N-BOC-D-CYCLOHEXYLGLYCINOL
- Product Name
- N-BOC-D-CYCLOHEXYLGLYCINOL
- CAS No.
- 188348-00-7
- Chemical Name
- N-BOC-D-CYCLOHEXYLGLYCINOL
- Synonyms
- BOC-D-CHG-OL;BOC-D-CYCLOHEXYLGLYCINOL;N-BOC-D-CYCLOHEXYLGLYCINOL;N-T-BOC-D-CYCLOHEXYLGLYCINOL;N-Boc-D-2-aMino-2-cyclohexyl-ethanol;N-BOC-D-CYCLOHEXYLGLYCINOL USP/EP/BP;(R)-2-(Boc-amino)-2-cyclohexylethanol;N-T-BUTOXYCARBONYL-D-CYCLOHEXYLGLYCINOL;-tert-Butyl (1-cyclohexyl-2-hydroxyethyl);N-Boc-
D -cyclohexylglycinol - CBNumber
- CB1179626
- Molecular Formula
- C13H25NO3
- Formula Weight
- 243.34
- MOL File
- 188348-00-7.mol
N-BOC-D-CYCLOHEXYLGLYCINOL Property
- Melting point:
- 83-87 °C(lit.)
- Boiling point:
- 371.2±25.0 °C(Predicted)
- Density
- 1.037±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 12.07±0.46(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
- optical activity
- [α]20/D +13°, c = 1% in chloroform
- CAS DataBase Reference
- 188348-00-7
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-36/37/38-50/53
- Safety Statements
- 26-60-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- HS Code
- 2906190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 637556
- Product name
- N-Boc-D-cyclohexylglycinol
- Purity
- 98%
- Packaging
- 5g
- Price
- $271
- Updated
- 2023/06/20
- Product number
- 637556
- Product name
- N-Boc-D-cyclohexylglycinol
- Purity
- 98%
- Packaging
- 1g
- Price
- $92.2
- Updated
- 2023/01/07
- Product number
- 236171
- Product name
- Boc-D-cyclohexylglycinol
- Packaging
- 1g
- Price
- $237
- Updated
- 2021/12/16
- Product number
- B646228
- Product name
- N-Boc-D-cyclohexylglycinol
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 266685
- Product name
- Boc-D-cyclohexylglycinol
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
N-BOC-D-CYCLOHEXYLGLYCINOL Chemical Properties,Usage,Production
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
70491-05-3
188348-00-7
General procedure for the synthesis of tert-butyl (R)-(1-cyclohexyl-2-hydroxyethyl)carbamate from (R)-2-((tert-butoxycarbonyl)amino)-2-cyclohexylacetic acid: N-(tert-butoxycarbonyl)cyclohexylglycine (2.0 g, 7.77 mmol) was dissolved in anhydrous THF (10 mL) and the solution was cooled to 0 °C. Borane-THF solution (1 M solution of THF, 15.5 mL, 15.5 mmol) was added slowly under stirring. After addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was carefully quenched with methanol (5 mL), followed by evaporation of the volatiles under reduced pressure. The organic layer was separated by partitioning the residue between water and ethyl acetate. The organic layer was washed sequentially with saturated aqueous sodium bicarbonate, brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target product tert-butyl-(1-cyclohexyl-2-hydroxyethyl)carbamate (1.26 g, 66.7% yield). Mass spectrum (chemical ionization) m/z 144.20 (MH+-BOC).
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 14, p. 3483 - 3486
[2] Patent: WO2005/7164, 2005, A1. Location in patent: Page 28-29
[3] Patent: WO2005/7165, 2005, A1. Location in patent: Page 36
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 865 - 868
N-BOC-D-CYCLOHEXYLGLYCINOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-BOC-D-CYCLOHEXYLGLYCINOL manufacturers
- Product
- Boc-D-Chg-OL 188348-00-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-16
- Product
- Boc-D-CHG-Ol 188348-00-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-19
- Product
- N-BOC-D-CYCLOHEXYLGLYCINOL 188348-00-7
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10tons
- Release date
- 2018-08-04