2-Pyridinol-1-oxide

Product Name: 2-Pyridinol-1-oxide
CAS No.: 13161-30-3
Chemical Name: 2-Pyridinol-1-oxide
Synonyms: HOPO;2-HYDROXYPYRIDINE 1-OXIDE;2-HYDROXYPYRIDINE N-OXIDE;HPNO;1-oxide;1-HYDROXY-2-PYRIDONE;1-hydroxypyridin-2-one;2-Hydorxy Pyridine-N-Oxide;2-HYDROXYPYRIDINE N-OXIDE 98%;2-pyridinol-1-oxide
CBNumber: CB1168000
Molecular Formula: C5H5NO2
Formula Weight: 111.1
MOL File: 13161-30-3.mol

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2-Pyridinol-1-oxide Property

Melting point:: 147-152 °C
Boiling point:: 387.7±15.0 °C(Predicted)
Density: 1.111
vapor pressure: 0.223Pa at 25℃
refractive index: 1.388
Flash point:: 100 °C
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
pka: pK1:-0.62;pK2:5.97(0) (25°C)
color: Off-White to Light Yellow
Water Solubility: 331g/L
BRN: 1422545
InChI: 1S/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H
InChIKey: JVHZMYAXZUIZKS-UHFFFAOYSA-N
SMILES: Oc1cccc[n+]1[O-]
LogP: -1.07 at 25℃
CAS DataBase Reference: 13161-30-3(CAS DataBase Reference)
NIST Chemistry Reference: 2-Pyridinol-1-oxide(13161-30-3)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-40
Safety Statements: 26-36-22
WGK Germany: 3
HS Code: 29333990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 56413
Product name: 2-Pyridinol 1-oxide
Purity: ≥98.0% (N)
Packaging: 25g
Price: $132
Updated: 2026/03/19

Sigma-Aldrich

Product number: 56413
Product name: 2-Pyridinol 1-oxide
Purity: ≥98.0% (N)
Packaging: 100g
Price: $288
Updated: 2026/03/19

TCI Chemical

Product number: H0672
Product name: 2-Hydroxypyridine N-Oxide
Purity: >98.0%(T)
Packaging: 25g
Price: $42
Updated: 2026/03/19

Usbiological

Product number: 278689
Product name: 2-Hydroxypyridine N-Oxide
Packaging: 50g
Price: $330
Updated: 2021/12/16

TRC

Product number: H953633
Product name: 2-Hydroxypyridine N-Oxide
Packaging: 25g
Price: $70
Updated: 2021/12/16

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2-Pyridinol-1-oxide Chemical Properties,Usage,Production

Chemical Properties

Weight 20% solution in water

Uses

2-Pyridinol 1-oxide can be used:

To fabricate gold electrodes for the electrochemical determination of europium using cyclic voltammetry.
To prepare polymeric nickel (II) complex of 2-hydroxypyridine-N-oxide.
In the synthesis of 1-methoxypyrid-4-one in the presence of sodium methoxide and methyl toluene-9-sulphonate.

Definition

Bactericidal agent related to aspergillic acid, made from pyridine-N-oxide.

General Description

2-Pyridinol 1-oxide (HOPO) is a peptide coupling agent used as a subsititue for HOBt. It can form stable chelate complexes with transition metal ions.

Synthesis

500L reactor add 2-chloropyridine 30 kg, 200 kg of tap water, sodium tungstate 1.5 kg, 2 kg of concentrated sulfuric acid, stirring to dissolve clear; temperature to 55 , slowly drop 30% hydrogen peroxide 100 kg; drop after the completion of the temperature to continue to react for 48 hours, HPLC test raw material conversion rate of 84%, cooled down to room temperature, add 12.3 kg of liquid alkali adjusted to neutral. Add toluene 50 kg, extract the raw material is not fully reacted (the layer can be concentrated to recover toluene and raw materials); aqueous layer to add 20 kg of sodium hydroxide, reflux reaction for 8 hours, HPLC monitoring, showing that the raw material is fully converted, cooled down to 25 C, add hydrochloric acid to adjust the PH = 6, add ethyl acetate extraction, each time the dosage of 30 kg, extract three times, the combined organic phase, with anhydrous sodium sulfate 15 kg drying ; filter, concentrate the organic phase to 1/5 of the original volume, add 85 kg of 60-90 C petroleum ether, cooled to -5 C, stirring crystallization; filtration, drying, to obtain a light yellow crystal powder 22.9 kg, yield: 78.05% (calculated as 2-chloropyridine, and did not calculate the recovery of 2-chloropyridine).

