ChemicalBook > CAS DataBase List > 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE

5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE

Product Name: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
CAS No.: 18672-03-2
Chemical Name: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
Synonyms: 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE;2-Amino-5,6-dichlorobenzimidazole;5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE;2-Amino-5,6-dichloro-1H-benzimidazole;1H-Benzimidazol-2-amine, 5,6-dichloro-;5,6-dichloro-1H-1,3-benzodiazol-2-amine
CBNumber: CB1206007
Molecular Formula: C7H5Cl2N3
Formula Weight: 202.04
MOL File: 18672-03-2.mol

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5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Property

Melting point:: 244-246℃
Boiling point:: 435.4±48.0 °C(Predicted)
Density: 1.665±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.47±0.10(Predicted)
Appearance: Light yellow to light brown Solid
CAS DataBase Reference: 18672-03-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0142863
Product name: 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE
Purity: 98.00%
Packaging: 1G
Price: $1068.38
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142863
Product name: 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE
Purity: 98.00%
Packaging: 5G
Price: $2512.13
Updated: 2021/12/16

Labseeker

Product number: SC-51871
Product name: 5,6-dichloro-1H-benzo[d]imidazol-2-amine
Purity: 95
Packaging: 2g
Price: $1633
Updated: 2021/12/16

Labseeker

Product number: SC-51871
Product name: 5,6-dichloro-1H-benzo[d]imidazol-2-amine
Purity: 95
Packaging: 5g
Price: $2100
Updated: 2021/12/16

Chemenu

Product number: CM250713
Product name: 5,6-Dichloro-1H-benzo[d]imidazol-2-amine
Purity: 96%
Packaging: 1g
Price: $276
Updated: 2021/12/16

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5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Chemical Properties,Usage,Production

Uses

2-Amino-5,6-dichlorobenzimidazole is used as pharmaceutical intermediate.

Synthesis

5348-42-5

506-68-3

18672-03-2

Example 138: General procedure for the synthesis of 5,6-dichloro-1H-benzo[d]imidazol-2-amine from 4,5-dichloro-1,2-benzenediamine and cyanogen bromide: Cyanogen bromide (0.063 g, 0.6 mmol) was added to a mixture of acetonitrile (10 mL) and water (0.81 g, 0.562 mmol) of 4,5-dichlorobenzene-1,2-diamine (0.81 g, 0.562 mmol) at 0 °C. (2 mL) in a mixed solution of acetonitrile (10 mL) and water (2 mL). The reaction mixture was gradually warmed to room temperature with continuous stirring for 14 hours. Subsequently, saturated aqueous sodium bicarbonate solution (50 mL) was added to the reaction mixture and shaken thoroughly. The resulting solid was collected by filtration, washed with water and dried under reduced pressure to afford 5,6-dichloro-1H-benzo[d]imidazol-2-amine 0.43 g in 50% yield. Mass spectrometry (EI) analysis showed a molecular ion peak (MH+) of 203.

References

[1] Journal of Medicinal Chemistry, 1995, vol. 38, # 20, p. 4098 - 4105
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 8, p. 1252 - 1262
[3] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 16, p. 2221 - 2224
[4] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 208
[5] Angewandte Chemie - International Edition, 2012, vol. 51, # 41, p. 10364 - 10367

5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Suppliers

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View Lastest Price from 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE 18672-03-2
Price: US $90.00-900.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-13

18672-03-2, 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINERelated Search:

Xylene BENZIMIDAVIR 5,6-DICHLOROBENZIMIDAZOLE 5,6-DICHLORO-2-ISOPROPYLAMINOBENZIMIDAZOLE METHYL 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-YLCARBAMATE 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE N-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)GUANIDINE

5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE

5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE

1H-Benzimidazol-2-amine, 5,6-dichloro-

2-Amino-5,6-dichloro-1H-benzimidazole

2-Amino-5,6-dichlorobenzimidazole

5,6-dichloro-1H-1,3-benzodiazol-2-amine

18672-03-2

C7H5Cl2N3

blocks

Imidazoles

pharmacetical