dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate Property

Melting point:

176 °C(Solv: acetic acid (64-19-7))

Boiling point:

358.9±25.0 °C(Predicted)

Density 

1.434±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

sol dioxane, CH2Cl2, THF, C6H6; insol H2O.

form 

crystals

pka

-3.68±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate Chemical Properties,Usage,Production

Uses

3,6-Dimethyl 1,2,4,5-Tetrazine-3,6-dicarboxylate (CAS# 2166-14-5) can be used in the synthesis of N-?substituted dibenzoazepine-?pyridazine derivatives via Diels-Alder reaction of dibenzoazepines with tetrazines for their use as potential neurologically active drugs.

Application

Dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate is a reactive heteroaromatic azadiene with inverse electron demand that undergoes Diels-Alder reactions with a variety of dienophiles and isodieniphiles; it is used to prepare substituted 1,2-diazines, 1,2,4-triazines, pyrroles, pyridines, indolines, and related fused heterocycles.

storage

Dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate is a very reactive diene which  is unstable to acid, base, H2O, or protic solvents and should be stored moisture-free and refrigerated.