ChemicalBook > CAS DataBase List > KHELLIN

KHELLIN

Product Name
KHELLIN
CAS No.
82-02-0
Chemical Name
KHELLIN
Synonyms
VISNAGIN;eskel;norkel;KHELIN;keloid;ammivin;KHELLIN;chellin;kelamin;kelicor
CBNumber
CB5269554
Molecular Formula
C14H12O5
Formula Weight
260.24
MOL File
82-02-0.mol
More
Less

KHELLIN Property

Melting point:
150154°C
Boiling point:
180200°C0.05mm Hg
Density 
1.1954 (rough estimate)
refractive index 
1.4560 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
crystalline
color 
light yellow
Water Solubility 
247.2g/L(25 ºC)
Merck 
14,5309
BRN 
263185
LogP
1.770 (est)
EPA Substance Registry System
Khellin (82-02-0)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25-38-36/37/38-23/24/25
Safety Statements 
36/37/39-45-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
LV1050000
HS Code 
2932.99.7000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89481
Product name
Khellin
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$316
Updated
2025/07/31
Sigma-Aldrich
Product number
60730
Product name
Khellin
Purity
for microscopy
Packaging
10g
Price
$242
Updated
2025/07/31
Sigma-Aldrich
Product number
00899
Product name
Khellin
Purity
analytical standard
Packaging
100MG
Price
$175.7
Updated
2025/07/31
TCI Chemical
Product number
K0039
Product name
Khellin
Purity
>95.0%(GC)
Packaging
5g
Price
$155
Updated
2025/07/31
TCI Chemical
Product number
K0039
Product name
Khellin
Purity
>95.0%(GC)
Packaging
25g
Price
$497
Updated
2025/07/31
More
Less

KHELLIN Chemical Properties,Usage,Production

Uses

vasodilator (coronary), photosensitizer

Uses

Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.

Definition

ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

brand name

Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002

General Description

Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.

Purification Methods

Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]

KHELLIN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

KHELLIN Suppliers

Americas 1 China 97 Czech Republic 1 Egypt 1 Europe 2 France 1 Germany 4 India 5 Italy 1 Japan 1 Poland 2 Spain 1 Switzerland 3 United Kingdom 8 United States 27 USA 1 Global 156
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5645
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
WG reagent
Tel
13391486464
Fax
QQ:14748090
Email
samwjf@163.com
Country
China
ProdList
3086
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-028-85370565-229-229 18080489829
Email
18080489829@163.com
Country
China
ProdList
8250
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Shanghai Standard Technology Co.,Ltd.
Tel
021-021-57127007-6622-6622 17621252073
Fax
+86 (21) 5132-0077
Email
luzh@nature-standard.com
Country
China
ProdList
3021
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15083
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
8025
Advantage
58
Hubei Ipure Biology Co., Ltd
Tel
+8613367258412
Fax
18062427325
Email
ada@ipurechemical.com
Country
China
ProdList
10237
Advantage
58
Wuhan ChemNorm Biotech Co.,Ltd.
Tel
+86-27-8439 4403 18971486879
Fax
+86-27-8439 4403
Email
sales@chemnorm.com
Country
CHINA
ProdList
2935
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Shanghai jingkang bioengineering co., ltd.
Tel
021-54721350 13524668266
Fax
021-5
Email
2881505714@qq.com
Country
China
ProdList
7872
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038 18502138905
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
Advantage
58
Antai Fine Chemical Technology Co.,Limited
Tel
18503026267
Email
info@antaichem.com
Country
CHINA
ProdList
9636
Advantage
58
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4195
Advantage
58
Shanghai Bohu Biotechnology Co., LTD
Tel
021-57763112 13585886131
Email
3004987436@qq.com
Country
China
ProdList
9692
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Wuhan ChemNorm co., LTD.
Tel
18971486879
Email
279414929@qq.com
Country
CHINA
ProdList
2925
Advantage
58
CHG Opto-Electronic Corporation Limited
Tel
2537653158 16621191650
Fax
QQ 2537653158
Email
2537653158@qq.com
Country
China
ProdList
7299
Advantage
58
Shanghai Hewu Biotechnology Co., LTD
Tel
021-57886085 17317861055
Email
shhebio@126.com
Country
CHINA
ProdList
7974
Advantage
58
Lingyuan Bebiansen Biological Technology Co., Ltd
Tel
18642120371
Email
2837458851@qq.com
Country
China
ProdList
7963
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Shandong Tianming Biotechnology Development Co. Ltd
Tel
400-9019001
Country
China
ProdList
15069
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
029-029-029-81148696 18161915376
Email
1040@dideu.com
Country
China
ProdList
10000
Advantage
58
More
Less

