MYCALOLIDE B

Product Name: MYCALOLIDE B
CAS No.: 122752-21-0
Chemical Name: MYCALOLIDE B
Synonyms: MYCALOLIDE B;Mycalolide B, Mycale sp.;MYCALOLIDE B, MYCALE SPECIES;4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C;Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen...
CBNumber: CB1196858
Molecular Formula: C52H74N4O17
Formula Weight: 1027.16
MOL File: 122752-21-0.mol

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MYCALOLIDE B Property

alpha: -53.4℃ (D) (c=1.3 CHCl3)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 20 mg/ml)
form: Clear to white solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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MYCALOLIDE B Chemical Properties,Usage,Production

Description

Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3

References

[1] SHUICHI SAITO. Mycalolide B, a novel actin depolymerizing agent.[J]. The Journal of Biological Chemistry, 1994, 38 1: 29710-29714. DOI:10.1016/s0021-9258(18)43938-5
[2] A. SUGIDACHI. Inhibition of Rat Platelet Aggregation by Mycalolide-B, a Novel Inhibitor of Actin Polymerization with a Different Mechanism of Action from Cytochalasin-D[J]. Thrombosis and haemostasis, 1998, 79 1: 614-619. DOI:10.1055/s-0037-1614955
[3] MASATOSHI HORI . Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge[J]. FEBS Letters, 1993, 322 2: Pages 151-154. DOI:10.1016/0014-5793(93)81557-g

MYCALOLIDE B Preparation Products And Raw materials

Raw materials

Preparation Products

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MYCALOLIDE B Suppliers

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122752-21-0, MYCALOLIDE BRelated Search:

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MYCALOLIDE B

MYCALOLIDE B, MYCALE SPECIES

Mycalolide B, Mycale sp.

4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C

Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen...

122752-21-0

C52H74N4O17