Paroxetine maleate
- Product Name
- Paroxetine maleate
- CAS No.
- 64006-44-6
- Chemical Name
- Paroxetine maleate
- Synonyms
- gf74;FG-7051;BRL-29060;fg7051maleate;PAROXETINE MALEATE;,(z)-2-butenedioate;ZoxaMide Impurity 2;Paroxetine maleate salt;Paroxetine maleate solution;3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin
- CBNumber
- CB1712562
- Molecular Formula
- C23H24FNO7
- Formula Weight
- 445.44
- MOL File
- 64006-44-6.mol
Paroxetine maleate Property
- Melting point:
- 136-138°C
- alpha
- D -87° (c = 5 in ethanol)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- DMSO: ~12 mg/mL
- form
- solid
- color
- white
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-36/37/38-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36-45-36/37-16-7
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- TM4569300
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P-916
- Product name
- Paroxetine maleate solution
- Purity
- 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $38.1
- Updated
- 2024/03/01
- Product number
- P1372
- Product name
- Paroxetine maleate salt
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- P1372
- Product name
- Paroxetine maleate salt
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $637
- Updated
- 2024/03/01
- Product number
- 2141
- Product name
- Paroxetinemaleate
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 2141
- Product name
- Paroxetinemaleate
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $616
- Updated
- 2021/12/16
Paroxetine maleate Chemical Properties,Usage,Production
Uses
Paroxetine maleate is a selective serotonin uptake inhibitor.
Definition
ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2
General Description
Paroxetine, marketed under trade names such as Paxil? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis.
Biological Activity
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo .
Biochem/physiol Actions
Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
storage
Store at RT
Paroxetine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
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