MYCALOLIDE B

Product Name: MYCALOLIDE B
CAS No.: 122752-21-0
Chemical Name: MYCALOLIDE B
Synonyms: MYCALOLIDE B;Mycalolide B, Mycale sp.;MYCALOLIDE B, MYCALE SPECIES;4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C;Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen...
CBNumber: CB1196858
Molecular Formula: C52H74N4O17
Formula Weight: 1027.16
MOL File: 122752-21-0.mol

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MYCALOLIDE B Property

alpha: -53.4℃ (D) (c=1.3 CHCl3)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 20 mg/ml)
form: Clear to white solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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MYCALOLIDE B Chemical Properties,Usage,Production

Description

Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3

References

1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710 2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614 3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151

MYCALOLIDE B Preparation Products And Raw materials

Raw materials

Preparation Products

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MYCALOLIDE B Suppliers

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MYCALOLIDE B

MYCALOLIDE B, MYCALE SPECIES

Mycalolide B, Mycale sp.

4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C

Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen...

122752-21-0

C52H74N4O17