MEDICA 16

Product Name: MEDICA 16
CAS No.: 87272-20-6
Chemical Name: MEDICA 16
Synonyms: MEDICA 16;MEDICA16, 10 mM in DMSO;3,3,14,14-TETRAMETHYLHEXADECANEDIOIC ACID;3,3,14,14-TETRAMETHYLHEXADECANEDIONIC ACID;Hexadecanedioic acid, 3,3,14,14-tetramethyl-;ACLY,antidiabetogenic,ATP Citrate Lyase,antidiabetic,skeletal,Inhibitor,MEDICA16,ligands,Free Fatty Acid Receptor,MEDICA-16,insulin,FFAR,endogenous,muscle,inhibit
CBNumber: CB1175406
Molecular Formula: C20H38O4
Formula Weight: 342.51
MOL File: 87272-20-6.mol

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MEDICA 16 Property

Melting point:: 154-159 °C
Boiling point:: 485.9±18.0 °C(Predicted)
Density: 0.984±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: 28 mg/mL
form: solid
pka: 4.51±0.10(Predicted)
color: white
InChI: 1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
InChIKey: HYSMCRNFENOHJH-UHFFFAOYSA-N
SMILES: CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5693
Product name: MEDICA 16
Purity: powder, ≥97% (HPLC)
Packaging: 5mg
Price: $145
Updated: 2025/07/31

Cayman Chemical

Product number: 90290
Product name: MEDICA 16
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 90290
Product name: MEDICA 16
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 90290
Product name: MEDICA 16
Purity: ≥98%
Packaging: 10mg
Price: $160
Updated: 2024/03/01

Cayman Chemical

Product number: 90290
Product name: MEDICA 16
Purity: ≥98%
Packaging: 50mg
Price: $684
Updated: 2024/03/01

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MEDICA 16 Chemical Properties,Usage,Production

Description

MEDICA 16 is a β,β''-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.

Uses

MEDICA 16 is a β,β'-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.

Uses

MEDICA 16 is a malic enzyme and mitochondrial glycerol-3-phosphate dehydrogenase inducer.

Definition

ChEBI: MEDICA 16 is an alpha,omega-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties. It has a role as an antilipemic drug, an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor, an EC 2.3.3.8 (ATP citrate synthase) inhibitor, a G-protein-coupled receptor agonist and a hypoglycemic agent.

storage

-20°C

References

[1] TAKAFUMI HARA. Novel selective ligands for free fatty acid receptors GPR120 and GPR40.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2009, 380 3: 247-255. DOI: 10.1007/s00210-009-0425-9
[2] TIMOTHY N. C. WELLS Barbara A S. Redox control of catalysis in ATP-citrate lyase from rat liver[J]. The FEBS journal, 1992, 204 1: 249-255. DOI: 10.1111/j.1432-1033.1992.tb16631.x
[3] L. L. ATKINSON. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.[J]. Diabetes, 2002, 51 5 1: 1548-1555. DOI: 10.2337/diabetes.51.5.1548
[4] J C RUSSELL. Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16.[J]. Diabetes, 1998, 47 5: 770-778. DOI: 10.2337/diabetes.47.5.770

MEDICA 16 Preparation Products And Raw materials

Raw materials

Preparation Products

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MEDICA 16 Suppliers

China 58 Switzerland 2 United Kingdom 4 United States 10 USA 1 Global 75

J & K SCIENTIFIC LTD.

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87272-20-6, MEDICA 16Related Search:

MEDICA 16 HEXADECANEDIOIC ACID

MEDICA 16

3,3,14,14-TETRAMETHYLHEXADECANEDIOIC ACID

3,3,14,14-TETRAMETHYLHEXADECANEDIONIC ACID

Hexadecanedioic acid, 3,3,14,14-tetramethyl-

ACLY,antidiabetogenic,ATP Citrate Lyase,antidiabetic,skeletal,Inhibitor,MEDICA16,ligands,Free Fatty Acid Receptor,MEDICA-16,insulin,FFAR,endogenous,muscle,inhibit

MEDICA16, 10 mM in DMSO

87272-20-6

Biochemicals and Reagents

BioChemical

A to C

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Citrate Lyase