2',3'-DIHYDROXYACETOPHENONE

Product Name: 2',3'-DIHYDROXYACETOPHENONE
CAS No.: 13494-10-5
Chemical Name: 2',3'-DIHYDROXYACETOPHENONE
Synonyms: 1-(2,3-dihydroxyphenyl)ethan-1-one;3-Acetylcatechol;Terbutaline Impurity 28;3-Acetyl-1,2-benzenediol;2',3'-DIHYDROXYACETOPHENONE;Ethanone,1-(2,3-dihydroxyphenyl)-;Hexanoicacid,5-methyl-8-oxo-,ethylester;1-(2,3-Dihydroxyphenyl)ethanone - [D92546];Pyrazolo[1,5-a]pyridine-3-carboxylicacid,10-bromo-
CBNumber: CB1203248
Molecular Formula: C8H8O3
Formula Weight: 152.15
MOL File: 13494-10-5.mol

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2',3'-DIHYDROXYACETOPHENONE Property

Melting point:: 198-200℃
Boiling point:: 294.0±25.0 °C(Predicted)
Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Solid
pka: 8.98±0.10(Predicted)
color: Pale Yellow
InChI: InChI=1S/C8H8O3/c1-5(9)6-3-2-4-7(10)8(6)11/h2-4,10-11H,1H3
InChIKey: HEJLFBLJYFSKCE-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=CC(O)=C1O)C

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D450090
Product name: 2'',3''-Dihydroxyacetophenone
Packaging: 1g
Price: $755
Updated: 2021/12/16

Matrix Scientific

Product number: 144515
Product name: 1-(2,3-Dihydroxyphenyl)ethanone
Purity: 95%
Packaging: 1g
Price: $903
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22095
Product name: 2',3'-Dihydroxyacetophenone
Packaging: 250mg
Price: $480
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22095
Product name: 2',3'-Dihydroxyacetophenone
Packaging: 10mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22095
Product name: 2',3'-Dihydroxyacetophenone
Packaging: 25mg
Price: $100
Updated: 2021/12/16

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2',3'-DIHYDROXYACETOPHENONE Chemical Properties,Usage,Production

Uses

2',3'-DIHYDROXYACETOPHENONE is a reagent used in the synthesis of antiproliferative agents, opioid receptor agonists, and anticoagulants.

Preparation

Also obtained by bioconversion of acetophenone through the living cells of Escherichia coli carrying plasmid pUC6256B expressing todCI-bphA2A3A4 and bphB (39.2%).

Definition

ChEBI: 2',3'-Dihydroxyacetophenone is an aromatic ketone.

Synthesis

38480-94-3

13494-10-5

The general procedure for the synthesis of 2,3-dihydroxyacetophenone from 2,3-dimethoxyacetophenone was carried out as follows: to 1M dichloromethane (68 ml) was added 1M boron tribromide solution at -70°C, followed by a solution of dichloromethane (100 ml) of 2,3-dimethoxyacetophenone (4.85 g, 26.9 mmol). The reaction mixture was cooled and stirred at room temperature for 2.5 hours. After completion of the reaction, methanol (70 ml) was added and stirring was continued for 1 hour. Subsequently, the reaction mixture was evaporated to dryness. The residue was dissolved in ethyl acetate (250 ml) and washed once with 2% NaHCO3 solution (30 ml), the organic phase was dried and the solvent was evaporated to give the crude product. The crude product was purified by methanol crystallization to give 3.10 g of the target compound as a yellow solid in 76% yield.1H NMR (300 MHz, CDCl3) δ ppm: 2.61 (s, 3H); 6.77-7.05 (t, 1H); 7.02 (dd, 1H); 7.36 (dd, 1H).

References

[1] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 183 - 192
[2] Patent: US5990142, 1999, A
[3] Chemische Berichte, 1913, vol. 46, p. 4019
[4] Chemische Berichte, 1913, vol. 46, p. 4019
[5] Journal of the American Chemical Society, 2005, vol. 127, # 29, p. 10371 - 10387

2',3'-DIHYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2',3'-DIHYDROXYACETOPHENONE Suppliers

Canada 1 China 77 India 1 United Kingdom 3 United States 9 Global 91

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View Lastest Price from 2',3'-DIHYDROXYACETOPHENONE manufacturers

Career Henan Chemical Co

Product: 2',3'-DIHYDROXYACETOPHENONE 13494-10-5
Price: US $1.00/KG
Min. Order: 1IU
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

13494-10-5, 2',3'-DIHYDROXYACETOPHENONERelated Search:

2',3',4'-TRIMETHOXYACETOPHENONE 7,8-Dihydroxyflavone 2,3,3',4'-TETRAMETHOXYBENZOPHENONE PURPURIN Alizarin Alizarin Red S 3,7,3',4'-TETRAMETHYLGOSSYPETIN 2,3,4-Trihydroxybenzophenone 2',3',4'-TRIHYDROXYACETOPHENONE PURPUROGALLIN EUPATORIN-5-METHYL ETHER Alizarin Complexone KHELLIN 1,2,5,8-TETRAHYDROXYANTHRAQUINONE 2',6'-Dihydroxyacetophenone DIHYDROXYACETOPHENONE,3,4-,DIHYDROXYACETOPHENONE,3',4'-DIHYDROXYACETOPHENONE,3,4-DIHYDROXYACETOPHENONE,3,4-Dihydroxyacetophenone 3',4'-Dihydroxyacetophenone 2',4'-DIHYDROXYACETOPHENONE,2',4'-Dihydroxyacetophenone 4-Acetylresorcinol 2,4-Dihydroxyacetophenone,2,4-DIHYDROXYACETOPHENONE,2,4-Dihydroxyacetophenone,99% 1-(2,4-Bis(benzoyloxy)phenyl)ethanone

2',3'-DIHYDROXYACETOPHENONE

3-Acetylcatechol

1-(2,3-dihydroxyphenyl)ethan-1-one

3-Acetyl-1,2-benzenediol

Ethanone,1-(2,3-dihydroxyphenyl)-

Terbutaline Impurity 28

Pyrazolo[1,5-a]pyridine-3-carboxylicacid,10-bromo-

Hexanoicacid,5-methyl-8-oxo-,ethylester

1-(2,3-Dihydroxyphenyl)ethanone - [D92546]

13494-10-5

Aromatics

Intermediates