Mannose Triflate

Product Name: Mannose Triflate
CAS No.: 92051-23-5
Chemical Name: Mannose Triflate
Synonyms: MANNOSE TRIFLATE;TATM;TATM USP/EP/BP;MANNOSE TRIFLATE F;beta-D-Mannopyranose;Mannose Triflate?New;Mannose triflate≥ 99%(GC);1,3,4,6-Tetra-O-acetyl-2-O-;Mannose Triflate, ultra pure;Mannose Triflate, CAS 92051-23-5
CBNumber: CB7774955
Molecular Formula: C15H19F3O12S
Formula Weight: 480.36
MOL File: 92051-23-5.mol

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Mannose Triflate Property

Melting point:: 118-122 °C
alpha: [α]D20 -14～-17゜(c=1,CHCl3)
Boiling point:: 481.6±45.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
refractive index: -16 ° (C=1, CHCl3)
storage temp.: -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
optical activity: [α]22/D -16°, c = 1 in chloroform
BRN: 4341413
InChI: InChI=1/C15H19F3O12S/c1-6(19)25-5-10-11(26-7(2)20)12(27-8(3)21)13(14(29-10)28-9(4)22)30-31(23,24)15(16,17)18/h10-14H,5H2,1-4H3/t10-,11-,12+,13+,14-/s3
InChIKey: OIBDVHSTOUGZTJ-UBBZJQTNNA-N
SMILES: [C@H]1(OC(=O)C)[C@H](OC(=O)C)[C@H](O[C@@H](OC(=O)C)[C@H]1OS(=O)(=O)C(F)(F)F)COC(=O)C |&1:0,5,10,12,17,r|

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
F: 10-21
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M1568
Product name: Mannose triflate
Purity: For PET imaging, ≥98% (TLC)
Packaging: 20mg
Price: $28.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001087
Product name: Tetra-<I>O</I>-acetyl-mannose triflate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 2each
Price: $153
Updated: 2025/07/31

Sigma-Aldrich

Product number: 655112
Product name: β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate
Purity: 98%
Packaging: 100mg
Price: $36.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001087
Product name: Tetra-O-acetyl-mannose triflate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 2EA
Price: $144
Updated: 2023/06/20

TCI Chemical

Product number: T2307
Product name: 1,3,4,6-Tetra-O-acetyl-2-O-(trifluoromethanesulfonyl)-beta-D-mannopyranose
Purity: >98.0%(GC)
Packaging: 100mg
Price: $39
Updated: 2025/07/31

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Mannose Triflate Chemical Properties,Usage,Production

Description

Mannose triflate is a glucose analog. Mannose triflate is a well-known precursor for 18F-FDG synthesis for PET applications. 18F-FDG is an imaging technique for cancer.

Physical properties

White to off-white powder or crystal

Chemical Properties

Colourless or nearly colourless crystals, mp 119 - 122℃; soluble in acetonitrile, DMSO, methanol, acetone, insoluble in aqueous media

Uses

1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose is a radiolabelled pharmaceutical preparation for diagnostic aims used in positron emission tomography.

Preparation

The tetraacetyl mannose (1.8 g, 5 mmol) was dissolved in anhydrous CH2Cl2(14 mL) containing dry pyridine (0.9 mL, 11 mmol). This solution was cooled to -15°C, and trifluoromethanesulfonic anhydride (triflic anhydride) (0.9 mL, 5.2 mmol) was added dropwise over 25 min under a nitrogen atmosphere with vigorous stirring. The mixture was then allowed to reach room temperature overnight. The reaction mixture was successively washed with ice-cold saturated aqueous NaHCO3(50 mL) and water (50 mL). The organic layer was dried over anhydrous Na2SO4, filtered, and concentrated on a rotary evaporator.2-Tf-O-AcManwas isolated by column chromatography on silica with hexane :EtOAc=1: 1 as the eluant as white solid Mannose triflate(1.4 g, 56percent).

Synthesis

358-23-6

18968-05-3

92051-23-5

General procedure for the synthesis of mannose trifluorosulfonate from trifluoromethanesulfonic anhydride and (2S,3S,4R,5R,6R)-6-(acetyloxymethyl)-3-hydroxytetrahydro-2H-pyran-2,4,5-triyltriacetate: tetraacetylmannose (5, 1.8 g, 5 mmol) was dissolved in anhydrous pyridine (0.9 mL, 11 mmol) containing anhydrous dichloromethane (14 mL). The solution was cooled to -15°C and trifluoromethanesulfonic anhydride (0.9 mL, 5.2 mmol) was added slowly and dropwise over 25 min under vigorous stirring and nitrogen protection. Subsequently, the reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction mixture was washed sequentially with ice-cold saturated aqueous sodium bicarbonate solution (50 mL) and deionized water (50 mL). The organic layer was dried with anhydrous sodium sulfate, filtered, and concentrated on a rotary evaporator. The product was purified by silica gel column chromatography using hexane:ethyl acetate (1:1, v/v) as eluent to afford mannose trifluorosulfonate (1.4 g, 56% yield) in white solid form. Thin layer chromatography (TLC) showed an Rf value of 0.5 (unfolding agent: hexane: ethyl acetate = 1:1).

References

[1] Tetrahedron, 1992, vol. 48, # 47, p. 10249 - 10264
[2] Journal of the American Chemical Society, 2010, vol. 132, # 21, p. 7405 - 7417
[3] Carbohydrate Research, 1991, vol. 210, p. 333 - 337
[4] Organic and Biomolecular Chemistry, 2009, vol. 7, # 3, p. 564 - 575
[5] Carbohydrate Research, 1984, vol. 128, p. 291 - 296

Mannose Triflate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mannose Triflate Suppliers

Belgium 1 Canada 2 China 183 Denmark 1 France 1 Germany 6 India 5 Israel 1 Japan 3 Russia 2 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 32 Global 250

Jinan Samuel Pharmaceutical Co., Ltd.

