KHELLIN Property

Melting point:

150154°C

Boiling point:

180200°C0.05mm Hg

Density 

1.1954 (rough estimate)

refractive index 

1.4560 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

crystalline

color 

light yellow

Water Solubility 

247.2g/L(25 ºC)

Merck 

14,5309

BRN 

263185

LogP

1.770 (est)

EPA Substance Registry System

Khellin (82-02-0)

Safety

Hazard Codes 

T

Risk Statements 

25-38-36/37/38-23/24/25

Safety Statements 

36/37/39-45-26

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

LV1050000

HS Code 

2932.99.7000

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

KHELLIN Chemical Properties,Usage,Production

Uses

vasodilator (coronary), photosensitizer

Uses

Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.

Definition

ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

brand name

Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002

General Description

Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.

Purification Methods

Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]