Uses
ChemicalBook > CAS DataBase List > N,N'-BIS-BOC-1-GUANYLPYRAZOLE

N,N'-BIS-BOC-1-GUANYLPYRAZOLE

Uses
Product Name
N,N'-BIS-BOC-1-GUANYLPYRAZOLE
CAS No.
152120-54-2
Chemical Name
N,N'-BIS-BOC-1-GUANYLPYRAZOLE
Synonyms
tert-Butyl [(Boc-aMino)(1H-pyrazol-1-yl)Methylene]carbaMate;tert-Butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate;uanyL;Boc-Pyrazol;PYRAZOL(BOC)2;PYRAZOLE(BOC)2;N,N'-Bis-boc-1-g;N,N'-Bis-boc-1-guanyL;Laninamivir Impurity 4;N,N'-Bis-Boc-1-Guanylpyrazol
CBNumber
CB3679544
Molecular Formula
C14H22N4O4
Formula Weight
310.35
MOL File
152120-54-2.mol
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N,N'-BIS-BOC-1-GUANYLPYRAZOLE Property

Melting point:
86-90 °C(lit.)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slghtly), Methanol (Slightly)
form 
Solid
pka
6.92±0.46(Predicted)
color 
White to Off-White
Water Solubility 
Slightly soluble in water. Soluble in methanol, and chloroform.
InChI
InChI=1S/C14H22N4O4/c1-13(2,3)21-11(19)16-10(18-9-7-8-15-18)17-12(20)22-14(4,5)6/h7-9H,1-6H3,(H,16,17,19,20)
InChIKey
QFNFDHNZVTWZED-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)/N=C(/NC(OC(C)(C)C)=O)\N1C=CC=N1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
434167
Product name
N,N′-Di-Boc-1H-pyrazole-1-carboxamidine
Purity
98%
Packaging
1g
Price
$30
Updated
2025/07/31
Sigma-Aldrich
Product number
434167
Product name
N,N′-Di-Boc-1H-pyrazole-1-carboxamidine
Purity
98%
Packaging
5g
Price
$89
Updated
2025/07/31
TCI Chemical
Product number
B3619
Product name
N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B3619
Product name
N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$98
Updated
2025/07/31
Sigma-Aldrich
Product number
434167
Product name
N,N′-Di-Boc-1H-pyrazole-1-carboxamidine
Purity
98%
Packaging
25g
Price
$316
Updated
2025/07/31
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N,N'-BIS-BOC-1-GUANYLPYRAZOLE Chemical Properties,Usage,Production

Uses

N,N'-Di-Boc-1H-pyrazole-1-carboxamidine is used in the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin.N,N'-Di-Boc-1H-pyrazole-1-carboxamidine (also known as Bis-Boc-pyrazolocarboxamidine,Pyrazol(BOC)2) is typically used as a guanidinylating reagent in organic synthesis.

Chemical Properties

White solid

Uses

N,N'-Di-Boc-1H-pyrazole-1-carboxamidine is used in the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin.

