4-(4-FLUORO-PHENYL)-PIPERIDINE
- Product Name
- 4-(4-FLUORO-PHENYL)-PIPERIDINE
- CAS No.
- 37656-48-7
- Chemical Name
- 4-(4-FLUORO-PHENYL)-PIPERIDINE
- Synonyms
- Albb-005757;4-(4-FLUORO-PHENYL)-PIPERIDINE;Piperidine, 4-(4-fluorophenyl)-;4-(Fluoro-phenyl)-piperidine hydrochloride
- CBNumber
- CB5306004
- Molecular Formula
- C11H14FN
- Formula Weight
- 179.23
- MOL File
- 37656-48-7.mol
4-(4-FLUORO-PHENYL)-PIPERIDINE Property
- Boiling point:
- 258.6±40.0 °C(Predicted)
- Density
- 1.048±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 10.18±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C11H14FN/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-4,10,13H,5-8H2
- InChIKey
- AFYALJSDFPSAAZ-UHFFFAOYSA-N
- SMILES
- N1CCC(C2=CC=C(F)C=C2)CC1
- CAS DataBase Reference
- 37656-48-7(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F1333
- Product name
- 4-(4-Fluorophenyl)piperidine
- Purity
- min. 98.0 %
- Packaging
- 250MG
- Price
- $120
- Updated
- 2025/07/31
- Product number
- B435120
- Product name
- 4-(4-Fluorophenyl)piperidine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W5851
- Product name
- 4-(4-Fluorophenyl)piperidine
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 011727
- Product name
- 4-(4-Fluoro-phenyl)-piperidinehydrochloride
- Packaging
- 250mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- 011727
- Product name
- 4-(4-Fluoro-phenyl)-piperidinehydrochloride
- Packaging
- 1g
- Price
- $46
- Updated
- 2021/12/16
4-(4-FLUORO-PHENYL)-PIPERIDINE Chemical Properties,Usage,Production
Synthesis
163630-89-5
37656-48-7
4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine (60 g, 225 mmol) was used as a raw material and dissolved in methanol (500 mL). To this solution, palladium/carbon hydroxide (20%, 5 g) was added and the reaction was shaken under hydrogen atmosphere (50 psi) for 48 hours. Upon completion of the reaction, the mixture was filtered through a glass fiber mat and washed with methanol. The filtrate was concentrated under reduced pressure to remove the solvent. The residue was dissolved in ethyl acetate and a 1 M solution of ether hydrogen chloride (300 mL) was added. The resulting solid was collected and recrystallized from 2-propanol to give 4-(4-fluorophenyl)piperidine hydrochloride as a colorless solid (30.5 g, 63% yield). Mass spectral data: m/z (ES+) 180 (M+1). The resulting 4-(4-fluorophenyl)piperidine hydrochloride sample (1 g, 4.64 mmol) was suspended in ethyl acetate and washed with saturated aqueous sodium carbonate. The organic layer was dried with anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give the title compound 4-(4-fluorophenyl)piperidine as a colorless oil (825 mg, 99% yield). Mass spectral data: m/z (ES+) 180 (M+1).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 495 - 500
[2] Patent: US6218390, 2001, B1
[3] European Journal of Medicinal Chemistry, 2005, vol. 40, # 12, p. 1197 - 1205
[4] Patent: US2003/236250, 2003, A1. Location in patent: Page 19
4-(4-FLUORO-PHENYL)-PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-FLUORO-PHENYL)-PIPERIDINE manufacturers
- Product
- 4-(4-FLUORO-PHENYL)-PIPERIDINE 37656-48-7
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28
- Product
- 4-(4-FLUORO-PHENYL)-PIPERIDINE 37656-48-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08