COX-2
- Product Name
- COX-2
- Chemical Name
- COX-2
- Synonyms
- COX-2;PGHS-2;GRIPGHS;COX2, RAT;COX-2 HUMAN;EC 1.14.99.1;COX-2 (OVINE);COX-2 (SHEEP);COX2, RAT, 17AA;CYCLOOXYGENASE-2
- CBNumber
- CB1164608
- Formula Weight
- 0
- MOL File
- Mol file
COX-2 Property
- storage temp.
- −70°C
- form
- aqueous solution
- Specific Activity
- ≥8000units/mg protein
Safety
- WGK Germany
- -
- Storage Class
- 10 - Combustible liquids
N-Bromosuccinimide Price
- Product number
- C0858
- Product name
- Cyclooxygenase 2 human
- Purity
- ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, aqueous solution, ≥8000?units/mg protein
- Packaging
- 1000UNITS
- Price
- $520
- Updated
- 2025/07/31
- Product number
- 60122
- Product name
- COX-2 (human recombinant)
- Packaging
- 5kU
- Price
- $820
- Updated
- 2024/03/01
- Product number
- 382471
- Product name
- COX2
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
- Product number
- C7904-86
- Product name
- COX 2, Rat
- Packaging
- 100ug
- Price
- $347
- Updated
- 2021/12/16
- Product number
- ENZ0000168
- Product name
- COX-2 (SHEEP)
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.65
- Updated
- 2021/12/16
COX-2 Chemical Properties,Usage,Production
Description
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins.1,2 The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2; Item No. 17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020). COX-2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions.3 Thus, COX-2 has been the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Cayman's COX-2 (human, recombinant) contains an N-terminal hexahistidine tag and an alanine substituted for asparagine at position 580 (COX-2N580A) that prevents glycosylation at position 580 and decreases enzyme degradation in cells.4WARNING This product is not for human or veterinary use.
Biochem/physiol Actions
COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is the inducible form of cyclooxygenase, induced by phorbol esters, lipopolysaccharides, and cytokines. COX-2 is upregulated in the neovasculature of malignant tumors. Inhibition of COX-2 with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased tumor growth.
COX-2 Preparation Products And Raw materials
Raw materials
Preparation Products
COX-2 Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 4006800868;027-59626688 18371453821;18771149750
- sales@amyjet.com
- Country
- China
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- 2917
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- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
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- 58
- Tel
- 021-34661275 15301693058
- yajikit@163.com
- Country
- China
- ProdList
- 9921
- Advantage
- 58
- Tel
- 021-60345367 13916550749
- sales@shzbio.com
- Country
- China
- ProdList
- 9965
- Advantage
- 58
- Tel
- 400-901-9800 18611424007
- cis@bioss.com.cn
- Country
- China
- ProdList
- 9518
- Advantage
- 58
- Tel
- 02-400-810-9781 400810978
- sales@zsbio.com
- Country
- China
- ProdList
- 2887
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 400-6020407
- sales@wanleibio.com
- Country
- China
- ProdList
- 1216
- Advantage
- 58