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KHELLIN

Product Name
KHELLIN
CAS No.
82-02-0
Chemical Name
KHELLIN
Synonyms
VISNAGIN;eskel;norkel;KHELIN;keloid;ammivin;KHELLIN;chellin;kelamin;kelicor
CBNumber
CB5269554
Molecular Formula
C14H12O5
Formula Weight
260.24
MOL File
82-02-0.mol
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KHELLIN Property

Melting point:
150154°C
Boiling point:
180200°C0.05mm Hg
Density 
1.1954 (rough estimate)
refractive index 
1.4560 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
crystalline
color 
light yellow
Water Solubility 
247.2g/L(25 ºC)
Merck 
14,5309
BRN 
263185
LogP
1.770 (est)
EPA Substance Registry System
Khellin (82-02-0)
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Safety

Hazard Codes 
T
Risk Statements 
25-38-36/37/38-23/24/25
Safety Statements 
36/37/39-45-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
LV1050000
HS Code 
2932.99.7000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89481
Product name
Khellin
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
60730
Product name
Khellin
Purity
for microscopy
Packaging
10g
Price
$234
Updated
2024/03/01
Sigma-Aldrich
Product number
00899
Product name
Khellin
Purity
analytical standard
Packaging
100MG
Price
$244
Updated
2024/03/01
TCI Chemical
Product number
K0039
Product name
Khellin
Purity
>95.0%(GC)
Packaging
5g
Price
$155
Updated
2024/03/01
TCI Chemical
Product number
K0039
Product name
Khellin
Purity
>95.0%(GC)
Packaging
25g
Price
$497
Updated
2024/03/01
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KHELLIN Chemical Properties,Usage,Production

Uses

vasodilator (coronary), photosensitizer

Uses

Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.

Definition

ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

brand name

Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002

General Description

Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.

Purification Methods

Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]

KHELLIN Preparation Products And Raw materials

Raw materials

Preparation Products

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KHELLIN Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
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Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
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BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from KHELLIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Khellin 82-02-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

82-02-0, KHELLINRelated Search:


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