%
Packaging: 0.1g
Price: $370
Updated: 2021/12/16

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H-LYS-D-PRO-THR-OH Chemical Properties,Usage,Production

Uses

Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].

in vivo

Lys-D-Pro-Thr (10 mg/kg; IP; for 4 days) inhibits the protective effect of fMLP (HY-P0224) and that of MMK-1 (HY-P1117) against Etoposide (HY-13629)-induced alopecia^[1].

Animal Model:	11-d-old rats^[1]
Dosage:	10 mg/kg
Administration:	IP; for 4 days
Result:	Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.

IC 50

IL-1

References

[1] Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202. DOI:10.1271/bbb.60656
[2] Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11. DOI:10.1016/0143-4179(91)90067-s

H-LYS-D-PRO-THR-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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117027-34-6, H-LYS-D-PRO-THR-OHRelated Search:

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(D-PRO194)-IL-1B (193-195) (HUMAN)

(D-PRO194)-IL-1BETA (193-195) (HUMAN)

(D-PRO194)-INTERLEUKIN-1B (193-195) (HUMAN)

(D-PRO194)-INTERLEUKIN-1BETA (193-195) (HUMAN)

H-LYS-D-PRO-THR-OH

INTERLEUKIN 1B ANTAGONIST

LYS-D-PRO-THR

L-LYSYL-D-PROLYL-L-THREONINE

L-LYS-D-PRO-L-THR

interleukin1beta(193-195

(D-Pro194)-Interleukin-1b (193-195) (huMan), LDPT

(D-Pro194)-Interleukin-1β (193-195) (human)

2-[[[1-(2,6-diamino-1-oxohexyl)-2-pyrrolidinyl]-oxomethyl]amino]-3-hydroxybutanoic acid

L-Threonine, L-lysyl-D-prolyl-

(D-Pro194)-IL-1β (193-195) (human)

(2S,3R)-2-((R)-1-((S)-2,6-Diaminohexanoyl)pyrrolidine-2-carboxamido)-3-hydroxybutanoic acid

117027-34-6