3-HYDROXY-P-BUTYROPHENETIDINE
- Product Name
- 3-HYDROXY-P-BUTYROPHENETIDINE
- CAS No.
- 1083-57-4
- Chemical Name
- 3-HYDROXY-P-BUTYROPHENETIDINE
- Synonyms
- BUCETIN;betadid;BUCETINE;LABOTEST-BB LT00771786;Inhibitor,Bucetin,inhibit;3-hydroxy-p-butyrophenetidid;3-hydroxybutyr-4-phenetidide;3-HYDROXY-P-BUTYROPHENETIDIDE;3-HYDROXY-P-BUTYROPHENETIDINE;4’-ethoxy-3-hydroxy-butyranilid
- CBNumber
- CB1168297
- Molecular Formula
- C12H17NO3
- Formula Weight
- 223.27
- MOL File
- 1083-57-4.mol
3-HYDROXY-P-BUTYROPHENETIDINE Property
- Melting point:
- 160 °C
- Boiling point:
- 364.56°C (rough estimate)
- Density
- 1.1223 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- pka
- 14.07±0.70(Predicted)
- color
- White to Off-White
- Merck
- 14,1458
- CAS DataBase Reference
- 1083-57-4
- EPA Substance Registry System
- Butanamide, N-(4-ethoxyphenyl)-3-hydroxy- (1083-57-4)
Safety
- Hazard Codes
- T
- Risk Statements
- 45-46-20/21/22
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- EU0900000
- HS Code
- 2924.29.7790
- Toxicity
- LD50 in mice (mg/kg): 790 i.p., 2800 orally (Fujimura)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B4027
- Product name
- Bucetin
- Purity
- analytical standard
- Packaging
- 10g
- Price
- $26.7
- Updated
- 2022/05/15
- Product number
- H0371
- Product name
- 3-Hydroxy-p-butyrophenetidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- B689420
- Product name
- Bucetin
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CHM0010550
- Product name
- 3-HYDROXY-P-BUTYROPHENETIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $626.08
- Updated
- 2021/12/16
- Product number
- 44114
- Product name
- Bucetin
- Packaging
- 10g
- Price
- $650
- Updated
- 2021/12/16
3-HYDROXY-P-BUTYROPHENETIDINE Chemical Properties,Usage,Production
Originator
Bucetin,ZYF Pharm Chemical
Uses
Bucetin is an antipyretic and analgesic drug that is chemically similar to phenacetin. The use of Bucetin has been withdrawn due to renal toxicity.
Uses
3-Hydroxy-p-butyrophenetidine is an antipyretic and analgesic drug that is chemically similar to phenacetin (P294580). The use of 3-Hydroxy-p-butyrophenetidine has been withdrawn due to renal toxicity.
Definition
ChEBI: Bucetin is an organic molecular entity.
Manufacturing Process
Bucetin may be prepared from acetoacetic acid p-phenetidide as follows:
5.5 parts of acetoacetic acid p-phenetidide, suspended in 600 parts by volume
of methanol, are hydrogenated at 80°-85°C with a nickel catalyst supported
on kiesel-guhr. When the theoretical quantity of hydrogen has been absorbed,
the solution is cooled, then filtered, and the filtrate is concentrated. The solid
residue is recrystallized from six times its weight of isopropanol. β-
Hydroxybutyric acid p-phenetidide is obtained in an almost quantitative yield
in the form of white crystals which melt at 160°C.
55 parts of acetoacetic acid p-phenetidide, suspended in 500 parts by volume
of methanol, are hydrogenated with Raney nickel at 70°C. When the
theoretical quantity of hydrogen has been absorbed, the solution is cooled,
then filtered, and the filtrate is concentrated. The solid residue is recrystallized
from six times its weight of isopropanol. 51 parts (93 % of the theoretical
yield) of β-hydroxybutyric acid p-phenetidide are obtained in the form of white
crystals, which are sparingly soluble in water and melt at 160°C.
A mixture of 5 g of aluminum amalgam, 5 g of acetoacetic acid p-phenetidide
and 50 ml of ethanol are gently heated for 30 minutes. After filtering off the
reducing agent with suction, water is added to the filtrate, and the latter is
then acidified with 2 N hydrochloric acid. β-Hydroxybutyric acid p-phenetidide
melting at 160°C crystallizes in almost quantitative yield in the form of white
crystals.
brand name
Beelin;Bonanza;Haitmin;Hoe 15239;New isomidon;Ringl-s.
Therapeutic Function
Analgesic
World Health Organization (WHO)
Bucetin is an analogue of phenacetin. See WHO comment for phenacetin.
3-HYDROXY-P-BUTYROPHENETIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-HYDROXY-P-BUTYROPHENETIDINE manufacturers
- Product
- 3-HYDROXY-P-BUTYROPHENETIDINE 1083-57-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 3-HYDROXY-P-BUTYROPHENETIDINE 1083-57-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-29