3-(4-Chlorophenyl)propan-1-ol
- Product Name
- 3-(4-Chlorophenyl)propan-1-ol
- CAS No.
- 6282-88-8
- Chemical Name
- 3-(4-Chlorophenyl)propan-1-ol
- Synonyms
- Pitolisant Impurity 9;4-Chlorobenzenepropanol;Benzenepropanol, 4-chloro-;3-(4-CHLOROPHENYL)PROPANOL;3-(4'-CHLOROPHENYL)PROPANOL;3-(4-Chlorophenyl)propanol95%;3-(4-CHLOROPHENYL)PROPAN-1-OL;3-(4-Chlorophenyl)propanol 95%;2-(1-oxoheptyl)indene-1,3-dione;3-(4-CHLOROPHENYL)PROPAN-1-OL 98%
- CBNumber
- CB1168752
- Molecular Formula
- C9H11ClO
- Formula Weight
- 170.64
- MOL File
- 6282-88-8.mol
3-(4-Chlorophenyl)propan-1-ol Property
- Boiling point:
- 104°C 0,1mm
- Density
- 1.151±0.06 g/cm3(Predicted)
- refractive index
- 1.54
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 15.03±0.10(Predicted)
- color
- Colorless to Yellow
- InChI
- InChI=1S/C9H11ClO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-6,11H,1-2,7H2
- InChIKey
- ZHBIWFGGIKFSHZ-UHFFFAOYSA-N
- SMILES
- C1(CCCO)=CC=C(Cl)C=C1
- CAS DataBase Reference
- 6282-88-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41
- Safety Statements
- 26-36/37/39-24/25-39
- HazardClass
- IRRITANT
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CDS003137
- Product name
- 3-(4-Chlorophenyl)-1-propanol
- Purity
- AldrichCPR
- Packaging
- 500MG
- Price
- $70.9
- Updated
- 2024/03/01
- Product number
- C3527
- Product name
- 3-(4-Chlorophenyl)propan-1-ol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- C3527
- Product name
- 3-(4-Chlorophenyl)propan-1-ol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- C596505
- Product name
- 3-(4-Chlorophenyl)propan-1-ol
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- C596505
- Product name
- 3-(4-Chlorophenyl)propan-1-ol
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
3-(4-Chlorophenyl)propan-1-ol Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid.
Uses
3-(4-Chlorophenyl)propan-1-ol is used in preparation of 2-Oxo-2H-chromene-3-carboxylic Acid Amide derivatives as Aldo-Keto reductase inhibitors.
Definition
ChEBI: 3-(4-Chlorophenyl)propan-1-ol is an organochlorine compound.
Synthesis
1615-02-7
6282-88-8
General procedure for the synthesis of 3-(4-chlorophenyl)propan-1-ol from p-chlorocinnamic acid: yield range 23.3-88.0%. As an example, 3-(4-chlorophenyl)propan-1-ol (3c) was synthesized as follows: under nitrogen protection and an ice bath, a THF solution of 3-(4-chlorophenyl)acrylic acid (2c, 2.74 g, 15 mmol) was slowly added to a tetrahydrofuran (THF, 30 mL) suspension of lithium aluminium hydride (1.71 g, 45 mmol), and the addition process was controlled to be completed within 30 min. The addition process was controlled to be completed within 30 min. The reaction mixture was stirred to room temperature and then continued to reflux for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was cooled to room temperature. Subsequently, methanol (15 mL) and water (15 mL) were added slowly and dropwise to quench the reaction and the pH was adjusted with 10% hydrochloric acid solution to 3. The crude product was extracted with ethyl acetate (3 x 30 mL), the organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The resulting yellow oil was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=4:1, v/v) to give a yellow oily target product in 54.7% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.27-7.22 (m, 2H), 7.15-7.10 (m, 2H), 3.66 (t, J=6.4 Hz, 2H), 2.68 (t, J=7.44 Hz, 2H), 1.91-1.81 (m, 2H).
References
[1] Chinese Chemical Letters, 2016, vol. 27, # 4, p. 555 - 558
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 7, p. 1849 - 1853
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 18, p. 4752 - 4756
3-(4-Chlorophenyl)propan-1-ol Preparation Products And Raw materials
Raw materials
Preparation Products
3-(4-Chlorophenyl)propan-1-ol Suppliers
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View Lastest Price from 3-(4-Chlorophenyl)propan-1-ol manufacturers
- Product
- 3-(4-Chlorophenyl)propan-1-ol 6282-88-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-(4-Chlorophenyl)propan-1-ol 6282-88-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-18