ChemicalBook > CAS DataBase List > KHELLIN

KHELLIN

Product Name
KHELLIN
CAS No.
82-02-0
Chemical Name
KHELLIN
Synonyms
VISNAGIN;eskel;norkel;KHELIN;keloid;ammivin;KHELLIN;chellin;kelamin;kelicor
CBNumber
CB5269554
Molecular Formula
C14H12O5
Formula Weight
260.24
MOL File
82-02-0.mol
More
Less

KHELLIN Property

Melting point:
150154°C
Boiling point:
180200°C0.05mm Hg
Density 
1.1954 (rough estimate)
refractive index 
1.4560 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
crystalline
color 
light yellow
Water Solubility 
247.2g/L(25 ºC)
Merck 
14,5309
BRN 
263185
LogP
1.770 (est)
EPA Substance Registry System
Khellin (82-02-0)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25-38-36/37/38-23/24/25
Safety Statements 
36/37/39-45-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
LV1050000
HS Code 
2932.99.7000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89481
Product name
Khellin
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
60730
Product name
Khellin
Purity
for microscopy
Packaging
10g
Price
$234
Updated
2024/03/01
Sigma-Aldrich
Product number
00899
Product name
Khellin
Purity
analytical standard
Packaging
100MG
Price
$244
Updated
2024/03/01
TCI Chemical
Product number
K0039
Product name
Khellin
Purity
>95.0%(GC)
Packaging
5g
Price
$155
Updated
2024/03/01
TCI Chemical
Product number
K0039
Product name
Khellin
Purity
>95.0%(GC)
Packaging
25g
Price
$497
Updated
2024/03/01
More
Less

KHELLIN Chemical Properties,Usage,Production

Uses

vasodilator (coronary), photosensitizer

Uses

Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.

Definition

ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

brand name

Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002

General Description

Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.

Purification Methods

Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]

KHELLIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

KHELLIN Suppliers

Americas 1 China 84 Czech Republic 1 Egypt 1 Europe 2 France 1 Germany 4 India 5 Italy 1 Japan 1 Poland 2 Spain 1 Switzerland 3 United Kingdom 8 United States 27 USA 1 Global 143
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
More
Less

View Lastest Price from KHELLIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Khellin 82-02-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

82-02-0, KHELLINRelated Search:

Ampicillin KHELLINONE khelloside VISNAGIN,VISNAGIN(RG) KHELLIN CHEMBRDG-BB 5160161 4,9-Dimethoxy-7-(2-phenylethenyl)-5H-furo[3,2-g][1]<br>benzopyran-5-one azaspirium chloride Mecrifurone Timefurone Amikhelline KHELLIN(VISAMMIN)(PRIMARY STANDARD) 4,9-DIMETHOXY-7-(TRICHLOROMETHYL)-5H-FURO[3,2-G]CHROMEN-5-ONE 4,9-DIMETHOXY-7-PENTAFLUOROETHYL-5H-FURO-[3,2-G]-CHROMENE-5-ONE 7-DIFLUOROMETHYL-4,9-DIMETHOXY-5H-FURO-[3,2-G]-CHROMENE-5-ONE 4,9-DIMETHOXY-7-(TRIFLUOROMETHYL)-5H-FURO[3,2-G]CHROMEN-5-ONE 4,9-DIETHOXY-7-METHYL-FURO[3,2-G]CHROMEN-5-ONE 4,9-DIMETHOXY-7-(1,1,2,2-TETRAFLUOROETHYL)-5H-FURO-[3,2-G]-CHROMENE-5-ONE

  • 4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
  • 4,9-DIMETHOXY-7-METHYLFURO[3,2-G](1)BENZOPYRAN-5-ONE
  • 2-g)(1)benzopyran-5-one,4,9-dimethoxy-7-methyl-5h-furo(
  • 4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene
  • ammispasmin
  • ammivin
  • ammivisnagen
  • norkel
  • rykellin
  • simeskellina
  • vasokellina
  • viscardan
  • visnagalin
  • KHELIN
  • KHELLIN
  • 5,8-dimethoxy-2-methyl-4’,5’-furo-6,7-chromone
  • 5,8-dimethoxy-2-methyl-6,7-furanochromone
  • amicardine
  • amikellin
  • ammipuran
  • 1-nitroso-1-(phenylmethyl)urea
  • VISNAGIN
  • VISAMMIN
  • 4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one
  • KHELLIN(VISAMMIN)(P)
  • 7-Methyl-4,9-dimethoxy-5H-furo[3,2-g][1]benzopyran-5-one
  • 4,9-dimethoxy-7-methyl-furo[3,2-g]chromen-5-one
  • 4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one
  • 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one Visammin
  • KHELLIN LIGHT YELLOW CRYSTALS
  • 4,9-dimethoxy-7-methyl-5-oxofuro(3,2-g)(1)benzopyran
  • 4,9-dimethoxy-7-methyl-5-oxofuro(3,2-g)-1,2-chromene
  • 5,8-dimethoxy-2-methyl-4’,5’-furano-6,7-chromone
  • benecardin
  • cardio-khellin
  • chellin
  • chellina
  • eskel
  • gynokhellan
  • kalangin
  • kelamin
  • kelicor
  • kelicorin
  • kellosal
  • keloid
  • khelangin
  • khelfren
  • khelisem
  • khellamine
  • khellanals
  • khelloyd
  • lynamine
  • medekellin
  • methafrone
  • 4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
  • Khellin&gt
  • Khellin（Ammispasmin,Ammivin,Ammivisnagen,Benecardin,Benekardin,Cardio-khellin,Corafurone,Coronin,Eskel,Gynok...）
  • 5H-Furo[3,2-g][1]benzopyran-5-one, 4,9-dimethoxy-7-methyl-