8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Product Name: 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
CAS No.: 510774-50-2
Chemical Name: 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
Synonyms: 8-CPT-2'-O-ME CAMP NA;CAMP, 8-CPT-2'-O-ME, NA;-O-methyladenosine3’8CPT-2ME-CAMP, SODIUM SALT;-cyclicMonophosphateSodiumSalt;8-(4-Chlorophenylthio)-2’8-PCPT-2''-O-ME-CAMP SODIUM SALT;8-[(4-Chlorophenyl)thio]-2'-O-methyladenosine cyclic 3',5'-(hydrogen phosphate);8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT;8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
CBNumber: CB1194975
Molecular Formula: C17H17ClN5O6PS
Formula Weight: 485.84
MOL File: Mol file

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8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Property

Boiling point:: 748.9±70.0 °C(Predicted)
Density: 1.95±0.1 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
form: White to off-white crystalline powder.
pka: 0.92±0.60(Predicted)
Water Solubility: water: 10mg/mL

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1645
Product name: 8-CPT-2Me-cAMP,sodiumsalt
Purity: ≥99%(HPLC)
Packaging: 1
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC10431
Product name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging: 2mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC10431
Product name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging: 5mg
Price: $525
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC10431
Product name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging: 10mg
Price: $945
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC10431
Product name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging: 25mg
Price: $1969
Updated: 2021/12/16

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8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Chemical Properties,Usage,Production

Uses

8-(4-Chlorophenylthio)-2''-O-methyladenosine 3'',5''-cyclic Monophosphate sodium salt is an activator of the Epac cAMP receptor. It can be used in biological study of interaction between TCL1 and Epac1 in activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages

Biological Activity

Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC 50 = 2.2 mM), but not PKA (EC 50 > 10 mM). Stimulates Epac-mediated Ca 2+ -mediated Ca 2+ release in pancreatic b-cells in vitro .

in vivo

8-CPT-2'-O-Me-cAMP (2.05μM; 1 μL; intravitreal injection) inhibits development of choroidal neovascular lesions in a laser-injury model^[1].

Animal Model:	Wild type (WT) C57/Bl6 mice (choroidal neovascularization (CNV) model) ^[1]
Dosage:	2.05μM; 1 μL
Administration:	Intravitreal injection
Result:	Induced a slight increase in F-actin localization to the cell periphery, and reorganized cell junctions to a more linear shape, dose-dependent decreased in CNV volume, increased Rap1 activity in isolated RPE/choroids.

8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Suppliers

China 21 Switzerland 2 United Kingdom 2 United States 2 Global 27

3B Pharmachem (Wuhan) International Co.,Ltd.

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NewCan Biotech Limited

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Energy Chemical

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TargetMol Chemicals Inc.

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Merck KGaA

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Biosynth Biological Technology (Suzhou) Co Ltd

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Santa Cruz Biotechnology Inc

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510774-50-2, 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALTRelated Search:

Adenosine 3',5'-cyclic monophosphate sodium salt 2'-O-Methyladenosine

ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-(4-CHLOROPHENYLTHIO)-2'-O-METHYL-, SODIUM SALT

8-PCPT-2''-O-ME-CAMP SODIUM SALT

8CPT-2ME-CAMP, SODIUM SALT

8-CPT-2'-O-ME CAMP NA

8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

CAMP, 8-CPT-2'-O-ME, NA

8-[(4-Chlorophenyl)thio]-2'-O-methyladenosine cyclic 3',5'-(hydrogen phosphate)

Adenosine, 8-[(4-chlorophenyl)thio]-2'-O-methyl-, cyclic 3',5'-(hydrogen phosphate)

8-(4-Chlorophenylthio)-2&rsquo

-cyclicMonophosphateSodiumSalt

-O-methyladenosine3&rsquo

8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt

510774-50-2

C17H16ClN5O6PSNa

C17H17ClN5O6PS