Synthesis

24424-99-5

152120-61-1

152120-54-2

Step F-2: Synthesis of tert-butyl (tert-butoxycarbonyliminopyrazol-1-yl - methyl) carbamate [Compound (H) N-Boc-1H-pyrazole-1-carboxamidine (50 g) prepared in step BI was dissolved in tetrahydrofuran (100 ml) and slowly added to a suspension of 60% sodium hydride (9.99 g) in tetrahydrofuran (100 ml) over a period of 1 h. The temperature of the reaction was maintained at -5°C to 0°C. After 30 minutes of continuous stirring at this temperature, a solution of tetrahydrofuran (100 ml) of di-tert-butyl dicarbonate (57.1 g) was added dropwise, keeping the temperature constant. Subsequently tetrahydrofuran (250 ml) was added and the reaction mixture was heated and stirred at reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, the reaction was quenched by the addition of acetic acid (20.4 ml) and concentrated under reduced pressure to about 150 ml. 5% aqueous sodium bicarbonate solution (500 ml) was added to the concentrate and extracted with ethyl acetate (500 ml). The organic layer was washed with water (150 ml) and concentrated under reduced pressure to about 75 ml. Hexane (200 ml) was added to the residue and inoculated with crystals, which were stirred under cooling in an ice bath for 40 min. The crystals were collected by filtration, washed with hexane (50 ml) and dried under reduced pressure to give N,N'-di-BOC-1H-1 -guanidinopyrazole (54.47 g, 73.8% yield). 1H NMR (CDCl3, 500MHz): δ 1.49 (9H, s), 1.55 (9H, s), 6.41 (1H, dd, J = 1.5, 2.7Hz), 7.62 (1H, dd, J = 0.7, 1.5Hz), 8.30 (1H, dd, J = 0.7, 2.7Hz), 8.93 (1H, brs). 13C NMR (CDCl3, 125MHz): δ 28.1, 28.2, 81.4, 83.4, 109.8, 129.0, 139.2, 142.8, 149.4, 157.4.

References

[1] Patent: WO2008/126943, 2008, A2. Location in patent: Page/Page column 79-80
[2] Synthesis, 2004, # 10, p. 1655 - 1663
[3] Tetrahedron Letters, 1993, vol. 34, # 21, p. 3389 - 3392
[4] Synthetic Communications, 1993, vol. 23, # 21, p. 3055 - 3060

N,N'-BIS-BOC-1-GUANYLPYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-BIS-BOC-1-GUANYLPYRAZOLE Suppliers

Americas 1 China 232 Europe 1 France 1 Germany 5 India 6 Japan 1 Switzerland 3 United Kingdom 4 United States 30 Global 284
Suzhou Highfine Biotech Co., Ltd
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View Lastest Price from N,N'-BIS-BOC-1-GUANYLPYRAZOLE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N,N'-BIS-BOC-1-GUANYLPYRAZOLE 152120-54-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
N,N"-BIS-BOC-1-GUANYLPYRAZOLE 152120-54-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N,N"-BIS-BOC-1-GUANYLPYRAZOLE 152120-54-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

152120-54-2, N,N'-BIS-BOC-1-GUANYLPYRAZOLERelated Search:

Aminoguanidine Sulfate tert-butyl ((1R,2R)-2-(hydroxymethyl)cyclopentyl)carbamate (1R,2R)-trans-N-Boc-2-Aminocyclohexanol tert-butyl ((1R,2S)-2-(aminomethyl)cyclopentyl)carbamate N,N'-BIS(TERT-BUTOXYCARBONYL)-N-BENZYL-1H-PYRAZOLE-1-CARBOXAMIDINE N,N'-BIS(TERT-BUTOXYCARBONYL)-N-(3-PICOLYL)-1H-PYRAZOLE-1-CARBOXAMIDINE N,N'-BIS-BOC-1-GUANYLPYRAZOLE N,N'-BIS(TERT-BUTOXYCARBONYL)-N-TETRAHYDROFURFURYL-1H-PYRAZOLE-1-CARBOXAMIDINE

