Description References
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D-Mannose

Description References
Product Name
D-Mannose
CAS No.
3458-28-4
Chemical Name
D-Mannose
Synonyms
Aldohexos;D-MANNOPYRANOSE;D-MANOSE;D-MAN;CARUBINOSE;D-MannMtol;α-D-mannose;d-[1,2,3-13C3]Mannose;DL-allo-2,3,4,5,6-Pentahydroxy-hexanal;SEMINOSE
CBNumber
CB1175305
Molecular Formula
C6H12O6
Formula Weight
180.16
MOL File
3458-28-4.mol
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D-Mannose Property

Melting point:
133-140 °C(lit.)
alpha 
14 º (589nm, c=10, H2O)
Boiling point:
232.96°C (rough estimate)
Density 
1,539 g/cm3
refractive index 
1.5730 (estimate)
storage temp. 
room temp
solubility 
H2O: 50 mg/mL
form 
powder
pka
12.08(at 25℃)
color 
White
optical activity
[α]20/D +13.8±0.5°, 24 hr, c = 10% in H2O
Water Solubility 
2480 g/L (17 ºC)
λmax
λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Sensitive 
Hygroscopic
Merck 
14,5747
BRN 
1564373
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
WQZGKKKJIJFFOK-ATJJXCEKSA-N
LogP
-2.71 at 25℃
CAS DataBase Reference
3458-28-4(CAS DataBase Reference)
NIST Chemistry Reference
D-Mannose(3458-28-4)
EPA Substance Registry System
D-Mannose (3458-28-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
3
TSCA 
Yes
HS Code 
29400010
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
63580
Product name
D-(+)-Mannose
Purity
for microbiology, ≥99%
Packaging
25g
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
63579
Product name
D-(+)-Mannose
Purity
BioUltra, ≥99.5% (sum of enantiomers, HPLC)
Packaging
10g
Price
$181
Updated
2024/03/01
TCI Chemical
Product number
M0045
Product name
D-(+)-Mannose
Packaging
25G
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
M0045
Product name
D-(+)-Mannose
Packaging
100G
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
A10842
Product name
D-(+)-Mannose, 99%
Packaging
25g
Price
$47
Updated
2024/03/01
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D-Mannose Chemical Properties,Usage,Production

Description

D-Mannose is a nutritional supplement that can be found in cranberries, peaches, apples, other berries, and some plants. D-mannose is a sugar that has an important role in human metabolism, especially in the glycosylation of certain proteins. D-mannose functionalizes by the inhibition of bacterial adherence to uroepithelial cells.
More than 90 percent of recurrent urinary tract infections (UTIs) are caused by Escherichia coli (E. coli), which is normally found in the intestinal tract. The cell walls of each E. coli are covered with tiny fingerlike projections called fimbria. Mannose can bind to the lectin on the bacteria’s fimbria so that the bacteria can be effectively rinsed out by urination.
D-Mannose is by far the most effective supplement for both treatment and prevention of UTIs. And it is used for the treating carbohydrate-deficient glycoprotein syndrome, an inherited metabolic disorder.

References

[1] http://www.webmd.com
[2] Bojana Kranjcˇec, Dino Papesˇ , Silvio Altarac (2013) D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial, World J Urol, 32, 79-84

Chemical Properties

White crystalline powder

Uses

It has been used in a study to assess the synthesis of a family of amphiphilic glycopolymers. It has also been used in a study to investigate the early detection of bronchiolitis obliterans after lung transplantation.

Uses

D-mannose acts as an alternative energy source utilized by brain. It is used in the study of assessing the synthesis of amphiphilic glycopolymers and investigating early detection of bronchiolitis obliterans.It may be useful in the treatment of urinary tract infections (UTIs) and carbohydrate-deficient glycoprotein syndrome type 1b. It is also useful in the formation of glycan structure and glycosylation.

Uses

D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in inf ant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule.

Application

D-mannose is a simple sugar structurally related to glucose. It is absorbed slowly from the gastrointestinal tract, and then a large proportion of it is excreted into the urine.
D-(+)-Mannose has been used:
as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersa
as a medium component for the selection of P898012 sorgum seeds transfected with Agrobacterium
in segmented filamentous bacterium (SFB) medium supplement for culturing human cell lines
Mannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration. Majority of mannose is synthesised from its epimer glucose. It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.

Definition

ChEBI: D-Mannopyranose having alpha-configuration at the anomeric centre.

General Description

Mannose is a monosaccharide.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Mannose, a six-carbon carbohydrate, is the C-2 epimer of glucose and a critical sugar for protein glycosylation. Mannose can also be utilized by the brain as an alternative energy source.

Side effects

D-mannose appears to be generally well tolerated in people. You should be cautious about using D-mannose if you are pregnant or breastfeeding, because there has not been enough study on its safety in these circumstances. Side effects of D-mannose may include: bloating and loose stools. D-mannose supplements should be used with caution if you have diabetes. It may make it harder to control your blood sugar. High doses of D-mannose may cause kidney damage.

Source

D-mannose is a sugar that can be found in some fruits and vegetables, such as oranges, apples, peaches, broccoli and green beans. It has been used in the past to treat UTIs in animals. Now, there is some interest into whether it could also treat and prevent UTI in humans.
D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It’s metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won’t interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.

Purification Methods

Crystallise -D(+)-mannose repeatedly from EtOH, aqueous 80% EtOH, AcOH or MeOH/propan-2-ol and then dry it in vacuo over P2O5 at 60o. [For 1H NMR and equilibr

D-Mannose Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Mannose Suppliers

Nantong Tianxiang Bioengineering Co., Ltd
Tel
0513-5666452 4006716686
Fax
0513-5666452
Email
475035221@qq.com
Country
China
ProdList
1073
Advantage
58
Anhui Hegeng Biotechnology Co., Ltd.
Tel
21-65953622 13916053686
Email
sales@hegengbt.com
Country
China
ProdList
12
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2866
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-010-010-62971590 18548936886
Fax
010-62340519
Email
jack@oka-vip.com
Country
China
ProdList
6897
Advantage
58
Wuxi Jingyao Bio-Technology Co., Ltd.
Tel
0510-88770633 13961738808
Email
jingyaobiotech@126.com
Country
China
ProdList
324
Advantage
55
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3381
Advantage
56
inhua City Baikang Biological Engineering Co., LTD
Tel
0573-15557365800 15557365800
Email
78117547@qq.com
Country
China
ProdList
472
Advantage
58
Jiaxing Xinbelai Biotechnology Co., LTD
Tel
18167156872
Email
guopeng@synbiolab.cn
Country
China
ProdList
70
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
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View Lastest Price from D-Mannose manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
D-Mannose 3458-28-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Mannose 3458-28-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-07-15
Hengshui Haoye Co.,Ltd.
Product
D-Mannose 3458-28-4
Price
US $0.00/Kg/Bag
Min. Order
500Kg/Bag
Purity
99%
Supply Ability
10 tons
Release date
2021-07-15

3458-28-4, D-MannoseRelated Search:


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