PAROXETINE-D4 HCL
- Product Name
- PAROXETINE-D4 HCL
- CAS No.
- 110429-35-1
- Chemical Name
- PAROXETINE-D4 HCL
- Synonyms
- PAROXETINE HCL HEMIHYDRATE;PAROXETINE HYDROCHLORIDE HEMIHYDRATE;paroxetine hydrochloride hydrate;Paroxetine-D4 hydrochloride;Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride, hydrate (2:1), (3S-trans)-;PAROXETINE-D4 HCL;BRL29060A hemihydrate;PAROXETINE-D4 HCL USP/EP/BP;PAROXETINE HYDROCHLORIDE 1/2H2O;Paroxetine hydrochloride 98~102%
- CBNumber
- CB1178023
- Molecular Formula
- C19H23ClFNO4
- Formula Weight
- 383.84
- MOL File
- 110429-35-1.mol
PAROXETINE-D4 HCL Property
- Melting point:
- 121-131 C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride.
- form
- powder
- color
- white
- λmax
- 292nm(H2O)(lit.)
- Merck
- 14,7043
- InChI
- InChI=1/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/s3
- InChIKey
- QRQSGFFISBKLMZ-BGBHMREKNA-N
- SMILES
- C([C@@H]1CNCC[C@H]1C1C=CC(F)=CC=1)OC1C=CC2OCOC=2C=1.Cl.O |&1:1,6,r|
- CAS DataBase Reference
- 110429-35-1
Safety
- Hazard Codes
- F,C,Xn
- Risk Statements
- 11-34-36/37/38-22
- Safety Statements
- 16-26-36/37/39-45-36
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- RTECS
- TM4569320
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0000630
- Product name
- Paroxetine for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 20 μg
- Price
- $156
- Updated
- 2025/07/31
- Product number
- Y0000281
- Product name
- Paroxetine hydrochloride hemihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 200 mg
- Price
- $153
- Updated
- 2025/07/31
- Product number
- P9623
- Product name
- Paroxetine hydrochloride hemihydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $171.95
- Updated
- 2025/07/31
- Product number
- BP746
- Product name
- Paroxetine impurity standard
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 25MG
- Price
- $234
- Updated
- 2025/07/31
- Product number
- BP1024
- Product name
- Paroxetine hydrochloride hemihydrate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 200MG
- Price
- $249
- Updated
- 2025/07/31
PAROXETINE-D4 HCL Chemical Properties,Usage,Production
Chemical Properties
White or almost white, crystalline powder.
Uses
Paroxetine Hydrochloride, is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder, and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).
Uses
Antidepressant;5-HT uptake inhibitor
Uses
Paroxetine hydrochloride hemihydrate has been used: as an antidepressant to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro; as a CYP 2D6 inhibitor to study its effects on the in vitro?production by human recombinant CYP 2D6 of the phenolic metabolites; as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biochem/physiol Actions
Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant
in vivo
Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues[1]. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation[2]. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group[5].
PAROXETINE-D4 HCL Preparation Products And Raw materials
Raw materials
Preparation Products
PAROXETINE-D4 HCL Suppliers
- Tel
- --
- Fax
- --
- sales@labochem.gr
- Country
- Greece
- ProdList
- 146
- Advantage
- 58
View Lastest Price from PAROXETINE-D4 HCL manufacturers
- Product
- PAROXETINE-D4 HCL 110429-35-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-26
- Product
- Paroxetine hydrochloride hydrate 110429-35-1
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ＞98%HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-06