Tel: 0531-88821801 15192360884
Fax: 0531-88821802
Email: 605818151@qq.com
Country: China
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Shandong Chenxi Pharmaceutical Co., Ltd.

Tel: +86-0531-88803416 13153166250
Fax: 0531-88803416
Email: sales@chemedpharma.com
Country: China
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Shanghai Boyle Chemical Co., Ltd.

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Email: sales@boylechem.com
Country: China
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
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TCI (Shanghai) Development Co., Ltd.

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Email: Sales-CN@TCIchemicals.com
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Ark Pharm, Inc.

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Country: United States
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Energy Chemical

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Suzhou Highfine Biotech Co., Ltd

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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
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View Lastest Price from Mannose Triflate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Mannose Triflate 92051-23-5
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-17

Chongqing Soarwin Technology Co., Ltd

Product: Mannose Triflate 92051-23-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-11

Zibo Hangyu Biotechnology Development Co., Ltd

Product: TATM 92051-23-5
Price: US $50.00-500.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-31

92051-23-5, Mannose TriflateRelated Search:

Ethyl trifluoromethanesulfonate N-DECYL-BETA-D-GLUCOPYRANOSIDE glucosylglycerol Glabridin D-LYXOSE Methyl trifluoromethanesulfonate 2-[(Acetyloxy)methoxy]ethyl acetate Diacetin 1,3-BUTANEDIOL DIACETATE 2-Butoxyethyl acetate 1,6-Diacetoxyhexane L(+)-Rhamnose monohydrate 1,1,3-TRIMETHOXYBUTANE ISOPROPYL METHANESULFONATE TATM Trifluoromethane FLUOROSULFONIC ACID D-Mannose

MANNOSE TRIFLATE

MANNOSE TRIFLATE F

1,3,4,6-Tetraacetate 2-(trifluoromethanesulfonate) -D-Mannopyranose

tetraacetyltrifluoromethanesulfonyl-beta-D-mannopyranose

Mannose triflate, TATM, 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose

1-O,3-O,4-O,6-O-Tetraacetyl-2-O-(trifluoromethylsulfonyl)-β-D-mannopyranose

1-O,3-O,4-O,6-O-Tetraacetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose

β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate Mannose triflate

1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethylsulfonyl-β-D-mannopyranose

β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate,1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose, Mannose triflate, TATM

β-D-Maopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate

1,3,4,6-Tetraacetate 2-(trifluoroMethanesulfonate)

1,3,4,6-Tetra-O-acetyl-2-O-trifluoroMethane

1,3,4,6-Tetra-O-acetyl-2-O-[(trifluoromethyl)sulphonyl]-beta-D-mannopyranose

TATM, 1,3,4,6-Tetra-O-acetyl-2-O-triflyl-beta-D-mannopyranose

b-D-Mannopyranose,1,3,4,6-tetraacetate 2-(trifluoroMethanesulfonate)

beta-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoroMethanesulfonate 98%

beta-D-Mannopyranose

1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-

β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate(TATM)

acetic acid [3,4,6-triacetyloxy-5-(trifluoromethylsulfonyloxy)-2-oxanyl]methyl ester

TATM,1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose

BETA-D-MANNOPYRANOSE 1,3,4,6-TETRAACETATE 2-TRIFLATE

BETA-D-MANNOPYRANOSE, 1,3,4,6-TETRAACETATE 2-(TRIFLUOROMETHANE-SULFONATE)

BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-ACETATE 2-O-TRIFLUOROMETHANESULFONATE

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUORO-METHANESULFONYL-BETA-D-MANNOPYRANOSE

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHANSULFONYL-BETA-D-MANNOPYRANOSE

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULPHONYL-B-D-MANNOPYRANOSE

TATM

β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate

1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyranose

tetra-O-acetyl-2-O-trifluoromethane-sulfonyl-beta

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUORO-*METHANESULFONY

1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-b-D-mannopyranose

1,3,4,6-Tetra-O-acetyl-2-O-

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE, TATM

1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE(MANNOSE TRIFLATE)

TETRA-O-ACETYL-2-O-TRIFLUOROMETHANE- &

BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-AC&

Mannose Triflate PLUS, ultra pure

Mannose Triflate, ultra pure packing for GE Microlab

Mannose Triflate, ultra pure packing for GE TRACERlab MXFDG

Mannose Triflate, ultra pure

1,3,4,6-Tetra-O-Acetyl-2-O-(trifluoromethanesulfonyl)-a-D-mannopyranose

Mannose triflate≥ 99%(GC)

[(2R,3R,4S,5S,6S)-3,4,6-triacetyloxy-5-(trifluoromethylsulfonyloxy)oxan-2-yl]methyl acetate

Mannose triflate C15H19F3O12S high quality Cas number：92051-23-5

Tetra-O-acetyl-mannose triflate CRS

β-D-Mannopyranose, 1,3,4,6-tetraacetate 2-(trifluoromethanesulfonate)

TATM USP/EP/BP

1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose

β-D-Mannopyranose1,3,4,6-tetra-O-acetate2-O-trifluoromethanesulfonate

1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate-β-D-Mannopyranose

(2S,3S,4S,5R,6R)-6-(Acetoxymethyl)-3-(((trifluoromethyl)sulfonyl)oxy)tetrahydro-2H-pyran-2,4,5-triyl triacetate

1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyr

Mannose Triflate?New

1,3,4,6-Tetrα-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose