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2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE

Product Name
2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE
CAS No.
51486-03-4
Chemical Name
2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE
Synonyms
AKOS MSC-0460;2-AMino-5-Methyl-3-thiophenecarboxaMid;2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE;2-AMINO-5-METHYLTHIOPHENE-3-CARBOXAMIDE;3-Thiophenecarboxamide, 2-amino-5-methyl-;2-AMino-5-Methyl-thiophene-3-carboxylic acid aMide
CBNumber
CB1182802
Molecular Formula
C6H8N2OS
Formula Weight
156.21
MOL File
51486-03-4.mol
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2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE Property

Boiling point:
274℃
Density 
1.344
Flash point:
120℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
Appearance
Light brown to brown Solid
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Safety

RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
OTV000759
Product name
2-Amino-5-methylthiophene-3-carboxamide
Packaging
1g
Price
$259
Updated
2025/07/31
TRC
Product number
A619875
Product name
2-amino-5-methylthiophene-3-carboxamide
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
A619875
Product name
2-amino-5-methylthiophene-3-carboxamide
Packaging
50mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
4696AE
Product name
2-Amino-5-methylthiophene-3-carboxamide
Packaging
5g
Price
$320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0310382
Product name
2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE
Purity
95.00%
Packaging
5MG
Price
$500.03
Updated
2021/12/16
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2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE Chemical Properties,Usage,Production

Synthesis

138564-58-6

51486-03-4

Example 8: Synthesis of N-(3-hydroxyphenethyl)-2,6-dimethylthieno[2,3-d]pyrimidin-4-amine (final compound 22). a) Preparation of 2-amino-5-methylthiophene-3-carboxamide; according to Scheme 5 Step 1: 2-amino-5-methylthiophene-3-carbonitrile (4.00 g, 28.9 mmol) was dissolved in concentrated sulphuric acid (38.8 ml), and the reaction was stirred for 20 hours at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water (250 g) and the pH was adjusted with concentrated sodium hydroxide solution to 7. Subsequently, the mixture was extracted with ethyl acetate, the organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (Flashmart Pack: 85g / 60-40um, eluent: ethyl acetate) to afford 2-amino-5-methyl-3-thiophenecarboxamide (3.10g, 69% yield) as a brown solid.

References

[1] Patent: WO2006/30031, 2006, A1. Location in patent: Page/Page column 57

2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE Suppliers

China 29 Europe 1 Germany 1 India 1 Russia 1 Switzerland 1 United Kingdom 3 United States 7 Global 44
CHIMMED Company
Tel
--
Fax
--
Email
synthesis@chimmed.ru
Country
Russia
ProdList
5006
Advantage
81

51486-03-4, 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDERelated Search:

2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXAMIDE ETHYL 5-METHYL-4-OXO-3,4-DIHYDROTHIENO[2,3-D]-PYRIMIDINE-6-CARBOXYLATE (1)benzothieno(2,3-d)pyrimidin-4(1h)-one,2,3,5,6,7,8-hexahydro-3-methyl-2-thio 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE AKOS 94123 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE 2-(2-CHLORO-ACETYLAMINO)-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID AMIDE AKOS BBS-00007188 7-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-[(2,4-DICHLOROBENZYL)SULFANYL]-3-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE 3-CYCLOHEXYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE AKOS 90535 3-ETHYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE 7-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-METHYL-2-SULFANYL-5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE 2-methyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one BUTTPARK 25\07-05 AKOS BBS-00007201 AKOS 93050 2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE

  • 2-AMINO-5-METHYLTHIOPHENE-3-CARBOXAMIDE
  • 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE
  • AKOS MSC-0460
  • 2-AMino-5-Methyl-3-thiophenecarboxaMid
  • 3-Thiophenecarboxamide, 2-amino-5-methyl-
  • 2-AMino-5-Methyl-thiophene-3-carboxylic acid aMide
  • 51486-03-4