ChemicalBook > CAS DataBase List > 2-chloro-N-(2,2,2-trifluoroethyl)acetamide

2-chloro-N-(2,2,2-trifluoroethyl)acetamide

Product Name
2-chloro-N-(2,2,2-trifluoroethyl)acetamide
CAS No.
170655-44-4
Chemical Name
2-chloro-N-(2,2,2-trifluoroethyl)acetamide
Synonyms
2-chloro-N-(2,2,2-trifluoroethyl)acetamide;2-CgHLORO-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE;AcetaMide, 2-chloro-N-(2,2,2-trifluoroethyl)-
CBNumber
CB11690689
Molecular Formula
C4H5ClF3NO
Formula Weight
175.54
MOL File
170655-44-4.mol
More
Less

2-chloro-N-(2,2,2-trifluoroethyl)acetamide Property

Boiling point:
218 ºC
Density 
1.368
Flash point:
86 ºC
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
11.89±0.46(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C4H5ClF3NO/c5-1-3(10)9-2-4(6,7)8/h1-2H2,(H,9,10)
InChIKey
IRIXZMVHMMALGW-UHFFFAOYSA-N
SMILES
C(NCC(F)(F)F)(=O)CCl
More
Less

Safety

HS Code 
2924297099
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
C422155
Product name
2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
Packaging
1g
Price
$310
Updated
2021/12/16
ChemScene
Product number
CS-W021673
Product name
2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
Purity
>98.0%
Packaging
1g
Price
$85
Updated
2021/12/16
AK Scientific
Product number
8756AA
Product name
2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
Packaging
250mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
097141
Product name
2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
Purity
95+%
Packaging
1g
Price
$265
Updated
2021/12/16
ChemScene
Product number
CS-W021673
Product name
2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
Purity
>98.0%
Packaging
5g
Price
$295
Updated
2021/12/16
More
Less

2-chloro-N-(2,2,2-trifluoroethyl)acetamide Chemical Properties,Usage,Production

Synthesis

373-88-6

79-04-9

170655-44-4

GENERAL STEPS: 30.4 g (759.3 mmol) of sodium hydroxide and 50 mL of water were added to a 500 mL four-necked flask and stirred at room temperature until completely dissolved, then cooled to 5 °C. A solution was prepared by dissolving 50 g (370.4 mmol) of 2,2,2-trifluoroethylamine hydrochloride in 60 mL of water and added slowly and dropwise to the above sodium hydroxide solution at 5 °C. 85 mL of tert-butyl methyl ether was added and stirred continuously for 30 minutes. Subsequently, a solution of 43.9 g (388.9 mmol) of chloroacetyl chloride dissolved in 15 mL of tert-butyl methyl ether was added slowly dropwise while maintaining 5°C. The reaction mixture was heated to 10 °C and stirring was continued for 1 hour. After confirming complete consumption of 2,2,2-trifluoroethylamine by gas chromatography, the reaction mixture was warmed up to room temperature and partitioned. The aqueous layer was extracted with 100 mL of tert-butyl methyl ether, all organic layers were combined, and the solvent was concentrated by distillation under reduced pressure to give a tert-butyl methyl ether solution of 2-chloro-N-(2,2,2-trifluoroethyl)acetamide. The product was analyzed by high performance liquid chromatography with internal standard method to give 65 g of product in 100% yield and a solution concentration of 25.1% by weight. The solution was added dropwise to heptane to induce crystallization, and the melting point of the resulting 2-chloro-N-(2,2,2-trifluoroethyl)acetamide was 53.8 °C (as determined by DSC).

