N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE

Product Name: N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE
CAS No.: 152120-61-1
Chemical Name: N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE
Synonyms: N-Boc-pyrazoL;1-(N-Boc-carb;e-1-carboxamidine;N-Boc-1-guanylpyrazole;1-(N-Boc-amidino)pyrazole;N-Boc-pyrazole-1-carboxaMidine;H-pyrazole-1-carboxamidine HCl;Boc-1H-pyrazole-1-carboxamidine;N-BOC-1H-PYRAZOLE-1-CARBOXAMIDINE;N-Boc-1H-pyrazole-1-carboximidamide
CBNumber: CB1164996
Molecular Formula: C9H14N4O2
Formula Weight: 210.23
MOL File: 152120-61-1.mol

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N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE Property

Melting point:: 97-101 °C (lit.)
Density: 1.21
storage temp.: 2-8°C
form: powder to crystal
pka: 9.15±0.46(Predicted)
color: White to Almost white
BRN: 6141956
InChIKey: IGSFMHYSWZUENI-UHFFFAOYSA-N
CAS DataBase Reference: 152120-61-1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-60-37
WGK Germany: 3
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 442011
Product name: N-Boc-1H-pyrazole-1-carboxamidine
Purity: 97%
Packaging: 5g
Price: $44
Updated: 2023/06/20

TCI Chemical

Product number: B4028
Product name: N-(tert-Butoxycarbonyl)-1H-pyrazole-1-carboxamidine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $103
Updated: 2025/07/31

TRC

Product number: B656150
Product name: N-Boc-1-Guanylpyrazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Chem-Impex

Product number: 31243
Product name: N-Boc-1H-pyrazole-1-carboximidamide,≥99%(HPLC)
Purity: ≥99%(HPLC)
Packaging: 1G
Price: $13.5
Updated: 2021/12/16

Chem-Impex

Product number: 31243
Product name: N-Boc-1H-pyrazole-1-carboximidamide,≥99%(HPLC)
Purity: ≥99%(HPLC)
Packaging: 25G
Price: $104.83
Updated: 2021/12/16

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N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

peptide synthesis

Synthesis

24424-99-5

4023-02-3

152120-61-1

GENERAL STEPS: 1H-pyrazole-1-carboxamidine hydrochloride (9.0 g, 61.5 mmol, 1.0 eq.) and 9.0 mL of water were added to a solution of di-tert-butyl dicarbonate (13.4 g, 61.5 mmol) in acetone (45 mL) at room temperature. Subsequently, a solution of K2CO3 (4.24 g, 30.6 mmol, 0.5 eq.) in water (12.0 mL) was added slowly dropwise for 30 minutes. After 2 hours of reaction, di-tert-butyl dicarbonate (1.35 g, 6 mmol, 0.1 equiv) was added supplementally and the reaction mixture was stirred overnight. After completion of the reaction, the acetone was removed by distillation under reduced pressure. The resulting white solid was dissolved in 30.0 mL of water and stirred at 0 °C for 30 min. The precipitated tert-butyl (imino(1H-pyrazol-1-yl)methyl)carbamate was collected by filtration, washed sequentially with water and hexanes, and finally dried under vacuum to afford N-Boc-1H-pyrazole-1-carboxamidine as a colorless solid (11.37 g, 88% yield). The product was characterized by 1H NMR (CDCl3, 400MHz): δ 9.06 (brs, 1H), 8.45 (d, J = 3.2Hz, 1H), 7.67 (d, J = 0.8Hz, 1H), 7.59 (brs, 1H), 6.39 (dd, J = 2.8, 1.6Hz, 1H), 1.54 (s, 9H).

References

[1] Tetrahedron Letters, 2007, vol. 48, # 13, p. 2357 - 2359
[2] Organic and Biomolecular Chemistry, 2013, vol. 11, # 24, p. 3943 - 3948
[3] Patent: WO2015/147950, 2015, A2. Location in patent: Page/Page column 38
[4] Patent: US2013/79324, 2013, A1. Location in patent: Paragraph 0827; 0828
[5] Tetrahedron Letters, 1993, vol. 34, # 21, p. 3389 - 3392

N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE Suppliers

Americas 1 China 119 Europe 2 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 20 Global 152

J & K SCIENTIFIC LTD.

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View Lastest Price from N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-Boc-1-Guanylpyrazole 152120-61-1
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE 152120-61-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE 152120-61-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

152120-61-1, N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINERelated Search:

Aminoguanidine Sulfate N,N-BIS(TERT-BUTOXYCARBONYL)-1H-PYRAZOLE-1-CARBOXAMIDINE N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE N,N'-BIS(TERT-BUTOXYCARBONYL)-N-TETRAHYDROFURFURYL-1H-PYRAZOLE-1-CARBOXAMIDINE N,N'-BIS-BOC-1-GUANYLPYRAZOLE N,N'-BIS(TERT-BUTOXYCARBONYL)-N-(3-PICOLYL)-1H-PYRAZOLE-1-CARBOXAMIDINE N,N'-BIS(TERT-BUTOXYCARBONYL)-N-BENZYL-1H-PYRAZOLE-1-CARBOXAMIDINE

N-Boc-1H-pyrazole-1-carboximidamide≥ 99%(HPLC)

N-BOC-1H-PYRAZOLE-1-CARBOXAMIDINE

tert-Butyl (amino(1H-pyrazol-1-yl)methylene)carbamate

N-(tert-Butoxycarbonyl)-1H-pyrazole-1-carboxamidine

tert-Butyl N-(1H-pyrazole-1-carboximidoyl)carbamate

Boc-1H-pyrazole-1-carboxamidine

1-(N-Boc-amidino)pyrazole

N-(T-BUTOXYCARBONYL)-1H-PYRAZOLE-1-CARBOXAMIDINE

N-(TERT-BUTOXYCARBONYL)-1 H-PYRAZOLE-1-CARBOXAMIDINE

N-(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidi

Carbamic acid, (imino-1H-pyrazol-1-ylmethyl)-, 1,1-dimethylethyl ester (9CI)

N-Boc-pyrazole-1-carboxaMidine

N-Boc-1H-pyrazole-1-carboxaMidine, 98+%

CarbaMic acid, N-(iMino-1H-pyrazol-1-ylMethyl)-, 1,1-diMethylethyl ester

tert-butyl (NE)-N-(amino-pyrazol-1-yl-methylene)carbamate

tert-butyl (NE)-N-(amino-pyrazol-1-ylmethylidene)carbamate

tert-butyl (NZ)-N-(amino-pyrazol-1-yl-methylene)carbamate

tert-butyl (NZ)-N-(amino-pyrazol-1-ylmethylidene)carbamate

tert-butyl N-(amino-pyrazol-1-yl-methylene)carbamate

tert-butyl N-(amino-pyrazol-1-ylmethylidene)carbamate

tert-Butyl [(1E)-amino(1H-pyrazol-1-yl)methylene]carbamate

N-Boc-1-guanylpyrazole

2-Methyl-2-propanyl [aMino(1H-pyrazol-1-yl)Methylene]carbaMate

H-pyrazole-1-carboxamidine HCl

tert-butyl [amino(1H-pyrazol-1-yl)methyl]carbamate

(NE)-N-[amino-(1-pyrazolyl)methylene]carbamic acid te

(NZ)-N-[amino-(1-pyrazolyl)methylene]carbamic acid tert-butyl ester

N-[amino-(1-pyrazolyl)methylene]carbamic acid tert-butyl ester

N-(tert-Butoxycarbonyl)-1H-pyrazole-1-carboxamidine &gt

e-1-carboxamidine

N-Boc-pyrazoL

1-(N-Boc-carb

1-[N-(tert-Butoxycarbonyl)amidino]pyrazole

1-[N-(tert-Butoxycarbonyl)carbamimidoyl]pyrazole

N-(tert-Butoxycarbonyl)-1H-pyrazole-1-carboximidamide

N-Boc-1H-pyrazole-1-carboximidamide

N-tert-Butoxycarbonyl-1-amidinopyrazole

N-Boc-1H-pyrazole-1-carboxamidine

152120-61-1

Guanidine Protection/Guanidinylation

Peptide Synthesis

Specialty Synthesis

N-BOC

Guanidine Protection/Guanidinylation

Peptide Synthesis

Specialty Synthesis