6-Fluoro-7-azaindole

Product Name: 6-Fluoro-7-azaindole
CAS No.: 898746-42-4
Chemical Name: 6-Fluoro-7-azaindole
Synonyms: EOS-60627;6-FLUORO-7-AZAINDOLE;2-Fluoro-1H-pyrrolo-[2,3-B]-pyridine;1H-Pyrrolo[2,3-b]pyridine, 6-fluoro-
CBNumber: CB11872034
Molecular Formula: C7H5FN2
Formula Weight: 136.13
MOL File: 898746-42-4.mol

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6-Fluoro-7-azaindole Property

Density: 1.35
storage temp.: 2-8°C
pka: 13.28±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F593313
Product name: 6-fluoro-1H-pyrrolo[2,3-b]pyridine
Packaging: 50mg
Price: $175
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-54
Product name: 6-Fluoro-1H-pyrrolo[2,3-b]pyridine
Packaging: 250mg
Price: $190
Updated: 2021/12/16

Apolloscientific

Product number: PC201367
Product name: 6-Fluoro-1H-pyrrolo[2,3-b]pyridine
Purity: 97%
Packaging: 100mg
Price: $67
Updated: 2021/12/16

AK Scientific

Product number: W9262
Product name: 6-Fluoro-7-azaindole
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Apolloscientific

Product number: PC201367
Product name: 6-Fluoro-1H-pyrrolo[2,3-b]pyridine
Purity: 97%
Packaging: 250mg
Price: $108
Updated: 2021/12/16

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6-Fluoro-7-azaindole Chemical Properties,Usage,Production

Uses

7-Azaindole compounds are important pharmaceutical intermediates that can be used to synthesize a variety of drugs. 6-Fluoro-7-azaindole is a 7-azaindole compound that can be used as an intermediate for smoking cessation drugs.

Synthesis

1001070-28-5

898746-42-4

Compound 59 (CAS:1001070-28-5, 2.58 g, 12.4 mmol) was taken as raw material and dissolved in 50 mL of methanol and 20 mL of 2N sodium hydroxide solution. The reaction mixture was stirred at room temperature for 30 minutes. After the reaction was completed, ethyl acetate was added to the mixture for extraction. The organic layer was washed with 5% aqueous sodium bicarbonate solution and subsequently dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated to afford 6-fluoro-1H-pyrrolo[2,3-b]pyridine (6-fluoro-7-azaindole, compound 44) as a semi-solid (1.68 g, 12.3 mmol, 99% yield). The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 9.6 (broad single peak, 1H), 7.95 (broad triple peak, J=8Hz, 1H), 7.31-7.27 (multiple peaks, 1H), 6.75 (double dichotomous peaks, J=8Hz, 2Hz, 1H), 6.55-6.50 (multiple peaks, 1H). Thin-layer chromatography (TLC) analysis showed an Rf value of 0.34 using ether/petroleum ether (1/1) as the unfolding agent.Liquid chromatography-mass spectrometry (LCMS) analysis: retention time (Rt) of 1.39 min, [M+H]+=137.

References

[1] Patent: US2008/9514, 2008, A1. Location in patent: Page/Page column 23
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 188 - 193

6-Fluoro-7-azaindole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Fluoro-7-azaindole Suppliers

China 87 India 2 United Kingdom 1 United States 9 Global 99

Pure Chemistry Scientific Inc.

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Matrix Scientific

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Sinova Inc.

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898746-42-4, 6-Fluoro-7-azaindoleRelated Search:

6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE 4-METHYL-7-AZAINDOLE 1,7-DIDEAZAADENINE 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBONITRILE 4-FLUORO-7-AZAINDOLE 1H-Pyrrolo[2,3-b]pyridine, 6-fluoro-

1H-Pyrrolo[2,3-b]pyridine, 6-fluoro-

EOS-60627

2-Fluoro-1H-pyrrolo-[2,3-B]-pyridine

6-FLUORO-7-AZAINDOLE

898746-42-4

Fluorine series