  • N,N''-Bis-(tert-butoxycarbonyl)-1-guanylpyrazole
  • N,N'-DiBoc-1H-Pyrazole Guanidine
  • N,N-Bis-(t-butyloxycarbonyl)-1-guanylpyrazole, N,N-Di-Boc-1H-pyrazole-1-carboxamidine
  • N,N'-BIS-(T-BUTYL-OXYCARBONYL)-1-GUANYLPYRAZOLE
  • N,N'-BIS-BOC-1-GUANYLPYRAZOLE
  • N,N'-BIS-(TERT-BUTYLOXYCARBONYL)-1-GUANYLPYRAZOLE
  • PYRAZOLE(BOC)2
  • PYRAZOL(BOC)2
  • N,N''-bis-Boc-1-guanylpyrazole [Pyrazole(Boc)]
  • (NZ)-N-[[[(2-methylpropan-2-yl)oxy-oxometh
  • N,N'-Di-Boc-1H-pyrazole-1-carboxamidine 98%
  • tert-Butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate
  • N,N''-Bis-(tert-butoxycarbonyl)-1-guanylpyr
  • 1H-Pyrazole-1-carboxamidine, N,N'-Bis-BOC protected 97%
  • 1-[N,N'-Bis(tert-butoxycarbonyl)amidino]pyrazole
  • Boc-Pyrazol
  • N,N'-Di-Boc-1H-pyrazole-1-carboxamide
  • N,N'-Bis-Boc-1-Guanylpyrazol
  • Bis-Boc-pyrazolocarboxamidine
  • 1H-Pyrazole-1-carboxamidine, N,N'-Bis-BOC protected
  • N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboximidamide
  • Pyrazol(Boc)2 N,N'-Bis-Boc-1-Guanylpyrazole
  • N,N'-Di-Boc-1H-pyrazole-1-carboxamidine
  • Tert-butyl (1H-pyrazol-1-yl) MethanediylidenedicarbaMate
  • N,N'-Di-Boc-1H-pyrazole-1-carboxaMidine, 98+%
  • N,N'-Di-Boc-1H-pyrazole-1-carboxamidine 1-[N,N'-bis(tert-butoxycarbonyl)amidino]pyrazole 1-[N,N'-(Di-Boc)amidino]pyrazole
  • Pyrazol(Boc)2 N,N'-Bis-Boc-1-Guanylpyrazol
  • tert-Butyl [(Boc-aMino)(1H-pyrazol-1-yl)Methylene]carbaMate
  • CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazol-1-ylMethylene]-, 1,1-diMethylethyl ester
  • tert-butyl N-[(tert-butoxy)carbonyl]-N-[(1H-pyrazol-1-yl)carbonyl]carbaMate
  • N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboximidamide, 1-[N,N'-Bis(tert-butoxycarbonyl)carbamimidoyl]-1H-pyrazole
  • tert-Butyl (((tert-butoxycarbonyl)aMino)(1H-pyrazol-1-yl)Methylene)carbaMate
  • tert-Butyl [(Boc-aMino)(1H-pyrazol-1-yl)Methylene]carbaMate, 95+%
  • N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine &gt
  • N,N'-Bis-boc-1-g
  • uanyL
  • N,N'-Bis-boc-1-guanyL
  • 1-[N,N'-(Di-Boc)amidino]pyrazole
  • 1-[N,N'-Bis(tert-butoxycarbonyl
  • N,N'-Di-Boc-1H-pyrazole-1-carboximidamide
  • tert-butyl -N-[[(2-methylpropan-2-yl)oxycarbonylamino]-pyrazol-1-ylmethylidene]carbamate
  • tert-Butyl (NZ)-N-[(tert-butoxycarbonylamino)-pyrazol-1-yl-methylene]carbamate
  • 152120-54-2 N,N'-BIS-BOC-1-GUANYLPYRAZOLE
  • tert-butyl (NZ)-N-[[(2-methylpropan-2-yl)oxycarbonylamino]-pyrazol-1-ylmethylidene]carbamate
  • Zanamivir / ranimivir intermediate
  • tert-butyl N-[(tert-butoxycarbonylamino)-pyrazol-1-yl-methylene]carbamate
  • N. N '- Di Boc-1H-1-Guanylpyrazole
  • Pyrazol(Boc)2N,N'-Bis-Boc-1-Guanylpyrazol
  • N,N'-Di-Boc-pyrazole-1-carboxamidine
  • Laninamivir Impurity 4
  • <i>N,N′</i>-Di-Boc-1<i>H</i>-pyrazole-1-carboxamidine
  • N,N′-Di-Boc-1H-pyrazole-1-carboxamidine, CAS 152120-54-2
  • 152120-54-2
  • C14H22N4O4
  • Specialty Synthesis
  • Peptide Synthesis
  • Guanidine Protection/Guanidinylation
  • Peptide Synthesis