References

[1] Laura Cruickshank. “Rare Elements Electrochemistry: The Development of a Novel Electrochemical Sensor for the Rapid Detection of Europium in Environmental Samples Using Gold Electrode Modified with 2-pyridinol-1-oxide.” Analytical Sciences 31 7 (2015): 623–627.

2-Pyridinol-1-oxide Preparation Products And Raw materials

Raw materials

2-Methoxypyridine Hydrogen peroxide Hydrochloric acid Acetic acid

Preparation Products

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2-Pyridinol-1-oxide Suppliers

Americas 1 Belgium 1 Canada 1 China 342 Europe 1 France 3 Germany 7 India 25 Ireland 1 Israel 2 Italy 1 Japan 1 Switzerland 3 The Netherlands 1 United Kingdom 17 United States 32 Global 439

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View Lastest Price from 2-Pyridinol-1-oxide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Pyridinol-1-oxide 13161-30-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Pyridinol-1-oxide 13161-30-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Pyridinol-1-oxide 13161-30-3
Price: US $20.00-5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-26

13161-30-3, 2-Pyridinol-1-oxideRelated Search:

Hydroxy silicone oil ETHYLENE OXIDE Cuprous oxide Sulfasalazine 2-Chloro-5-chloromethylpyridine Chromium picolinate 2,5-Dimethylpyridine 2-Hydroxypyridine NITRIC OXIDE Magnesium oxide Iron oxide PYRIDINE-D5 Pyridine-N-oxide Propylene oxide Zinc oxide Cetylpyridinium chloride monohydrate 2-(Hydroxymethyl)pyridine 2,3,4-Trihydroxybenzoic acid

Pyridinium,1,2-dihydroxy-,1-hydroxide,inner salt

2-Hydorxy Pyridine-N-Oxide

2-HYDROXYPYRIDINE N-OXIDE 98%

2-HYDROXYPYRIDINE N-OXIDE 98+%

2-HYDROXYPRIDINE-N-OXIDE

2-Hydroxypyridine-N-oxide, 2-Pyridinol N-oxide, 1-Hydroxy-2-pyridone

HPNO

1-Hydroxy-2-pyridone, 2-Pyridinol N-oxide

1-hydroxypyridin-2-one

1-oxide

HPNO 2-Pyridinol-1-oxide

2-hydroxy-1$l^{5}-pyridin-1-one

HOPO 2-Pyridinol-1-Oxide

The 2-hydroxyl pyridine-N- oxide

2-Hydroxypyridine-N-xoide

1 HYDROXY-2(1H)-PYRIDINONE

1-HYDROXY-2-PYRIDONE

2-pyridinol-1-oxide

2-PYRIDINOL N-OXIDE

2-Pyridinol 1-oxide >=98.0% (N)

2-Pyridinol-1-oxide(HOPO)

2-hydroxypyridine oxide

TIMTEC-BB SBB004330

PYRIDIN-2-OL 1-OXIDE

2-HydroxypyridineN-Oxide&gt

2-Pyridinol-1-oxide ISO 9001：2015 REACH

WIDELY 2-Pyridinol-1-oxide

Daclatasvir Impurity-T

2-Pyridinol-N-oxide (HOPO)

TIANFUCHEM--13161-30-3---2-Pyridinol-1-oxide

Pyridinium,1,2-dihydroxy-

2-Hydroxypyridine-N-oxide pure (HOPO), 98%

2-hydroxy-1λ?-pyridin-1-one

2-Pyridinol 1-oxide, 98%

2-Hydroxypyridine-N-oxide - [H82318]

HOPO

2-HYDROXYPYRIDINE 1-OXIDE

2-HYDROXYPYRIDINE N-OXIDE

13161-30-3

C5H5N1O2

C5

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