References

[1] Patent: JP5652628, 2015, B2. Location in patent: Paragraph 0057
[2] Inorganic Chemistry, 2018, vol. 57, # 17, p. 11252 - 11263
[3] Chemical Communications, 2016, vol. 52, # 96, p. 13885 - 13888

2-chloro-N-(2,2,2-trifluoroethyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-chloro-N-(2,2,2-trifluoroethyl)acetamide Suppliers

Canada 1 China 48 France 1 Germany 1 India 2 Ukraine 2 United States 6 Global 61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD
Tel
571-89189769 15168342188
Fax
0571-86205065
Country
China
ProdList
229
Advantage
62
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Run-Biotech Co., Ltd.
Tel
021-57171705 13817537615
Fax
QQ3095748324
Email
sales@run-biotech.com
Country
China
ProdList
2337
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Shanghai WangFa Chemical Technology Co., Ltd.
Tel
13918479294
Fax
-
Email
xiebenfa@163.com
Country
China
ProdList
4087
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Shanghai Lanle Bird Industrial Co., Ltd.
Tel
15021845385
Email
765325601@qq.com
Country
China
ProdList
3609
Advantage
58
shandong tianhe pharmaceutical co. LTD
Tel
18954152635
Fax
qq:1982629031
Email
1982629031@qq.com
Country
China
ProdList
72
Advantage
58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19689
Advantage
58
Changzhou Yinghao Technology Development Co., Ltd
Tel
15151934985
Email
sales@yingsapharm.com
Country
China
ProdList
5181
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Shanghai Xiushi Biomedical Co., LTD
Tel
15002184385 15021598081 15002184385
Email
product001@xiushipharm.com
Country
China
ProdList
4719
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 17392282731
Fax
029-88380327
Email
1073@dideu.com
Country
China
ProdList
9992
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Aobolihui
Tel
0917-18691729 18691729963
Email
2553382659@qq.com
Country
China
ProdList
4739
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054;
Email
trendseenbio@gmail.com
Country
China
ProdList
9069
Advantage
58
Beijing FYF Chemicals Co., Ltd
Tel
010-57903446 15869909019
Email
168931144@qq.com
Country
China
ProdList
4965
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
Changzhou Qianai Biotechnology Co., Ltd
Tel
051915240519135 13961152745
Email
yudiguimo@126.COM
Country
China
ProdList
10000
Advantage
58
BEIJINGYIWANJINGRUI
Tel
15866847540
Email
dengyt2000@163.com
Country
China
ProdList
4100
Advantage
58
Shandong Libixi Biopharmaceutical Technology Co., Ltd.
Tel
15318973357; 15318973357
Email
1460285141@qq.com
Country
China
ProdList
8064
Advantage
58
Hunan Hui Bai Yi New Materials Co., Ltd
Tel
0745-2866551 19976851779
Email
3002713163@qq.com
Country
China
ProdList
7333
Advantage
58
Suzhou ARTK Medchem Co., Ltd.
Tel
+86-512-68323658 +86-18168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
39002
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49941
Advantage
58
PT CHEM GROUP LIMITED
Tel
+86-85511178;
Email
peter68@ptchemgroup.com
Country
China
ProdList
35425
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Shaoxing Chunma Chemical Co., Ltd.
Tel
--
Fax
--
Email
754300648@qq.com
Country
CHINA
ProdList
164
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shijiazhuang Simer Technology Co., Ltd.
Tel
--
Fax
--
Email
542698281@qq.com
Country
CHINA
ProdList
6695
Advantage
58
Shanghai Machine Pure Industrial Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6800
Advantage
58
More
Less

View Lastest Price from 2-chloro-N-(2,2,2-trifluoroethyl)acetamide manufacturers

Career Henan Chemical Co
Product
2-chloro-N-(2,2,2-trifluoroethyl)acetamide 170655-44-4
Price
US $1.00/KG
Min. Order
1g
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09
Career Henan Chemical Co
Product
2-chloro-N-(2,2,2-trifluoroethyl)acetamide 170655-44-4
Price
US $1.00/KG
Min. Order
1g
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09

170655-44-4, 2-chloro-N-(2,2,2-trifluoroethyl)acetamideRelated Search:

2,2,2-TRIFLUOROETHYL TRICHLOROMETHANESULFONATE

  • 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
  • AcetaMide, 2-chloro-N-(2,2,2-trifluoroethyl)-
  • 2-CgHLORO-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE
  • 170655-44-4
  • C4H5ClF3NO