6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE

Uses

Product Name: 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE
CAS No.: 88145-89-5
Chemical Name: 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE
Synonyms: 6-bromoquinazoline-2,4(1H,3H)-dione;6-Bromoquinazoline-2,4-dione;6-broMo-1,2,3,4-tetrahydroquin;6-bromo-1H-quinazoline-2,4-dione;6-Bromo-1H,3H-quinazoline-2,4-dione;6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE;2,4(1H,3H)-Quinazolinedione, 6-bromo-;6-Bromoquinazoline-2,4(1H,3H)-dione,97%;6-broMo-1,2,3,4-tetrahydroquinazoline-2,4-dione
CBNumber: CB1166107
Molecular Formula: C8H5BrN2O2
Formula Weight: 241.04
MOL File: 88145-89-5.mol

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6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE Property

Melting point:: >300
Density: 1.752±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: Solid
pka: 10.37±0.20(Predicted)
color: Off-white
InChI: InChI=1S/C8H5BrN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)
InChIKey: JZDVFUAHGLJVQG-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(Br)C=C2)C(=O)NC1=O
CAS DataBase Reference: 88145-89-5

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B688253
Product name: 6-Bromoquinazoline-2,4(1H,3H)-dione
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: A980
Product name: 6-Bromo-2,4(1H,3H)-quinazolinedione
Packaging: 1g
Price: $89
Updated: 2021/12/16

Matrix Scientific

Product number: 046995
Product name: 6-Bromo-2,4(1H,3H)-quinazolinedione
Purity: 95%
Packaging: 5g
Price: $89
Updated: 2021/12/16

Apolloscientific

Product number: OR12053
Product name: 6-Bromoquinazoline-2,4(1H,3H)-dione
Packaging: 5g
Price: $89
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-9-Z7
Product name: 6-Bromoquinazoline-2,4(1H,3H)-dione
Packaging: 5G
Price: $98
Updated: 2021/12/16

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6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE Chemical Properties,Usage,Production

Uses

6-Bromoquinazoline-2,4-dione, also known as hexabromoquinazoline-2,4(1H,3H)-dione, is a common derivative of quinazoline-2,4-one. Quinazoline ones are an important class of compounds containing pyrimidine heterocycles. Due to their simple structure and ease of modification, they are important intermediates in fine chemical and pharmaceutical synthesis and are widely used in antibacterial, anti-inflammatory, antihypertensive, anticonvulsant, and antitumor drugs. Quinazoline-2,4-dione derivatives possess excellent biological activities and have been widely used in pesticides and pharmaceuticals, exhibiting bactericidal, herbicidal, insecticidal, anticonvulsant, and neuroprotective activities. Among them, 6-substituted 2,4-quinazoline diones, due to their broad biological activities, can be used as drugs such as anti-HIV agents and protein tyrosine kinase inhibitors, and also as pesticides such as insecticides and fungicides.

Synthesis

124-38-9

39263-32-6

88145-89-5

General procedure for the synthesis of 6-bromoquinazoline-2,4-dione from carbon dioxide and 2-amino-5-bromobenzonitrile: 2-amino-5-bromobenzonitrile (10 g, 52 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (30 mL, 200 mmol) were dissolved in dimethylformamide (DMF) (50 mL) at The reaction was stirred in a carbon dioxide atmosphere (maintained by an attached latex balloon) under oil bath heating at 100 °C for 48 hours. Upon completion of the reaction, the reaction solution was removed from the heating source and slowly poured into ice bath cooled 1N HCl solution (500 mL) to precipitate a solid. The solid product was collected by filtration, washed with deionized water and dried to give 6-bromo-1H-quinazoline-2,4-dione as a yellow solid (12 g, quantitative yield). Thin layer chromatography (TLC) analysis showed an Rf value of 0.27 (unfolding agent: dichloromethane solution in 5% methanol).1H NMR (DMSO-d6, 300 MHz) δ 11.41 (s, 1H), 11.27 (s, 1H), 7.91 (d, J = 2.3 Hz, 1H), 7.77 (dd, J1 = 8.8 Hz, J2 = 2.3 Hz, 1H), 7.11 (dd, J1 = 8.8 Hz, J2 = 2.3 Hz, 1H), 7.11 (dd, J1 = 2.3 Hz, 2.3 Hz, 2.3 Hz, 1H). 1H), 7.11 (d, J = 8.8 Hz, 1H). Electrospray ionization mass spectrometry (ESI-MS) analysis: m/z calculated value C8H5BrN2O2 [M]+: 240.0; measured value: 241.0 [M+H]+.

References

[1] Patent: WO2004/99159, 2004, A1. Location in patent: Page 34; 58; 68
[2] RSC Advances, 2015, vol. 5, # 7, p. 5032 - 5037
[3] Catalysis Science and Technology, 2016, vol. 6, # 5, p. 1435 - 1441
[4] Tetrahedron, 2018, vol. 74, # 24, p. 2914 - 2920
[5] RSC Advances, 2015, vol. 5, # 20, p. 15668 - 15673

6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE Suppliers

China 111 Germany 1 India 2 United Kingdom 2 United States 11 Global 127

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View Lastest Price from 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE manufacturers

Career Henan Chemical Co

Product: 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE 88145-89-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

88145-89-5, 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONERelated Search:

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone bromchlorenone 6-Bromoquinazoline 6,8-Dibromoquinazoline-2,4(1H,3H)-dione 4-BROMOPHENYLUREA 6-bromo-3-ethyl-2,4(1H,3H)-quinazolinedione 2-AMINO-5-BROMOBENZAMIDE 2-(AMINOMETHYL)-4-BROMOANILINE Benzoyleneurea 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE

6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE

6-Bromo-1H,3H-quinazoline-2,4-dione

6-bromoquinazoline-2,4(1H,3H)-dione

6-bromo-1H-quinazoline-2,4-dione

6-broMo-1,2,3,4-tetrahydroquinazoline-2,4-dione

6-broMo-1,2,3,4-tetrahydroquin

6-Bromoquinazoline-2,4-dione

2,4(1H,3H)-Quinazolinedione, 6-bromo-

6-Bromoquinazoline-2,4(1H,3H)-dione,97%

88145-89-5