2',3'-DIHYDROXYACETOPHENONE
- Product Name
- 2',3'-DIHYDROXYACETOPHENONE
- CAS No.
- 13494-10-5
- Chemical Name
- 2',3'-DIHYDROXYACETOPHENONE
- Synonyms
- 1-(2,3-dihydroxyphenyl)ethan-1-one;3-Acetylcatechol;Terbutaline Impurity 28;3-Acetyl-1,2-benzenediol;2',3'-DIHYDROXYACETOPHENONE;Ethanone,1-(2,3-dihydroxyphenyl)-;Hexanoicacid,5-methyl-8-oxo-,ethylester;1-(2,3-Dihydroxyphenyl)ethanone - [D92546];Pyrazolo[1,5-a]pyridine-3-carboxylicacid,10-bromo-
- CBNumber
- CB1203248
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 13494-10-5.mol
2',3'-DIHYDROXYACETOPHENONE Property
- Melting point:
- 198-200℃
- Boiling point:
- 294.0±25.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- pka
- 8.98±0.10(Predicted)
- color
- Pale Yellow
- InChI
- InChI=1S/C8H8O3/c1-5(9)6-3-2-4-7(10)8(6)11/h2-4,10-11H,1H3
- InChIKey
- HEJLFBLJYFSKCE-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC(O)=C1O)C
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D450090
- Product name
- 2'',3''-Dihydroxyacetophenone
- Packaging
- 1g
- Price
- $755
- Updated
- 2021/12/16
- Product number
- 144515
- Product name
- 1-(2,3-Dihydroxyphenyl)ethanone
- Purity
- 95%
- Packaging
- 1g
- Price
- $903
- Updated
- 2021/12/16
- Product number
- FD22095
- Product name
- 2',3'-Dihydroxyacetophenone
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- FD22095
- Product name
- 2',3'-Dihydroxyacetophenone
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD22095
- Product name
- 2',3'-Dihydroxyacetophenone
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
2',3'-DIHYDROXYACETOPHENONE Chemical Properties,Usage,Production
Uses
2',3'-DIHYDROXYACETOPHENONE is a reagent used in the synthesis of antiproliferative agents, opioid receptor agonists, and anticoagulants.
Preparation
Also obtained by bioconversion of acetophenone through the living cells of Escherichia coli carrying plasmid pUC6256B expressing todCI-bphA2A3A4 and bphB (39.2%).
Definition
ChEBI: 2',3'-Dihydroxyacetophenone is an aromatic ketone.
Synthesis
38480-94-3
13494-10-5
The general procedure for the synthesis of 2,3-dihydroxyacetophenone from 2,3-dimethoxyacetophenone was carried out as follows: to 1M dichloromethane (68 ml) was added 1M boron tribromide solution at -70°C, followed by a solution of dichloromethane (100 ml) of 2,3-dimethoxyacetophenone (4.85 g, 26.9 mmol). The reaction mixture was cooled and stirred at room temperature for 2.5 hours. After completion of the reaction, methanol (70 ml) was added and stirring was continued for 1 hour. Subsequently, the reaction mixture was evaporated to dryness. The residue was dissolved in ethyl acetate (250 ml) and washed once with 2% NaHCO3 solution (30 ml), the organic phase was dried and the solvent was evaporated to give the crude product. The crude product was purified by methanol crystallization to give 3.10 g of the target compound as a yellow solid in 76% yield.1H NMR (300 MHz, CDCl3) δ ppm: 2.61 (s, 3H); 6.77-7.05 (t, 1H); 7.02 (dd, 1H); 7.36 (dd, 1H).
References
[1] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 183 - 192
[2] Patent: US5990142, 1999, A
[3] Chemische Berichte, 1913, vol. 46, p. 4019
[4] Chemische Berichte, 1913, vol. 46, p. 4019
[5] Journal of the American Chemical Society, 2005, vol. 127, # 29, p. 10371 - 10387
2',3'-DIHYDROXYACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2',3'-DIHYDROXYACETOPHENONE manufacturers
- Product
- 2',3'-DIHYDROXYACETOPHENONE 13494-10-5
- Price
- US $1.00/KG
- Min. Order
- 1IU
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07