5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one

Product Name: 5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one
CAS No.: 297180-15-5
Chemical Name: 5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one
Synonyms: CB16.2 aka;Lipofermata,Inhibitor,Bacterial,inhibit;5-Bromo-5’phenylspiro[1H-indole-3,2’-3H-1,3,4-thiadiazole]-2-one;5-Bromo-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one;5-bromo-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one;5-bromo-5'-phenyl-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2(1H)-one;5-bromo-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;5-bromo-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-bromo-5'-phenyl-;5-bromo-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2-one
CBNumber: CB11879134
Molecular Formula: C15H10BrN3OS
Formula Weight: 360.23
MOL File: 297180-15-5.mol

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5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Property

Density: 1.76±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 20 mg/ml).
pka: 0.44±0.20(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25869
Product name: Lipofermata
Purity: ≥98%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 25869
Product name: Lipofermata
Purity: ≥98%
Packaging: 10mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 25869
Product name: Lipofermata
Purity: ≥98%
Packaging: 25mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 25869
Product name: Lipofermata
Purity: ≥98%
Packaging: 50mg
Price: $236
Updated: 2024/03/01

Apolloscientific

Product number: BISN0084
Product name: Lipofermata
Purity: 99%
Packaging: 1mg
Price: $131
Updated: 2021/12/16

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5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Chemical Properties,Usage,Production

Description

Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50?= 4.84 μM).1?It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2?Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3

Uses

Lipofermata is a fatty acid transport proteins (FATPs) inhibitor.

References

1) Sandoval?et al.?(2010),?Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol.?79?990 2) Ahowesso?et al.?(2015),?Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol.?98?167 3) Zhang?et al.?(2018),?Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov.?8?1006 br />

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Suppliers

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297180-15-5, 5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-oneRelated Search:

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5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one

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CB16.2 aka

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5-Bromo-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one

5-bromo-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2-one

5-bromo-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one

297180-15-5