MYCALOLIDE B Property

alpha 

-53.4℃ (D) (c=1.3 CHCl3)

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 20 mg/ml)

form 

Clear to white solid

color 

White

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Hazard and Precautionary Statements (GHS)

MYCALOLIDE B Chemical Properties,Usage,Production

Description

Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3

References

1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710 2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614 3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151