View Lastest Price from KHELLIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Khellin 82-02-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

82-02-0, KHELLINRelated Search:

Ampicillin KHELLINONE khelloside VISNAGIN,VISNAGIN(RG) KHELLIN CHEMBRDG-BB 5160161 4,9-Dimethoxy-7-(2-phenylethenyl)-5H-furo[3,2-g][1]<br>benzopyran-5-one azaspirium chloride Mecrifurone Timefurone Amikhelline KHELLIN(VISAMMIN)(PRIMARY STANDARD) 4,9-DIMETHOXY-7-(TRICHLOROMETHYL)-5H-FURO[3,2-G]CHROMEN-5-ONE 4,9-DIMETHOXY-7-PENTAFLUOROETHYL-5H-FURO-[3,2-G]-CHROMENE-5-ONE 7-DIFLUOROMETHYL-4,9-DIMETHOXY-5H-FURO-[3,2-G]-CHROMENE-5-ONE 4,9-DIMETHOXY-7-(TRIFLUOROMETHYL)-5H-FURO[3,2-G]CHROMEN-5-ONE 4,9-DIETHOXY-7-METHYL-FURO[3,2-G]CHROMEN-5-ONE 4,9-DIMETHOXY-7-(1,1,2,2-TETRAFLUOROETHYL)-5H-FURO-[3,2-G]-CHROMENE-5-ONE

  • 4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
  • 4,9-DIMETHOXY-7-METHYLFURO[3,2-G](1)BENZOPYRAN-5-ONE
  • 2-g)(1)benzopyran-5-one,4,9-dimethoxy-7-methyl-5h-furo(
  • 4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene
  • ammispasmin
  • ammivin
  • ammivisnagen
  • norkel
  • rykellin
  • simeskellina
  • vasokellina
  • viscardan
  • visnagalin
  • KHELIN
  • KHELLIN
  • 5,8-dimethoxy-2-methyl-4’,5’-furo-6,7-chromone
  • 5,8-dimethoxy-2-methyl-6,7-furanochromone
  • amicardine
  • amikellin
  • ammipuran
  • 1-nitroso-1-(phenylmethyl)urea
  • VISNAGIN
  • VISAMMIN
  • 4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one
  • KHELLIN(VISAMMIN)(P)
  • 7-Methyl-4,9-dimethoxy-5H-furo[3,2-g][1]benzopyran-5-one
  • 4,9-dimethoxy-7-methyl-furo[3,2-g]chromen-5-one
  • 4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one
  • 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one Visammin
  • KHELLIN LIGHT YELLOW CRYSTALS
  • 4,9-dimethoxy-7-methyl-5-oxofuro(3,2-g)(1)benzopyran
  • 4,9-dimethoxy-7-methyl-5-oxofuro(3,2-g)-1,2-chromene
  • 5,8-dimethoxy-2-methyl-4’,5’-furano-6,7-chromone
  • benecardin
  • cardio-khellin
  • chellin
  • chellina
  • eskel
  • gynokhellan
  • kalangin
  • kelamin
  • kelicor
  • kelicorin
  • kellosal
  • keloid
  • khelangin
  • khelfren
  • khelisem
  • khellamine
  • khellanals
  • khelloyd
  • lynamine
  • medekellin
  • methafrone
  • 4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
  • Khellin&gt
  • Khellin（Ammispasmin,Ammivin,Ammivisnagen,Benecardin,Benekardin,Cardio-khellin,Corafurone,Coronin,Eskel,Gynok...）
  • 5H-Furo[3,2-g][1]benzopyran-5-one, 4,9-dimethoxy-7-methyl-